Microglia undergo disease-associated transcriptional activation and CX3C motif chemokine receptor 1 expression regulates neurogenesis in the aged brain.

التفاصيل البيبلوغرافية
العنوان:	Microglia undergo disease-associated transcriptional activation and CX3C motif chemokine receptor 1 expression regulates neurogenesis in the aged brain.
المؤلفون:	Fritze J; Department of Experimental Medical Sciences, Faculty of Medicine, Stem Cells, Aging and Neurodegeneration Group, Lund University, Lund, Sweden.; Lund Stem Cell Center, Lund, Sweden., Muralidharan C; Department of Experimental Medical Sciences, Faculty of Medicine, Stem Cells, Aging and Neurodegeneration Group, Lund University, Lund, Sweden.; Lund Stem Cell Center, Lund, Sweden.; Department of Experimental Medical Science, Faculty of Medicine, Molecular Neurogenetics Group, Lund University, Lund, Sweden., Stamp E; Department of Experimental Medical Sciences, Faculty of Medicine, Stem Cells, Aging and Neurodegeneration Group, Lund University, Lund, Sweden.; Lund Stem Cell Center, Lund, Sweden., Ahlenius H; Department of Experimental Medical Sciences, Faculty of Medicine, Stem Cells, Aging and Neurodegeneration Group, Lund University, Lund, Sweden.; Lund Stem Cell Center, Lund, Sweden.
المصدر:	Developmental neurobiology [Dev Neurobiol] 2024 Jul; Vol. 84 (3), pp. 128-141. Date of Electronic Publication: 2024 Apr 14.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Wiley Subscription Services, Inc Country of Publication: United States NLM ID: 101300215 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1932-846X (Electronic) Linking ISSN: 19328451 NLM ISO Abbreviation: Dev Neurobiol Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Hoboken, NJ : Wiley Subscription Services, Inc.
مواضيع طبية MeSH:	Aging/metabolism , Aging/physiology , CX3C Chemokine Receptor 1/metabolism , CX3C Chemokine Receptor 1/genetics , Microglia/metabolism , Neurogenesis/physiology, Animals ; Mice ; Brain/metabolism ; Mice, Inbred C57BL ; Mice, Transgenic ; Receptors, Chemokine/metabolism ; Receptors, Chemokine/genetics ; Transcriptional Activation/physiology ; Humans
مستخلص:	Adult neurogenesis continues throughout life but declines dramatically with age and in neurodegenerative disorders such as Alzheimer's disease. In parallel, microglia become activated resulting in chronic inflammation in the aged brain. A unique type of microglia, suggested to support neurogenesis, exists in the subventricular zone (SVZ), but little is known how they are affected by aging. We analyzed the transcriptome of aging microglia and identified a unique neuroprotective activation profile in aged SVZ microglia, which is partly shared with disease-associated microglia (DAM). CX3C motif chemokine receptor 1 (CX3CR1) is characteristically expressed by brain microglia where it directs migration to targets for phagocytosis. We show that Cx3cr1 expression, as in DAM, is downregulated in old SVZ microglia and that heterozygous Cx3cr1 mice have increased proliferation and neuroblast number in the aged SVZ but not in the dentate gyrus, identifying CX3CR1 signaling as a novel age and brain region-specific regulator of neurogenesis. (© 2024 The Authors. Developmental Neurobiology published by Wiley Periodicals LLC.)
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معلومات مُعتمدة:	2018-02695 Vetenskapsrådet
فهرسة مساهمة:	Keywords: CX3C motif chemokine receptor 1; aging; disease‐associated microglia; microglia; neurogenesis; subventricular zone
المشرفين على المادة:	0 (CX3C Chemokine Receptor 1) 0 (Cx3cr1 protein, mouse) 0 (Receptors, Chemokine) 0 (CX3CR1 protein, human)
تواريخ الأحداث:	Date Created: 20240415 Date Completed: 20240716 Latest Revision: 20240815
رمز التحديث:	20240815
DOI:	10.1002/dneu.22939
PMID:	38616340
قاعدة البيانات:	MEDLINE

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تدمد:	1932-846X
DOI:	10.1002/dneu.22939