Diet switch pre-vaccination improves immune response and metabolic status in formerly obese mice.

التفاصيل البيبلوغرافية
العنوان:	Diet switch pre-vaccination improves immune response and metabolic status in formerly obese mice.
المؤلفون:	Honce R; Department of Host Microbe Interactions, St Jude Children's Research Hospital, Memphis, TN, USA.; Vermont Lung Center, Division of Pulmonology and Critical Care, Department of Medicine, Larner College of Medicine, University of Vermont, Burlington, VT, USA., Vazquez-Pagan A; Department of Host Microbe Interactions, St Jude Children's Research Hospital, Memphis, TN, USA.; Graduate School of Biomedical Sciences, St Jude Children's Research Hospital, Memphis, TN, USA.; Weill Cornell Medicine, New York City, NY, USA.; Noguchi Medical Research Institute (NMRI), Accra, Ghana., Livingston B; Department of Host Microbe Interactions, St Jude Children's Research Hospital, Memphis, TN, USA., Mandarano AH; Department of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA., Wilander BA; Graduate School of Biomedical Sciences, St Jude Children's Research Hospital, Memphis, TN, USA.; Department of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA., Cherry S; Department of Host Microbe Interactions, St Jude Children's Research Hospital, Memphis, TN, USA., Hargest V; Department of Host Microbe Interactions, St Jude Children's Research Hospital, Memphis, TN, USA., Sharp B; Department of Host Microbe Interactions, St Jude Children's Research Hospital, Memphis, TN, USA., Brigleb PH; Department of Host Microbe Interactions, St Jude Children's Research Hospital, Memphis, TN, USA., Kirkpatrick Roubidoux E; Department of Host Microbe Interactions, St Jude Children's Research Hospital, Memphis, TN, USA., Van de Velde LA; Department of Host Microbe Interactions, St Jude Children's Research Hospital, Memphis, TN, USA., Skinner RC; Division of Natural Sciences and Mathematics, University of the Ozarks, Clarksville, AR, USA.; Department of Nutrition and Food Sciences, College of Agriculture and Life Sciences, University of Vermont, Burlington, VT, USA., McGargill MA; Department of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA., Thomas PG; Department of Host Microbe Interactions, St Jude Children's Research Hospital, Memphis, TN, USA., Schultz-Cherry S; Department of Host Microbe Interactions, St Jude Children's Research Hospital, Memphis, TN, USA. stacey.schultz-cherry@stjude.org.
المصدر:	Nature microbiology [Nat Microbiol] 2024 Jun; Vol. 9 (6), pp. 1593-1606. Date of Electronic Publication: 2024 Apr 18.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101674869 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2058-5276 (Electronic) Linking ISSN: 20585276 NLM ISO Abbreviation: Nat Microbiol Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: [London] : Nature Publishing Group, [2016]-
مواضيع طبية MeSH:	Influenza Vaccines/immunology , Influenza Vaccines/administration & dosage , Diet, High-Fat/adverse effects , Obesity/immunology , Obesity/metabolism , Orthomyxoviridae Infections/immunology , Orthomyxoviridae Infections*/prevention & control, Animals ; Mice ; Mice, Inbred C57BL ; Vaccination ; Mice, Obese ; Leptin/metabolism ; Male ; Female ; Adiponectin/metabolism ; T-Lymphocytes/immunology
مستخلص:	Metabolic disease is epidemiologically linked to severe complications upon influenza virus infection, thus vaccination is a priority in this high-risk population. Yet, vaccine responses are less effective in these same hosts. Here we examined how the timing of diet switching from a high-fat diet to a control diet affected influenza vaccine efficacy in diet-induced obese mice. Our results demonstrate that the systemic meta-inflammation generated by high-fat diet exposure limited T cell maturation to the memory compartment at the time of vaccination, impacting the recall of effector memory T cells upon viral challenge. This was not improved with a diet switch post-vaccination. However, the metabolic dysfunction of T cells was reversed if weight loss occurred 4 weeks before vaccination, restoring a functional recall response. This corresponded with changes in the systemic obesity-related biomarkers leptin and adiponectin, highlighting the systemic and specific effects of diet on influenza vaccine immunogenicity. (© 2024. The Author(s), under exclusive licence to Springer Nature Limited.)
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معلومات مُعتمدة:	75N93019C00052 United States AI NIAID NIH HHS; 75N93021C00016 United States AI NIAID NIH HHS; HHSN27220140006C U.S. Department of Health & Human Services \| NIH \| National Institute of Allergy and Infectious Diseases (NIAID); 75N93019C00052 United States AI NIAID NIH HHS; 75N93021C00016 United States AI NIAID NIH HHS; AI140766-03 U.S. Department of Health & Human Services \| NIH \| National Institute of Allergy and Infectious Diseases (NIAID); F31AI161986 U.S. Department of Health & Human Services \| NIH \| National Institute of Allergy and Infectious Diseases (NIAID); 75N93019C00052 United States AI NIAID NIH HHS; 75N93021C00016 United States AI NIAID NIH HHS; HHSN27220140006C U.S. Department of Health & Human Services \| NIH \| National Institute of Allergy and Infectious Diseases (NIAID); T32AI106700-07 U.S. Department of Health & Human Services \| NIH \| National Institute of Allergy and Infectious Diseases (NIAID); T32AI106700-07 U.S. Department of Health & Human Services \| NIH \| National Institute of Allergy and Infectious Diseases (NIAID)
المشرفين على المادة:	0 (Influenza Vaccines) 0 (Leptin) 0 (Adiponectin)
تواريخ الأحداث:	Date Created: 20240418 Date Completed: 20240605 Latest Revision: 20240605
رمز التحديث:	20240606
DOI:	10.1038/s41564-024-01677-y
PMID:	38637722
قاعدة البيانات:	MEDLINE

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تدمد:	2058-5276
DOI:	10.1038/s41564-024-01677-y