دورية أكاديمية
Cabot rings in a cat with myeloproliferative disease.
| العنوان: | Cabot rings in a cat with myeloproliferative disease. |
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| المؤلفون: | Fujimoto M; Joint Faculty of Veterinary Medicine, Kagoshima University Veterinary Teaching Hospital, Kagoshima University, Kagoshima, Japan., Takahashi M; Joint Faculty of Veterinary Medicine, Kagoshima University Veterinary Teaching Hospital, Kagoshima University, Kagoshima, Japan., Hifumi T; Laboratory of Veterinary Histopathology, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan., Yabuki A; Joint Faculty of Veterinary Medicine, Kagoshima University Veterinary Teaching Hospital, Kagoshima University, Kagoshima, Japan., Furusawa Y; Joint Faculty of Veterinary Medicine, Kagoshima University Veterinary Teaching Hospital, Kagoshima University, Kagoshima, Japan., Hatai H; Laboratory of Veterinary Histopathology, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan.; Farm Animal Clinical Skills and Disease Control Center, Iwate University, Morikawa, Iwate, Japan., Endo Y; Laboratory of Veterinary Small Animal Internal Medicine, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan. |
| المصدر: | Veterinary clinical pathology [Vet Clin Pathol] 2024 Jun; Vol. 53 (2), pp. 196-201. Date of Electronic Publication: 2024 Apr 19. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society for Veterinary Clinical Pathology Country of Publication: United States NLM ID: 9880575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1939-165X (Electronic) Linking ISSN: 02756382 NLM ISO Abbreviation: Vet Clin Pathol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1998- : Baton Rouge, LA : American Society for Veterinary Clinical Pathology Original Publication: 1977-<1989> : Columbia, MO : Veterinary Practice Pub. Co. |
| مواضيع طبية MeSH: | Cat Diseases*/pathology , Cat Diseases*/diagnosis , Myeloproliferative Disorders*/veterinary , Myeloproliferative Disorders*/pathology , Myeloproliferative Disorders*/complications, Cats ; Female ; Animals ; Fatal Outcome ; Erythrocytes, Abnormal/pathology ; Anemia/veterinary ; Anemia/pathology ; Erythrocytes/pathology |
| مستخلص: | A 6-year-old spayed female Scottish Fold cat presented with lethargy and anorexia. A complete blood cell count indicated severe anemia and mild thrombocytopenia. Examination of peripheral blood smears revealed marked changes in the erythroid lineage, including the presence of basophilic stippling and Howell-Jolly bodies as well as an increase in nucleated erythrocytes, polychromatophils, ovalocytes, and schistocytes. Additionally, some erythrocytes contained a ring or figure-eight shaped structure known as a Cabot ring, which were especially observed in polychromatophilic erythrocytes. Hemolytic diseases (Mycoplasma infection and IMHA) were diagnostically excluded, and the cat was treated through prednisolone administration, whole blood transfusion, and administration of vitamins (K2 and B12); however, the anemia progressively worsened. Cabot rings were observed until Day 22 and subsequently disappeared as the number of nucleated RBCs increased, and the erythrocyte lineage shifted to immature population. On Day 42, peripheral blood examination revealed further left shifting and appearance of many rubriblasts. The patient died at home on Day 43. Necropsy revealed neoplastic cells infiltrating the bone marrow and other organs, which were immunopositive to CD71 which is an erythroid lineage marker. In humans, Cabot rings have been observed in megaloblastic anemia, lead poisoning, myelodysplastic syndrome, and myelofibrosis; further, they are thought to be related to stressed bone marrow and dyserythropoiesis. This is the first case report of a cat with Cabot rings, which are suggestive of defects in erythroid lineage production. (© 2024 American Society for Veterinary Clinical Pathology.) |
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| فهرسة مساهمة: | Keywords: CD71 antigen; anemia; blood; dyserythropoiesis; erythrocyte inclusions; feline |
| تواريخ الأحداث: | Date Created: 20240419 Date Completed: 20240616 Latest Revision: 20240616 |
| رمز التحديث: | 20240617 |
| DOI: | 10.1111/vcp.13340 |
| PMID: | 38641552 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1939-165X |
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| DOI: | 10.1111/vcp.13340 |