دورية أكاديمية
أعرض في EDS

Gut bacteriome and mood disorders in women with PCOS.

التفاصيل البيبلوغرافية
العنوان: Gut bacteriome and mood disorders in women with PCOS.
المؤلفون: Lee S; Department of Obstetrics and Gynecology, Research Unit of Clinical Medicine, Medical Research Center, Oulu University Hospital, University of Oulu, Oulu, Finland.; Department of Obstetrics and Gynaecology, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia., Tejesvi MV; Research Unit of Clinical Medicine, University of Oulu, Oulu, Finland.; Ecology and Genetics, University of Oulu, Oulu, Finland., Hurskainen E; Department of Obstetrics and Gynecology, Research Unit of Clinical Medicine, Medical Research Center, Oulu University Hospital, University of Oulu, Oulu, Finland., Aasmets O; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Plaza-Díaz J; Faculty of Pharmacy, Department of Biochemistry and Molecular Biology II, University of Granada, Granada, Spain.; Instituto de Investigación Biosanitaria ibs. GRANADA, Granada, Spain.; Children's Hospital of Eastern Ontario Research Institute, Ottawa, Canada., Franks S; Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK., Morin-Papunen L; Department of Obstetrics and Gynecology, Research Unit of Clinical Medicine, Medical Research Center, Oulu University Hospital, University of Oulu, Oulu, Finland., Tapanainen JS; Department of Obstetrics and Gynecology, Research Unit of Clinical Medicine, Medical Research Center, Oulu University Hospital, University of Oulu, Oulu, Finland.; Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Department of Obstetrics and Gynaecology, HFR-Cantonal Hospital of and University of Fribourg, Fribourg, Switzerland., Ruuska TS; Research Unit of Clinical Medicine, University of Oulu, Oulu, Finland.; Department of Pediatrics and Adolescent Medicine and Medical Research Center, Oulu University Hospital, Oulu, Finland., Altmäe S; Faculty of Pharmacy, Department of Biochemistry and Molecular Biology II, University of Granada, Granada, Spain.; Instituto de Investigación Biosanitaria ibs. GRANADA, Granada, Spain.; Division of Obstetrics and Gynaecology, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden., Org E; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Salumets A; Department of Obstetrics and Gynaecology, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia.; Division of Obstetrics and Gynaecology, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden.; Competence Centre on Health Technologies, Tartu, Estonia., Arffman RK; Department of Obstetrics and Gynecology, Research Unit of Clinical Medicine, Medical Research Center, Oulu University Hospital, University of Oulu, Oulu, Finland., Piltonen TT; Department of Obstetrics and Gynecology, Research Unit of Clinical Medicine, Medical Research Center, Oulu University Hospital, University of Oulu, Oulu, Finland.
المصدر: Human reproduction (Oxford, England) [Hum Reprod] 2024 Jun 03; Vol. 39 (6), pp. 1291-1302.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 8701199 Publication Model: Print Cited Medium: Internet ISSN: 1460-2350 (Electronic) Linking ISSN: 02681161 NLM ISO Abbreviation: Hum Reprod Subsets: MEDLINE
أسماء مطبوعة: Publication: Oxford, UK : Oxford University Press
Original Publication: Oxford ; Washington, DC : Published for the European Society of Human Reproduction and Embryology by IRL Press, [c1986-
مواضيع طبية MeSH: Polycystic Ovary Syndrome*/complications , Polycystic Ovary Syndrome*/microbiology , Gastrointestinal Microbiome* , Mood Disorders*/epidemiology, Humans ; Female ; Finland/epidemiology ; Middle Aged ; Adult ; Cohort Studies ; Case-Control Studies ; Feces/microbiology
مستخلص: Study Question: How does the gut bacteriome differ based on mood disorders (MDs) in women with polycystic ovary syndrome (PCOS), and how can the gut bacteriome contribute to the associations between these two conditions?
Summary Answer: Women with PCOS who also have MDs exhibited a distinct gut bacteriome with reduced alpha diversity and a significantly lower abundance of Butyricicoccus compared to women with PCOS but without MDs.
What Is Known Already: Women with PCOS have a 4- to 5-fold higher risk of having MDs compared to women without PCOS. The gut bacteriome has been suggested to influence the pathophysiology of both PCOS and MDs.
Study Design, Size, Duration: This population-based cohort study was derived from the Northern Finland Birth Cohort 1966 (NFBC1966), which includes all women born in Northern Finland in 1966. Women with PCOS who donated a stool sample at age 46 years (n = 102) and two BMI-matched controls for each case (n = 205), who also responded properly to the MD criteria scales, were included.
Participants/materials, Setting, Methods: A total of 102 women with PCOS and 205 age- and BMI-matched women without PCOS were included. Based on the validated MD criteria, the subjects were categorized into MD or no-MD groups, resulting in the following subgroups: PCOS no-MD (n = 84), PCOS MD (n = 18), control no-MD (n = 180), and control MD (n = 25). Clinical characteristics were assessed at age 31 years and age 46 years, and stool samples were collected from the women at age 46 years, followed by the gut bacteriome analysis using 16 s rRNA sequencing. Alpha diversity was assessed using observed features and Shannon's index, with a focus on genera, and beta diversity was characterized using principal components analysis (PCA) with Bray-Curtis Dissimilarity at the genus level. Associations between the gut bacteriome and PCOS-related clinical features were explored by Spearman's correlation coefficient. A P-value for multiple testing was adjusted with the Benjamini-Hochberg false discovery rate (FDR) method.
Main Results and the Role of Chance: We observed changes in the gut bacteriome associated with MDs, irrespective of whether the women also had PCOS. Similarly, PCOS MD cases showed a lower alpha diversity (Observed feature, PCOS no-MD, median 272; PCOS MD, median 208, FDR = 0.01; Shannon, PCOS no-MD, median 5.95; PCOS MD, median 5.57, FDR = 0.01) but also a lower abundance of Butyricicoccus (log-fold changeAnalysis of Compositions of Microbiomes with Bias Correction (ANCOM-BC)=-0.90, FDRANCOM-BC=0.04) compared to PCOS no-MD cases. In contrast, in the controls, the gut bacteriome did not differ based on MDs. Furthermore, in the PCOS group, Sutterella showed positive correlations with PCOS-related clinical parameters linked to obesity (BMI, r2=0.31, FDR = 0.01; waist circumference, r2=0.29, FDR = 0.02), glucose metabolism (fasting glucose, r2=0.46, FDR < 0.001; fasting insulin, r2=0.24, FDR = 0.05), and gut barrier integrity (zonulin, r2=0.25, FDR = 0.03).
Limitations, Reasons for Caution: Although this was the first study to assess the link between the gut bacteriome and MDs in PCOS and included the largest PCOS dataset for the gut microbiome analysis, the number of subjects stratified by the presence of MDs was limited when contrasted with previous studies that focused on MDs in a non-selected population.
Wider Implications of the Findings: The main finding is that gut bacteriome is associated with MDs irrespective of the PCOS status, but PCOS may also modulate further the connection between the gut bacteriome and MDs.
Study Funding/competing Interest(s): This research was funded by the European Union's Horizon 2020 Research and Innovation Programme under the Marie Sklodowska-Curie Grant Agreement (MATER, No. 813707), the Academy of Finland (project grants 315921, 321763, 336449), the Sigrid Jusélius Foundation, Novo Nordisk Foundation (NNF21OC0070372), grant numbers PID2021-12728OB-100 (Endo-Map) and CNS2022-135999 (ROSY) funded by MCIN/AEI/10.13039/501100011033 and ERFD A Way of Making Europe. The study was also supported by EU QLG1-CT-2000-01643 (EUROBLCS) (E51560), NorFA (731, 20056, 30167), USA/NIH 2000 G DF682 (50945), the Estonian Research Council (PRG1076, PRG1414), EMBO Installation (3573), and Horizon 2020 Innovation Grant (ERIN, No. EU952516). The funders did not participate in any process of the study. We have no conflicts of interest to declare.
Trial Registration Number: N/A.
(© The Author(s) 2024. Published by Oxford University Press on behalf of European Society of Human Reproduction and Embryology.)
References: J Leukoc Biol. 2021 Jun;109(6):1045-1061. (PMID: 33020981)
Nucleic Acids Res. 2013 Jan;41(Database issue):D590-6. (PMID: 23193283)
BMC Microbiol. 2017 Sep 13;17(1):194. (PMID: 28903732)
Nat Biotechnol. 2019 Aug;37(8):852-857. (PMID: 31341288)
PLoS One. 2017 Jan 3;12(1):e0168390. (PMID: 28045919)
Diabetes Res Clin Pract. 2020 Apr;162:108116. (PMID: 32194221)
J Clin Endocrinol Metab. 2021 Mar 8;106(3):858-871. (PMID: 33205157)
Nat Rev Immunol. 2010 Mar;10(3):159-69. (PMID: 20182457)
Nat Rev Immunol. 2010 Oct;10(10):735-44. (PMID: 20865020)
Arch Womens Ment Health. 2022 Apr;25(2):301-311. (PMID: 34841466)
NPJ Biofilms Microbiomes. 2021 Jul 15;7(1):60. (PMID: 34267209)
Cell Host Microbe. 2017 Nov 8;22(5):589-599. (PMID: 29120742)
Nat Rev Endocrinol. 2018 May;14(5):270-284. (PMID: 29569621)
Microbiome. 2014 May 05;2:15. (PMID: 24910773)
J Am Coll Nutr. 2020 May-Jun;39(4):371-382. (PMID: 31513473)
Front Pharmacol. 2021 May 13;12:670054. (PMID: 34054541)
J Clin Endocrinol Metab. 2023 Sep 18;108(10):2447-2469. (PMID: 37580314)
Reprod Biomed Online. 2023 Jul;47(1):129-150. (PMID: 37208218)
Toxins (Basel). 2022 Jan 11;14(1):. (PMID: 35051027)
Nat Methods. 2016 Jul;13(7):581-3. (PMID: 27214047)
Microbes Infect. 2022 Mar;24(2):104892. (PMID: 34678464)
ISME J. 2012 Aug;6(8):1621-4. (PMID: 22402401)
Front Cell Dev Biol. 2021 Mar 16;9:650664. (PMID: 33796536)
Nat Commun. 2020 Jul 14;11(1):3514. (PMID: 32665548)
J Psychiatr Res. 2018 Sep;104:130-136. (PMID: 30029052)
Trends Endocrinol Metab. 2015 Mar;26(3):136-43. (PMID: 25591984)
Commun Stat Appl Methods. 2015 Nov;22(6):665-674. (PMID: 26688802)
Sci Rep. 2018 Aug 15;8(1):12216. (PMID: 30111822)
PLoS One. 2015 Aug 07;10(8):e0134802. (PMID: 26252519)
Front Endocrinol (Lausanne). 2020 Jan 31;11:25. (PMID: 32082260)
Fertil Steril. 2018 May;109(5):888-899. (PMID: 29778388)
Postgrad Med J. 2018 Aug;94(1114):446-452. (PMID: 30026389)
Nat Biotechnol. 2017 Nov;35(11):1069-1076. (PMID: 28967887)
Clin Chem. 2013 Apr;59(4):617-28. (PMID: 23401286)
Neuropsychiatr Dis Treat. 2018 Dec 03;14:3329-3337. (PMID: 30584306)
PLoS One. 2022 May 27;17(5):e0268466. (PMID: 35622782)
J Clin Periodontol. 2004 Oct;31(10):894-902. (PMID: 15367195)
J Clin Endocrinol Metab. 2018 Apr 1;103(4):1502-1511. (PMID: 29370410)
Hum Reprod. 2017 May 1;32(5):1075-1091. (PMID: 28333286)
Hum Reprod. 2004 Jan;19(1):41-7. (PMID: 14688154)
J Microbiol Methods. 2022 May;196:106476. (PMID: 35490989)
Clin Psychol Rev. 2021 Feb;83:101943. (PMID: 33271426)
Front Cell Infect Microbiol. 2021 Jul 19;11:665406. (PMID: 34350129)
Animal Model Exp Med. 2018 Sep 25;1(3):180-188. (PMID: 30891563)
Psychiatry Res. 2013 Dec 30;210(3):1301-3. (PMID: 24135551)
Front Microbiol. 2021 Sep 28;12:711137. (PMID: 34650525)
Paediatr Perinat Epidemiol. 1988 Jan;2(1):59-88. (PMID: 2976931)
PLoS One. 2019 Sep 30;14(9):e0223274. (PMID: 31568518)
J Neurosci Res. 2019 Oct;97(10):1223-1241. (PMID: 31144383)
Nutrients. 2013 Mar 12;5(3):829-51. (PMID: 23482058)
Am J Reprod Immunol. 2022 Aug;88(2):e13580. (PMID: 35598286)
Clin Endocrinol (Oxf). 2018 Nov;89(5):628-633. (PMID: 29992612)
J Clin Endocrinol Metab. 2006 Nov;91(11):4237-45. (PMID: 16940456)
Obes Rev. 2023 Jul;24(7):e13566. (PMID: 37062534)
Microbiome. 2016 Jul 30;4(1):40. (PMID: 27473284)
J Biol Chem. 2017 May 26;292(21):8569-8576. (PMID: 28389557)
Am J Physiol Gastrointest Liver Physiol. 2006 Mar;290(3):G496-504. (PMID: 16474009)
Gut. 2007 Mar;56(3):343-50. (PMID: 16908512)
BMC Microbiol. 2012 Jul 30;12:158. (PMID: 22846661)
J Clin Endocrinol Metab. 2020 Jun 1;105(6):. (PMID: 31970418)
Sci Rep. 2023 Jan 3;13(1):114. (PMID: 36596832)
Psychol Med. 2008 Nov;38(11):1659-69. (PMID: 18485262)
Front Microbiol. 2016 Oct 26;7:1706. (PMID: 27833600)
Reprod Sci. 2022 Nov;29(11):3106-3123. (PMID: 34642910)
Front Cell Infect Microbiol. 2020 Sep 29;10:567268. (PMID: 33134190)
Endocr Connect. 2020 Jan;9(1):63-73. (PMID: 31972546)
J Microbiol. 2020 Mar;58(3):206-216. (PMID: 32108316)
Curr Opin Neurobiol. 2020 Jun;62:102-114. (PMID: 32163822)
Nutrients. 2020 Jun 01;12(6):. (PMID: 32492805)
Steroids. 2013 Aug;78(8):761-6. (PMID: 23624031)
Acta Neuropsychiatr. 2020 Feb;32(1):1-9. (PMID: 31186075)
Int J Mol Sci. 2021 Mar 08;22(5):. (PMID: 33800490)
PLoS One. 2010 Mar 10;5(3):e9490. (PMID: 20224823)
Front Microbiol. 2017 Feb 28;8:324. (PMID: 28293234)
ISME J. 2017 Jan;11(1):1-6. (PMID: 27636395)
Can J Physiol Pharmacol. 2020 Nov;98(11):803-809. (PMID: 32150694)
Am J Physiol Gastrointest Liver Physiol. 2001 Oct;281(4):G907-15. (PMID: 11557510)
Eur J Nutr. 2023 Feb;62(1):139-155. (PMID: 35918555)
Gut. 2017 Jun;66(6):1031-1038. (PMID: 27053630)
J Endocr Soc. 2020 Nov 16;5(2):bvaa177. (PMID: 33381671)
Acta Derm Venereol. 2023 Jan 04;103:adv00837. (PMID: 36598159)
Med Hypotheses. 2012 Jul;79(1):104-12. (PMID: 22543078)
Reprod Sci. 2020 Jan;27(1):290-300. (PMID: 32046436)
J Clin Endocrinol Metab. 2017 Jun 1;102(6):1861-1869. (PMID: 28323926)
Front Psychiatry. 2021 Sep 13;12:651536. (PMID: 34589003)
BMC Med. 2022 Jun 15;20(1):204. (PMID: 35701845)
Diabetologia. 1985 Jul;28(7):412-9. (PMID: 3899825)
Front Microbiol. 2022 Jul 01;13:911992. (PMID: 35847083)
J Ovarian Res. 2020 Jun 17;13(1):73. (PMID: 32552864)
mBio. 2012 Jan 10;3(1):. (PMID: 22233678)
J Microbiol Methods. 2019 Sep;164:105668. (PMID: 31302202)
mSystems. 2019 Apr 16;4(2):. (PMID: 31020040)
Fertil Steril. 2020 Jun;113(6):1286-1298.e4. (PMID: 32482258)
Hum Reprod. 2011 Jun;26(6):1399-407. (PMID: 21436137)
Nutrients. 2020 Dec 07;12(12):. (PMID: 33297486)
معلومات مُعتمدة: European Union's Horizon 2020 Research and Innovation Programme
فهرسة مساهمة: Keywords: PCOS; anxiety; depression; gut bacteriome; gut microbiome; mood disorders; polycystic ovary syndrome
تواريخ الأحداث: Date Created: 20240413 Date Completed: 20240603 Latest Revision: 20240605
رمز التحديث: 20240605
مُعرف محوري في PubMed: PMC11145006
DOI: 10.1093/humrep/deae073
PMID: 38614956
قاعدة البيانات: MEDLINE
الوصف
تدمد:1460-2350
DOI:10.1093/humrep/deae073