دورية أكاديمية
Triple-induction treatment for locally advanced non-small cell lung cancer: a case report of pathological complete response.
| العنوان: | Triple-induction treatment for locally advanced non-small cell lung cancer: a case report of pathological complete response. |
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| المؤلفون: | Werner RS; Department of Thoracic Surgery, University Hospital Zurich, Rämistrasse 100, Zurich, 8091, Switzerland.; Department of Oncology, Regional Hospital Uster, Brunnenstrasse 42, Uster, 8610, Switzerland., Lauk O; Department of Thoracic Surgery, University Hospital Zurich, Rämistrasse 100, Zurich, 8091, Switzerland.; Department of Oncology, Regional Hospital Uster, Brunnenstrasse 42, Uster, 8610, Switzerland., Tscherry G; Department of Medical Oncology and Hematology, University Hospital Zurich, Rämistrasse 100, Zurich, 8091, Switzerland., Curioni-Fontecedro A; Department of Medical Oncology and Hematology, University Hospital Zurich, Rämistrasse 100, Zurich, 8091, Switzerland.; Present address: Clinic of Oncology, Cantonal Hospital Fribourg, Fribourg, 1752, Switzerland.; Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland., Höller S; Department of Pathology, University Hospital Zurich, Rämistrasse 100, Zurich, 8091, Switzerland.; Present address: Institute of Clinical Pathology, Stadtspital Zurich, Birmensdorferstrasse 497, Zurich, 8063, Switzerland., Opitz I; Department of Thoracic Surgery, University Hospital Zurich, Rämistrasse 100, Zurich, 8091, Switzerland. Isabelle.schmitt-opitz@usz.ch.; Department of Oncology, Regional Hospital Uster, Brunnenstrasse 42, Uster, 8610, Switzerland. Isabelle.schmitt-opitz@usz.ch. |
| المصدر: | Journal of cardiothoracic surgery [J Cardiothorac Surg] 2024 Apr 15; Vol. 19 (1), pp. 207. Date of Electronic Publication: 2024 Apr 15. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 101265113 Publication Model: Electronic Cited Medium: Internet ISSN: 1749-8090 (Electronic) Linking ISSN: 17498090 NLM ISO Abbreviation: J Cardiothorac Surg Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [London] : BioMed Central, 2006- |
| مواضيع طبية MeSH: | Carcinoma, Non-Small-Cell Lung*/therapy , Lung Neoplasms*/therapy, Humans ; Middle Aged ; Neoadjuvant Therapy ; Chemoradiotherapy ; Pathologic Complete Response |
| مستخلص: | Background: In patients with resectable stage III non-small cell lung cancer (NSCLC), induction chemoimmunotherapy followed by surgical resection has shown unprecedented rates of pathological response and event-free survival. However, a triple-induction including radiochemotherapy and immunotherapy followed by surgical resection has not been routinely established in clinical practice. Case Presentation: We report the case of a 47-year-old patient with stage IIIA NSCLC who was treated in a combined concept including induction concurrent radiochemotherapy, followed by 4 cycles of pembrolizumab and subsequent intrapericardial left-sided pneumonectomy. Histological analysis revealed a pathological complete response. Conclusions: The case demonstrates that the combination of neoadjuvant chemo-, radio- and immunotherapy in advanced NSCLC may lead to a relevant down-staging and may enable a R0-resection of a borderline resectable tumor. However, the combination of four different treatment modalities requires resilience and a good performance status. A triple induction treatment may be a promising option for selected patients with locally advanced NSCLC and good performance status. (© 2024. The Author(s).) |
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| فهرسة مساهمة: | Keywords: Advanced lung cancer; Case report; Multimodality treatment; Pathological complete response; Pneumonectomy |
| تواريخ الأحداث: | Date Created: 20240414 Date Completed: 20240416 Latest Revision: 20240417 |
| رمز التحديث: | 20240417 |
| مُعرف محوري في PubMed: | PMC11017483 |
| DOI: | 10.1186/s13019-024-02759-y |
| PMID: | 38616248 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1749-8090 |
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| DOI: | 10.1186/s13019-024-02759-y |