دورية أكاديمية
Composite of a Stabilizer-Free Trimetallic Prussian Blue Analogue (PBA) and Polyaniline (PANI) on 3D Porous Nickel Foam for the Detection of Nitrofurantoin in Biological Fluids.
| العنوان: | Composite of a Stabilizer-Free Trimetallic Prussian Blue Analogue (PBA) and Polyaniline (PANI) on 3D Porous Nickel Foam for the Detection of Nitrofurantoin in Biological Fluids. |
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| المؤلفون: | Mukundan G; Department of Biomedical Engineering, Indian Institute of Technology, Hyderabad 502285, India., Badhulika S; Department of Electrical Engineering, Indian Institute of Technology, Hyderabad 502285, India. |
| المصدر: | ACS applied bio materials [ACS Appl Bio Mater] 2024 May 20; Vol. 7 (5), pp. 2924-2935. Date of Electronic Publication: 2024 Apr 18. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: ACS Publications Country of Publication: United States NLM ID: 101729147 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2576-6422 (Electronic) Linking ISSN: 25766422 NLM ISO Abbreviation: ACS Appl Bio Mater Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : ACS Publications, [2018]- |
| مواضيع طبية MeSH: | Aniline Compounds*/chemistry , Ferrocyanides*/chemistry , Nickel*/chemistry , Nitrofurantoin*/chemistry , Nitrofurantoin*/analysis , Materials Testing*, Porosity ; Humans ; Electrochemical Techniques ; Particle Size ; Biocompatible Materials/chemistry ; Biocompatible Materials/chemical synthesis ; Surface Properties |
| مستخلص: | Herein, a facile and highly effective nonenzymatic electrochemical sensing system is designed for the detection of the antibacterial drug nitrofurantoin (NFT). This electrocatalyst is a combination of a trimetallic Prussian blue analogue and conductive polyaniline coated onto a three-dimensional porous nickel foam substrate. A comprehensive set of physicochemical analyses have verified the successful synthesis. The fabricated electrochemical sensor exhibits an impressively low limit of detection (0.096 nM) and quantification (0.338 nM, S/N = 3.3), coupled with a wide linear range spanning from 0.1 nM to 5 mM and a sensitivity of 13.9 μA nM -1 cm -2 . This excellent performance is attributed to the collaborative effects of conducting properties of polyaniline (PANI) and the remarkable redox behavior of the Prussian blue analogue (PBA). When both are integrated into the nickel foam, they create a significantly enlarged surface area with numerous catalytic active sites, enhancing the sensor's efficiency. The sensor demonstrates a high degree of specificity for NFT, while effectively minimizing responses to potential interferences such as flutamide, ascorbic acid, glucose, dopamine, uric acid, and nitrophenol, even when present in 2-3-fold higher concentrations. Moreover, to validate its practical utility, the sensor underwent real sample analysis using synthetic urine, achieving outstanding recovery rates of 118 and 101%. |
| فهرسة مساهمة: | Keywords: Prussian blue analog; electrochemical sensing; nitrofurantoin; nonenzymatic; ue; voltammetry |
| المشرفين على المادة: | 0 (polyaniline) 0 (ferric ferrocyanide) |
| تواريخ الأحداث: | Date Created: 20240418 Date Completed: 20240520 Latest Revision: 20240612 |
| رمز التحديث: | 20240613 |
| DOI: | 10.1021/acsabm.3c01297 |
| PMID: | 38637912 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 2576-6422 |
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| DOI: | 10.1021/acsabm.3c01297 |