دورية أكاديمية
A Prognostic Survival Model Incorporating Patient-Reported Outcomes for Transplant-Ineligible Patients With Multiple Myeloma.
| العنوان: | A Prognostic Survival Model Incorporating Patient-Reported Outcomes for Transplant-Ineligible Patients With Multiple Myeloma. |
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| المؤلفون: | Mian H; Department of Oncology, McMaster University, Hamilton, ON, Canada., Seow H; Department of Oncology, McMaster University, Hamilton, ON, Canada., Balitsky AK; Department of Oncology, McMaster University, Hamilton, ON, Canada., Cheung MC; Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada., Gayowsky A; ICES, McMaster University, Hamilton, ON, Canada., Tay J; Department of Medicine, University of Calgary, Calgary, AB, Canada., Wildes TM; Department of Medicine, University of Nebraska Medical Center/Nebraska Medicine, Omaha, NE, USA., McCurdy A; Department of Medicine, The Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada., Visram A; Department of Medicine, The Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada., Sandhu I; Department of Medicine, University of Edmonton, Edmonton, AB, Canada., Sutradhar R; Institute for Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada.; Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. |
| المصدر: | The oncologist [Oncologist] 2024 Jun 03; Vol. 29 (6), pp. 519-526. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 9607837 Publication Model: Print Cited Medium: Internet ISSN: 1549-490X (Electronic) Linking ISSN: 10837159 NLM ISO Abbreviation: Oncologist Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2022- : Oxford : Oxford University Press Original Publication: Dayton, Ohio : AlphaMed Press, c1996- |
| مواضيع طبية MeSH: | Multiple Myeloma*/mortality , Multiple Myeloma*/therapy , Patient Reported Outcome Measures*, Humans ; Male ; Female ; Prognosis ; Aged ; Retrospective Studies ; Aged, 80 and over ; Middle Aged |
| مستخلص: | Developing prognostic tools specifically for patients themselves represents an important step in empowering patients to engage in shared decision-making. Incorporating patient-reported outcomes may improve the accuracy of these prognostic tools. We conducted a retrospective population-based study of transplant-ineligible (TIE) patients with multiple myeloma (MM) diagnosed between January 2007 and December 2018. A multivariable Cox regression model was developed to predict the risk of death within 1-year period from the index date. We identified 2356 patients with TIE MM. The following factors were associated with an increased risk of death within 1 year: age > 80 (HR 1.11), history of heart failure (HR 1.52), "CRAB" at diagnosis (HR 1.61), distance to cancer center (HR 1.25), prior radiation (HR 1.48), no proteosome inhibitor/immunomodulatory therapy usage (HR 1.36), recent emergency department (HR 1.55) or hospitalization (HR 2.13), poor performance status (ECOG 3-4 HR 1.76), and increasing number of severe symptoms (HR 1.56). Model discrimination was high with C-statistic of 0.74, and calibration was very good. To our knowledge, this represents one of the first prognostic models developed in MM incorporating patient-reported outcomes. This survival prognostic tool may improve communication regarding prognosis and shared decision-making among older adults with MM and their health care providers. (© The Author(s) 2024. Published by Oxford University Press.) |
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| معلومات مُعتمدة: | Ontario Ministry of Health and the Ministry |
| فهرسة مساهمة: | Keywords: multiple myeloma; patient-reported outcomes; prognostic tool; survival |
| تواريخ الأحداث: | Date Created: 20240418 Date Completed: 20240603 Latest Revision: 20240605 |
| رمز التحديث: | 20240605 |
| مُعرف محوري في PubMed: | PMC11145018 |
| DOI: | 10.1093/oncolo/oyae041 |
| PMID: | 38636951 |
| قاعدة البيانات: | MEDLINE |
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