دورية أكاديمية
Grape seed proanthocyanidin extract promotes skeletal muscle fiber type transformation through modulation of cecal microbiota and enhanced butyric acid production.
| العنوان: | Grape seed proanthocyanidin extract promotes skeletal muscle fiber type transformation through modulation of cecal microbiota and enhanced butyric acid production. |
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| المؤلفون: | Li Y; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, P. R. China., Chen X; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, P. R. China., He J; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, P. R. China., Zheng P; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, P. R. China., Luo Y; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, P. R. China., Yu B; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, P. R. China., Chen D; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, P. R. China., Huang Z; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, P. R. China. |
| المصدر: | Journal of food science [J Food Sci] 2024 Jun; Vol. 89 (6), pp. 3788-3801. Date of Electronic Publication: 2024 Apr 18. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley on behalf of the Institute of Food Technologists Country of Publication: United States NLM ID: 0014052 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1750-3841 (Electronic) Linking ISSN: 00221147 NLM ISO Abbreviation: J Food Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Malden, Mass. : Wiley on behalf of the Institute of Food Technologists Original Publication: Champaign, Ill. Institute of Food Technologists |
| مواضيع طبية MeSH: | Proanthocyanidins*/pharmacology , Gastrointestinal Microbiome*/drug effects , Grape Seed Extract*/pharmacology , Mice, Inbred BALB C* , Butyric Acid*/metabolism , Butyric Acid*/pharmacology, Animals ; Male ; Mice ; Cecum/microbiology ; Cecum/metabolism ; Muscle Fibers, Skeletal/drug effects ; Muscle Fibers, Slow-Twitch/drug effects ; Muscle Fibers, Slow-Twitch/metabolism ; Muscle Fibers, Fast-Twitch/drug effects ; Muscle Fibers, Fast-Twitch/metabolism ; Muscle, Skeletal/drug effects ; Bacteria/drug effects ; Bacteria/classification |
| مستخلص: | The conversion of fast-twitch fibers into slow-twitch fibers within skeletal muscle plays a crucial role in improving physical stamina and safeguarding against metabolic disorders in individuals. Grape seed proanthocyanidin extract (GSPE) possesses numerous pharmacological and health advantages, effectively inhibiting the onset of chronic illnesses. However, there is a lack of research on the specific mechanisms by which GSPE influences muscle physiology and gut microbiota. This study aims to investigate the role of gut microbiota and their metabolites in GSPE regulation of skeletal muscle fiber type conversion. In this experiment, 54 male BALB/c mice were randomly divided into three groups: basal diet, basal diet supplemented with GSPE, and basal diet supplemented with GSPE and antibiotics. During the feeding period, glucose tolerance and forced swimming tests were performed. After euthanasia, samples of muscle and feces were collected for analysis. The results showed that GSPE increased the muscle mass and anti-fatigue capacity of the mice, as well as the expression of slow-twitch fibers. However, the beneficial effects of GSPE on skeletal muscle fibers disappeared after adding antibiotics to eliminate intestinal microorganisms, suggesting that GSPE may play a role by regulating intestinal microbial structure. In addition, GSPE increased the relative abundance of Blautia, Muribaculaceae, and Enterorhabdus, as well as butyrate production. Importantly, these gut microbes exhibited a significant positive correlation with the expression of slow-twitch muscle fibers. In conclusion, supplementation with GSPE can increase the levels of slow-twitch fibers by modulating the gut microbiota, consequently prolonging the duration of exercise before exhaustion. PRACTICAL APPLICATION: This research suggests that grape seed proanthocyanidin extract (GSPE) has potential applications in improving physical stamina and preventing metabolic disorders. By influencing the gut microbiota and increasing butyric acid production, GSPE contributes to the conversion of fast-twitch muscle fibers into slow-twitch fibers, thereby enhancing anti-fatigue capacity and exercise endurance. While further studies are needed, incorporating GSPE into dietary supplements or functional foods could support individuals seeking to optimize their exercise performance and overall metabolic health. (© 2024 Institute of Food Technologists.) |
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| معلومات مُعتمدة: | No. 2023YFD1301302 National Key R&D Program of China; No. 32372901 National Natural Science Foundation of China; No. 2023NSFSC0238 Natural Science Foundation of Sichuan Province; No. 2021ZDZX0009 Sichuan Science and Technology Program |
| فهرسة مساهمة: | Keywords: butyric acid; grape seed proanthocyanidin extract; gut microbes; muscle fiber type transformation; skeletal muscle |
| المشرفين على المادة: | 0 (Proanthocyanidins) 0 (Grape Seed Extract) 0 (Grape Seed Proanthocyanidins) 107-92-6 (Butyric Acid) |
| تواريخ الأحداث: | Date Created: 20240419 Date Completed: 20240613 Latest Revision: 20240613 |
| رمز التحديث: | 20240614 |
| DOI: | 10.1111/1750-3841.17075 |
| PMID: | 38638069 |
| قاعدة البيانات: | MEDLINE |
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