دورية أكاديمية
Sinonasal manifestations of granulomatosis with polyangiitis: A retrospective analysis.
| العنوان: | Sinonasal manifestations of granulomatosis with polyangiitis: A retrospective analysis. |
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| المؤلفون: | Tateyama K; Department of Otolaryngology Head and Neck Surgery, Oita University Faculty of Medicine, Oita, Japan., Umemoto S; Department of Otolaryngology Head and Neck Surgery, Oita University Faculty of Medicine, Oita, Japan., Iwano S; Department of Otolaryngology Head and Neck Surgery, Oita University Faculty of Medicine, Oita, Japan., Hirano T; Department of Otolaryngology Head and Neck Surgery, Oita University Faculty of Medicine, Oita, Japan. Electronic address: thirano@oita-u.ac.jp., Suzuki M; Department of Otolaryngology Head and Neck Surgery, Oita University Faculty of Medicine, Oita, Japan. |
| المصدر: | Auris, nasus, larynx [Auris Nasus Larynx] 2024 Aug; Vol. 51 (4), pp. 625-630. Date of Electronic Publication: 2024 Apr 15. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 7708170 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1476 (Electronic) Linking ISSN: 03858146 NLM ISO Abbreviation: Auris Nasus Larynx Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Science Original Publication: Tokyo, Society for Promotion of International Otorhinolaryngology. |
| مواضيع طبية MeSH: | Granulomatosis with Polyangiitis*/complications , Granulomatosis with Polyangiitis*/diagnostic imaging , Granulomatosis with Polyangiitis*/pathology , Tomography, X-Ray Computed* , Antibodies, Antineutrophil Cytoplasmic*/immunology , Nasal Mucosa*/pathology , Nasal Mucosa*/diagnostic imaging, Humans ; Middle Aged ; Male ; Female ; Retrospective Studies ; Aged ; Adult ; Paranasal Sinuses/diagnostic imaging ; Paranasal Sinuses/pathology ; Myeloblastin/immunology ; Paranasal Sinus Diseases/diagnostic imaging ; Paranasal Sinus Diseases/etiology ; Paranasal Sinus Diseases/pathology |
| مستخلص: | Objective: This study aimed to examine the characteristics of nasal and imaging findings of sinonasal lesions in granulomatosis with polyangiitis (GPA) patients and how these lesions change over time in both the active and remission phases of the disease. Methods: We retrospectively reviewed GPA patients with sinonasal lesions who were followed up at our department between January 2005 and December 2020. The following data were collected: age, sex, symptoms at initial presentation, anti-neutrophil cytoplasmic antibody (ANCA) type, and histopathological, nasal (initial and follow-up), and imaging (initial and follow-up) findings. Results: This study included 17 patients with GPA aged 30 to 79 years. Computed tomography (CT) of the sinuses showed mucosal thickening in 16 patients, bone thickening in 12, bone destruction in 4, and an orbital invasion mass in 3 at the time of diagnosis. After initiating treatment, mucosal thickening of the sinuses improved in 3 of 16 patients and remained unchanged in 13. Bone thickening at the time of diagnosis remained unchanged in 10 of 12 patients and worsened in 2; 1 patient displayed newly developed bone thickening. Destructive nasal findings on CT were positive for proteinase 3-ANCA. Conclusions: Our study revealed that mucosal thickening, bone thickening, bone destruction, and orbital invasion mass were major CT findings in patients with GPA. Intranasal findings such as granulations, crusting, and necrosis were seen in the active phase; moreover, saddle nose, loss of turbinate, and nasal septal perforation were subsequently seen in the course of the disease. Sinonasal findings of GPA vary depending on the disease stage and period. Competing Interests: Declaration of competing interest The authors declare that they have no competing interests. (Copyright © 2024. Published by Elsevier B.V.) |
| فهرسة مساهمة: | Keywords: Anti-neutrophil cytoplasmic antibody; Granulomatosis with polyangiitis; Sinonasal findings |
| المشرفين على المادة: | 0 (Antibodies, Antineutrophil Cytoplasmic) EC 3.4.21.76 (Myeloblastin) |
| تواريخ الأحداث: | Date Created: 20240416 Date Completed: 20240729 Latest Revision: 20240729 |
| رمز التحديث: | 20240730 |
| DOI: | 10.1016/j.anl.2024.04.002 |
| PMID: | 38626696 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1879-1476 |
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| DOI: | 10.1016/j.anl.2024.04.002 |