دورية أكاديمية
Chronic hyperglycemia and intracranial meningiomas.
| العنوان: | Chronic hyperglycemia and intracranial meningiomas. |
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| المؤلفون: | Orešković D; Department of Neurosurgery, Clinical Hospital Dubrava, Zagreb, Croatia. darkoreskov@gmail.com., Madero Pohlen A; Department of Neurosurgery, University Hospital de la Princesa, Madrid, Spain., Cvitković I; Department of Neurosurgery, University Hospital Center Split, Split, Croatia., Alen JF; Department of Neurosurgery, University Hospital de la Princesa, Madrid, Spain., Raguž M; Department of Neurosurgery, Clinical Hospital Dubrava, Zagreb, Croatia., Álvarez-Sala de la Cuadra A; Department of Neurosurgery, University Hospital de la Princesa, Madrid, Spain., Bazarra Castro GJ; Department of Neurosurgery, University Hospital de la Princesa, Madrid, Spain., Bušić Z; Department of Neurosurgery, University Hospital Center Split, Split, Croatia., Konstantinović I; Department of Neurosurgery, University Hospital Center Split, Split, Croatia., Ledenko V; Department of Neurosurgery, University Hospital Center Split, Split, Croatia., Martínez Macho C; Department of Neurosurgery, University Hospital de la Princesa, Madrid, Spain., Müller D; Department of Pathology, Clinical Hospital Dubrava, Zagreb, Croatia., Žarak M; Clinical Department of Laboratory Diagnostics, Clinical Hospital Dubrava, Zagreb, Croatia.; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia., Jovanov-Milosevic N; Department of Biology, School of Medicine, University of Zagreb, Zagreb, Croatia.; Scientific Centre of Excellence for Basic, Clinical and Translational Neuroscience, School of Medicine, Croatian Institute for Brain Research, University of Zagreb, Zagreb, Croatia., Chudy D; Department of Neurosurgery, Clinical Hospital Dubrava, Zagreb, Croatia.; Scientific Centre of Excellence for Basic, Clinical and Translational Neuroscience, School of Medicine, Croatian Institute for Brain Research, University of Zagreb, Zagreb, Croatia., Marinović T; Department of Neurosurgery, Clinical Hospital Dubrava, Zagreb, Croatia.; Department of Neurology and Neurosurgery, Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia. |
| المصدر: | BMC cancer [BMC Cancer] 2024 Apr 17; Vol. 24 (1), pp. 488. Date of Electronic Publication: 2024 Apr 17. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 100967800 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2407 (Electronic) Linking ISSN: 14712407 NLM ISO Abbreviation: BMC Cancer Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : BioMed Central, [2001- |
| مواضيع طبية MeSH: | Meningioma*/surgery , Meningeal Neoplasms*/surgery , Hyperglycemia*, Humans ; Glycated Hemoglobin ; Glucose |
| مستخلص: | Meningiomas are among the most common primary tumors of the central nervous system. Previous research into the meningioma histological appearance, genetic markers, transcriptome and epigenetic landscape has revealed that benign meningiomas significantly differ in their glucose metabolism compared to aggressive lesions. However, a correlation between the systemic glucose metabolism and the metabolism of the tumor hasn't yet been found. We hypothesized that chronic levels of glycaemia (approximated with glycated hemoglobin (HbA1c)) are different in patients with aggressive and benign meningiomas. The study encompassed 71 patients with de novo intracranial meningiomas, operated on in three European hospitals, two in Croatia and one in Spain. Our results show that patients with WHO grade 2 meningiomas had significantly higher HbA1c values compared to patients with grade 1 lesions (P = 0.0290). We also found a significant number of patients (19/71; 26.7%) being hyperglycemic, harboring all the risks that such a condition entails. Finally, we found a significant correlation between our patients' age and their preoperative HbA1c levels (P = 0.0008, ρ(rho) = 0.388), suggesting that older meningioma patients are at a higher risk of having their glycaemia severely dysregulated. These findings are especially important considering the current routine and wide-spread use of corticosteroids as anti-edematous treatment. Further research in this area could lead to better understanding of meningiomas and have immediate clinical impact. (© 2024. The Author(s).) |
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| فهرسة مساهمة: | Keywords: Dexamethasone; Hyperglycaemia; Meningioma |
| المشرفين على المادة: | 0 (Glycated Hemoglobin) IY9XDZ35W2 (Glucose) |
| تواريخ الأحداث: | Date Created: 20240417 Date Completed: 20240419 Latest Revision: 20240425 |
| رمز التحديث: | 20240425 |
| مُعرف محوري في PubMed: | PMC11022447 |
| DOI: | 10.1186/s12885-024-12243-4 |
| PMID: | 38632533 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1471-2407 |
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| DOI: | 10.1186/s12885-024-12243-4 |