دورية أكاديمية
أعرض في EDS

Genetic barriers more than environmental associations explain Serratia marcescens population structure.

التفاصيل البيبلوغرافية
العنوان: Genetic barriers more than environmental associations explain Serratia marcescens population structure.
المؤلفون: Sterzi L; Department of Biomedical and Clinical Sciences, Pediatric Clinical Research Center 'Romeo and Enrica Invernizzi', Università Di Milano, 20157, Milan, Italy., Nodari R; Department of Biomedical and Clinical Sciences, Pediatric Clinical Research Center 'Romeo and Enrica Invernizzi', Università Di Milano, 20157, Milan, Italy., Di Marco F; Emerging Bacterial Pathogens Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy., Ferrando ML; Emerging Bacterial Pathogens Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy., Saluzzo F; Emerging Bacterial Pathogens Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy., Spitaleri A; Neurogenomics Research Centre, Human Technopole, Milan, Italy., Allahverdi H; Department of Biomedical and Clinical Sciences, Pediatric Clinical Research Center 'Romeo and Enrica Invernizzi', Università Di Milano, 20157, Milan, Italy., Papaleo S; Department of Biomedical and Clinical Sciences, Pediatric Clinical Research Center 'Romeo and Enrica Invernizzi', Università Di Milano, 20157, Milan, Italy., Panelli S; Department of Biomedical and Clinical Sciences, Pediatric Clinical Research Center 'Romeo and Enrica Invernizzi', Università Di Milano, 20157, Milan, Italy., Rimoldi SG; Laboratorio di Microbiologia Clinica, Virologia e Diagnostica delle Bioemergenze, ASST Fatebenefratelli Sacco, Milan, Italy., Batisti Biffignandi G; Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy., Corbella M; Department of Microbiology & Virology, Fondazione IRCCS Policlinico San Matteo, Viale Camillo Golgi 19, 27100, Pavia, Italy., Cavallero A; Microbiology Unit, Fondazione IRCCS San Gerardo, Monza, Italy., Prati P; Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna (IZSLER), Pavia, Italy., Farina C; Laboratory of Microbiology and Virology, Azienda Socio-Sanitaria Territoriale (ASST) Papa Giovanni XXIII, Bergamo, Italy., Cirillo DM; Emerging Bacterial Pathogens Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy., Zuccotti G; Department of Biomedical and Clinical Sciences, Pediatric Clinical Research Center 'Romeo and Enrica Invernizzi', Università Di Milano, 20157, Milan, Italy.; Department of Paediatrics, Children's Hospital 'V. Buzzi', Milano, Italy., Bandi C; Department of Biosciences and Pediatric Clinical Research Center 'Romeo Ed Enrica Invernizzi', University of Milan, 20133, Milan, Italy., Comandatore F; Department of Biomedical and Clinical Sciences, Pediatric Clinical Research Center 'Romeo and Enrica Invernizzi', Università Di Milano, 20157, Milan, Italy. francesco.comandatore@unimi.it.
المصدر: Communications biology [Commun Biol] 2024 Apr 17; Vol. 7 (1), pp. 468. Date of Electronic Publication: 2024 Apr 17.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London, United Kingdom : Nature Publishing Group UK, [2018]-
مواضيع طبية MeSH: Serratia marcescens*/genetics , Genetic Variation*, Ecosystem ; Gene Flow ; Genomics
مستخلص: Bacterial species often comprise well-separated lineages, likely emerged and maintained by genetic isolation and/or ecological divergence. How these two evolutionary actors interact in the shaping of bacterial population structure is currently not fully understood. In this study, we investigate the genetic and ecological drivers underlying the evolution of Serratia marcescens, an opportunistic pathogen with high genomic flexibility and able to colonise diverse environments. Comparative genomic analyses reveal a population structure composed of five deeply-demarcated genetic clusters with open pan-genome but limited inter-cluster gene flow, partially explained by Restriction-Modification (R-M) systems incompatibility. Furthermore, a large-scale research on hundred-thousands metagenomic datasets reveals only a partial habitat separation of the clusters. Globally, two clusters only show a separate gene composition coherent with ecological adaptations. These results suggest that genetic isolation has preceded ecological adaptations in the shaping of the species diversity, an evolutionary scenario coherent with the Evolutionary Extended Synthesis.
(© 2024. The Author(s).)
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تواريخ الأحداث: Date Created: 20240417 Date Completed: 20240419 Latest Revision: 20240425
رمز التحديث: 20240425
مُعرف محوري في PubMed: PMC11023947
DOI: 10.1038/s42003-024-06069-w
PMID: 38632370
قاعدة البيانات: MEDLINE
الوصف
تدمد:2399-3642
DOI:10.1038/s42003-024-06069-w