دورية أكاديمية
Development and validation of an alternative procedure for quantitative quality control analysis of 99m Tc-radiopharmaceuticals using a Geiger Müller counter.
| العنوان: | Development and validation of an alternative procedure for quantitative quality control analysis of 99m Tc-radiopharmaceuticals using a Geiger Müller counter. |
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| المؤلفون: | Gonzalez MM; Departamento de Producción de Radioisótopos, Centro Integral de Medicina Nuclear y Radiofarmacia de Bariloche, Comisión Nacional de Energía Atómica (CNEA), San Carlos de Bariloche, Río Negro, Argentina; Instituto de Nanociencia y Nanotecnología, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Comisión Nacional de Energía Atómica (CNEA), San Carlos de Bariloche, Río Negro, Argentina., Poma AL; Servicio de Medicina Nuclear, Centro Integral de Medicina Nuclear y Radiofarmacia de Bariloche, Comisión Nacional de Energía Atómica (CNEA), San Carlos de Bariloche, Río Negro, Argentina., Cuello N; Departamento de Producción de Radioisótopos, Centro Integral de Medicina Nuclear y Radiofarmacia de Bariloche, Comisión Nacional de Energía Atómica (CNEA), San Carlos de Bariloche, Río Negro, Argentina., Soldati AL; Departamento de Producción de Radioisótopos, Centro Integral de Medicina Nuclear y Radiofarmacia de Bariloche, Comisión Nacional de Energía Atómica (CNEA), San Carlos de Bariloche, Río Negro, Argentina; Instituto de Nanociencia y Nanotecnología, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Comisión Nacional de Energía Atómica (CNEA), San Carlos de Bariloche, Río Negro, Argentina. Electronic address: analia.soldati@intecnus.org.ar. |
| المصدر: | Revista espanola de medicina nuclear e imagen molecular [Rev Esp Med Nucl Imagen Mol (Engl Ed)] 2024 May-Jun; Vol. 43 (3), pp. 500006. Date of Electronic Publication: 2024 Apr 16. |
| نوع المنشور: | Journal Article; Validation Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier España Country of Publication: Spain NLM ID: 101770941 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2253-8089 (Electronic) Linking ISSN: 22538089 NLM ISO Abbreviation: Rev Esp Med Nucl Imagen Mol (Engl Ed) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Barcelona] : Elsevier España, ©2012- |
| مواضيع طبية MeSH: | Radiopharmaceuticals*/analysis , Quality Control*, Technetium/analysis ; Calibration ; Sodium Pertechnetate Tc 99m/analysis |
| مستخلص: | Background and Objectives: In a hospital radiopharmacy with 2a operational level, including the preparation of radiopharmaceuticals from prepared and approved reagent kits, it is common to have a single activimeter or dose calibrator for labeling and fractionation, and to perform the quality controls of the 99m Tc-radiopharmaceuticals. In certain cases, the accumulation of radioactive material or accidental contamination of the work area causes the background to exceed the limits to carry out the radiochemical purity analyses and it is necessary to look for viable alternatives. In this work, a Geiger Müller detector (equipped with a probe for measuring surface contamination) frequently used for radioprotection purposes, was validated as an alternative and its performance was compared against the activimeter for 99m Tc-radiopharmaceuticals. Materials and Methods: Using [ 99m Tc]pertechnetate, systematic studies of error analyses and detector response to activity concentration, activity and measurement time were carried out in liquid matrices and in paper. The results were compared against an activimeter calibrated for [ 99m Tc]Tc. Results: The developed method was used to determine the radiochemical purity of the compounds [ 99m Tc]Tc-MDP and [ 99m Tc]Tc-MIBI by ascending paper chromatography tests, obtaining comparable values to those measured with an activimeter in the same system (within 1% uncertainty) and using the method of vial partitioning in a dedicated equipment. Conclusions: This work demonstrates that a Geiger Müller detector with a probe for measuring surface contamination can be adequately used to replace other equipment in the control of radiochemical purity in the hospital radiopharmacy. (Copyright © 2024 Sociedad Española de Medicina Nuclear e Imagen Molecular. Published by Elsevier España, S.L.U. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Control de calidad; Conventional radiopharmacy; Geiger probe; Pureza radioquímica; Quality control; Radiochemical purity; Radiofarmacia convencional; Radiofármacos tecneciados; Sonda Geiger; Tc radiopharmaceuticals |
| المشرفين على المادة: | 0 (Radiopharmaceuticals) 7440-26-8 (Technetium) A0730CX801 (Sodium Pertechnetate Tc 99m) |
| تواريخ الأحداث: | Date Created: 20240416 Date Completed: 20240522 Latest Revision: 20240522 |
| رمز التحديث: | 20240523 |
| DOI: | 10.1016/j.remnie.2024.500006 |
| PMID: | 38626842 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 2253-8089 |
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| DOI: | 10.1016/j.remnie.2024.500006 |