دورية أكاديمية
أعرض في EDS

Atypical anti-glomerular basement membrane disease with membranous hyperplasia: diagnostic challenges and treatment variability.

التفاصيل البيبلوغرافية
العنوان: Atypical anti-glomerular basement membrane disease with membranous hyperplasia: diagnostic challenges and treatment variability.
المؤلفون: Tong R; Nephrology Department, Chinese PLA Southern Theater Command General Hospital, 510010, Guangzhou, China., Luo Z; Nephrology Department, Chinese PLA Southern Theater Command General Hospital, 510010, Guangzhou, China., Zhong X; Nephrology Department, Chinese PLA Southern Theater Command General Hospital, 510010, Guangzhou, China., Fan L; Nephrology Department, Chinese PLA Southern Theater Command General Hospital, 510010, Guangzhou, China., Lai H; Pathology Department, Chinese PLA Southern Theater Command General Hospital, 510010, Guangzhou, China., Shen M; Nephrology Department, Chinese PLA Southern Theater Command General Hospital, 510010, Guangzhou, China., Huang Y; Nephrology Department, Chinese PLA Southern Theater Command General Hospital, 510010, Guangzhou, China. h.yuanhang@163.com.
المصدر: BMC nephrology [BMC Nephrol] 2024 Apr 15; Vol. 25 (1), pp. 132. Date of Electronic Publication: 2024 Apr 15.
نوع المنشور: Case Reports; Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100967793 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2369 (Electronic) Linking ISSN: 14712369 NLM ISO Abbreviation: BMC Nephrol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2000-
مواضيع طبية MeSH: Anti-Glomerular Basement Membrane Disease*/complications , Anti-Glomerular Basement Membrane Disease*/diagnosis , Anti-Glomerular Basement Membrane Disease*/therapy, Male ; Humans ; Adult ; Hyperplasia/pathology ; Kidney/pathology ; Autoantibodies ; Proteinuria/etiology ; Proteinuria/complications ; Cyclophosphamide/therapeutic use
مستخلص: This case report presents a detailed analysis of a 31-year-old male patient who presented with a complex array of clinical symptoms, including proteinuria, hematuria, edema, and kidney insufficiency. Despite undergoing multiple tests, the results for anti-glomerular basement membrane antibodies yielded negative findings. Subsequently, kidney biopsy pathology revealed a distinct diagnosis of atypical anti-glomerular basement membrane (anti-GBM) disease with membrane hyperplasia. Treatment was initiated with a comprehensive approach involving high doses of corticosteroids therapy and cyclophosphamide (CTX). However, contrary to expectations, the patient's kidney function exhibited rapid deterioration following this therapeutic regimen. The culmination of these complications necessitated a pivotal transition to maintenance hemodialysis. This case underscores the intricate challenges associated with diagnosing and managing rare and atypical presentations of kidney disorders. The negative anti-GBM antibody results and subsequent identification of atypical anti-GBM nephropathy highlight the need for tailored diagnostic strategies to discern subtle nuances within complex clinical scenarios. Additionally, the unexpected response to the treatment regimen emphasizes the potential variability in individual patient responses, underlining the necessity for vigilant monitoring and adaptable treatment strategies. This case report contributes to the evolving understanding of atypical kidney pathologies and the complexities involved in their management.
(© 2024. The Author(s).)
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فهرسة مساهمة: Keywords: Atypical anti-glomerular basement membrane disease; Kidney; Membranous hyperplasia
المشرفين على المادة: 0 (Autoantibodies)
8N3DW7272P (Cyclophosphamide)
تواريخ الأحداث: Date Created: 20240415 Date Completed: 20240417 Latest Revision: 20240501
رمز التحديث: 20240502
مُعرف محوري في PubMed: PMC11017607
DOI: 10.1186/s12882-024-03571-5
PMID: 38622525
قاعدة البيانات: MEDLINE
الوصف
تدمد:1471-2369
DOI:10.1186/s12882-024-03571-5