دورية أكاديمية
أعرض في EDS

Methicillin-Resistant Staphylococcus aureus Carriage among Neonate Mothers, Healthcare Workers, and Environmental Samples in Neonatal Intensive Care Units: A Systematic Review.

التفاصيل البيبلوغرافية
العنوان: Methicillin-Resistant Staphylococcus aureus Carriage among Neonate Mothers, Healthcare Workers, and Environmental Samples in Neonatal Intensive Care Units: A Systematic Review.
المؤلفون: Keneh NK; Department of Microbiology and Parasitology, University of Buea, Buea, Cameroon.; Laboratory for Emerging Infectious Diseases, University of Buea, Buea, Southwest Region, Cameroon., Kenmoe S; Department of Microbiology and Parasitology, University of Buea, Buea, Cameroon., Bowo-Ngandji A; Department of Microbiology, The University of Yaounde I, Yaounde, Cameroon., Akoachere JTK; Department of Microbiology and Parasitology, University of Buea, Buea, Cameroon., Kamga HG; Faculty of Medicine and Biomedical Sciences, The University of Yaounde I, Yaoundé, Cameroon., Ndip RN; Department of Microbiology and Parasitology, University of Buea, Buea, Cameroon., Ebogo-Belobo JT; Center for Research in Health and Priority Pathologies, Institute of Medical Research and Medicinal Plants Studies, Yaounde, Cameroon., Kengne-Ndé C; Epidemiological Surveillance, Evaluation and Research Unit, National AIDS Control Committee, Douala, Cameroon., Mbaga DS; Department of Microbiology, The University of Yaounde I, Yaounde, Cameroon., Tendongfor N; Department of Public Health and Hygiene, University of Buea, P.O. Box 63, Buea, Cameroon., Assam JPA; Department of Microbiology, The University of Yaounde I, Yaounde, Cameroon., Ndip LM; Department of Microbiology and Parasitology, University of Buea, Buea, Cameroon.; Laboratory for Emerging Infectious Diseases, University of Buea, Buea, Southwest Region, Cameroon., Esemu SN; Department of Microbiology and Parasitology, University of Buea, Buea, Cameroon.; Laboratory for Emerging Infectious Diseases, University of Buea, Buea, Southwest Region, Cameroon.
المصدر: BioMed research international [Biomed Res Int] 2024 Apr 08; Vol. 2024, pp. 5675786. Date of Electronic Publication: 2024 Apr 08 (Print Publication: 2024).
نوع المنشور: Systematic Review; Journal Article
اللغة: English
بيانات الدورية: Publisher: Hindawi Pub. Co Country of Publication: United States NLM ID: 101600173 Publication Model: eCollection Cited Medium: Internet ISSN: 2314-6141 (Electronic) NLM ISO Abbreviation: Biomed Res Int
أسماء مطبوعة: Original Publication: New York, NY : Hindawi Pub. Co.
مواضيع طبية MeSH: Methicillin-Resistant Staphylococcus aureus*/isolation & purification , Intensive Care Units, Neonatal* , Staphylococcal Infections*/microbiology , Staphylococcal Infections*/epidemiology , Mothers* , Health Personnel*, Humans ; Infant, Newborn ; Female ; Carrier State/microbiology
مستخلص: Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a significant cause of morbidity and mortality among neonates admitted to neonatal intensive care units (NICUs). The MRSA colonization of neonates, attributed to various sources, including mothers, healthcare workers, and environmental surfaces, can lead to severe infection, prolonged hospital stays, and even death, imposing substantial economic burdens. Given the pressing need to mitigate MRSA spread in these vulnerable environments, further examination of the subject is warranted. This systematic review is aimed at synthesizing available evidence on MRSA carriage proportions among mothers of newborns, healthcare workers, and environmental surfaces in NICUs. Methodology . We included observational studies published in English or French from database inception to March 21, 2023. These studies focused on MRSA in nonoutbreak NICU settings, encompassing healthy neonate mothers and healthcare workers, and environmental surfaces. Literature search involved systematic scanning of databases, including Medline, Embase, Web of Science, Global Health, and Global Index Medicus. The quality of the selected studies was assessed using the Hoy et al. critical appraisal scale. The extracted data were summarized to calculate the pooled proportion of MRSA positives, with a 95% confidence interval (CI) based on the DerSimonian and Laird random-effects model.
Results: A total of 1891 articles were retrieved from which 16 studies were selected for inclusion. Most of the studies were from high-income countries. The pooled proportion of MRSA carriage among 821 neonate mothers across four countries was found to be 2.1% (95% CI: 0.3-5.1; I 2 = 76.6%, 95% CI: 36.1-91.5). The proportion of MRSA carriage among 909 HCWs in eight countries was determined to be 9.5% (95% CI: 3.1-18.4; I 2 = 91.7%, 95% CI: 87.1-94.6). The proportion of MRSA carriage among HCWs was highest in the Western Pacific Region, at 50.00% (95% CI: 23.71-76.29). In environmental specimens from five countries, a pooled proportion of 16.6% (95% CI: 3.5-36.0; I 2 = 97.7%, 95% CI: 96.6-98.4) was found to be MRSA-positive.
Conclusion: With a significant heterogeneity, our systematic review found high MRSA carriage rates in neonate mothers, healthcare workers, and across various environmental surfaces in NICUs, posing a potential risk of nosocomial infections. Urgent interventions, including regular screening and decolonization of MRSA carriers, reinforcing infection control measures, and enhancing cleaning and disinfection procedures within NICUs, are crucial. This trial is registered with CRD42023407114.
Competing Interests: The authors declare that they have no conflicts of interest.
(Copyright © 2024 Nene Kaah Keneh et al.)
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تواريخ الأحداث: Date Created: 20240416 Date Completed: 20240807 Latest Revision: 20240807
رمز التحديث: 20240808
مُعرف محوري في PubMed: PMC11018372
DOI: 10.1155/2024/5675786
PMID: 38623471
قاعدة البيانات: MEDLINE
الوصف
تدمد:2314-6141
DOI:10.1155/2024/5675786