دورية أكاديمية
Exploring Raloxifene-Based Metallodrugs: A Versatile Vector Combined with Platinum(II), Palladium(II) and Nickel(II) Dichlorides and Carborates against Triple-Negative Breast Cancer.
| العنوان: | Exploring Raloxifene-Based Metallodrugs: A Versatile Vector Combined with Platinum(II), Palladium(II) and Nickel(II) Dichlorides and Carborates against Triple-Negative Breast Cancer. |
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| المؤلفون: | Kazimir A; new address, Institute for Drug Discovery, Leipzig University, Leipzig, Brüderstraße 34, 04103, Germany.; Faculty of Chemistry and Mineralogy, Leipzig University, Johannisallee 29, Leipzig, 04103, Germany., Götze T; Faculty of Chemistry and Mineralogy, Leipzig University, Johannisallee 29, Leipzig, 04103, Germany., Lönnecke P; Faculty of Chemistry and Mineralogy, Leipzig University, Johannisallee 29, Leipzig, 04103, Germany., Murganić B; Institute of Nuclear Sciences 'Vinča', University of Belgrade, 12-14 Mike Petrovića Street, Belgrade, 11351, Serbia., Mijatović S; Department of Immunology, Institute for Biological Research 'Siniša Stanković', National Institute of Republic of Serbia, Belgrade University, Bul. despota Stefana 142, Belgrade, 11060, Serbia., Maksimović-Ivanić D; Department of Immunology, Institute for Biological Research 'Siniša Stanković', National Institute of Republic of Serbia, Belgrade University, Bul. despota Stefana 142, Belgrade, 11060, Serbia., Hey-Hawkins E; Faculty of Chemistry and Mineralogy, Leipzig University, Johannisallee 29, Leipzig, 04103, Germany. |
| المصدر: | ChemMedChem [ChemMedChem] 2024 Jul 15; Vol. 19 (14), pp. e202400006. Date of Electronic Publication: 2024 Jun 05. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Weinheim, Germany : Wiley-VCH, c2006- |
| مواضيع طبية MeSH: | Palladium*/chemistry , Palladium*/pharmacology , Nickel*/chemistry , Nickel*/pharmacology , Triple Negative Breast Neoplasms*/drug therapy , Triple Negative Breast Neoplasms*/pathology , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Platinum*/chemistry , Platinum*/pharmacology , Coordination Complexes*/chemistry , Coordination Complexes*/pharmacology , Coordination Complexes*/chemical synthesis , Cell Proliferation*/drug effects , Raloxifene Hydrochloride*/chemistry , Raloxifene Hydrochloride*/pharmacology , Drug Screening Assays, Antitumor*, Humans ; Cell Line, Tumor ; Structure-Activity Relationship ; Molecular Structure ; Dose-Response Relationship, Drug ; Female |
| مستخلص: | Triple-negative breast cancer (TNBC) poses challenges in therapy due to the absence of target expression such as estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). Frequently, the treatment of TNBC involves the combination of several therapeutics. However, an enhanced therapeutic effect can be also achieved within a single molecule. The efficacy of raloxifene can be improved by designing a raloxifene-based hybrid drug bearing a 2,2'-bipyridine moiety (2). Integration of platinum(II), palladium(II), and nickel(II) complexes into this structure dramatically changed the cytotoxicity. The platinum(II) dichloride complex 3 did not demonstrate any activity, while palladium(II) and nickel(II) dichloride complexes 4 and 5 exhibited various cytotoxic behavior towards different types of hormone-receptor positive (HR+) cancer and TNBC cell lines. The replacement of the two chlorido ligands in 3-5 with a dicarbollide (carborate) ion [C (© 2024 The Authors. ChemMedChem published by Wiley-VCH GmbH.) |
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| معلومات مُعتمدة: | 451-03-66/2024-03/200007 Ministry of Science, Technological Development and Innovation of the Republic of Serbia; 57440919 DAAD; Research Grants Bi-national; Projekt DEAL |
| فهرسة مساهمة: | Keywords: TNBC; metallacarborane; metallodrugs; nickel; palladium; platinum; raloxifene; senescence |
| المشرفين على المادة: | 5TWQ1V240M (Palladium) 7OV03QG267 (Nickel) 0 (Antineoplastic Agents) 49DFR088MY (Platinum) 0 (Coordination Complexes) 4F86W47BR6 (Raloxifene Hydrochloride) |
| تواريخ الأحداث: | Date Created: 20240420 Date Completed: 20240715 Latest Revision: 20240715 |
| رمز التحديث: | 20240715 |
| DOI: | 10.1002/cmdc.202400006 |
| PMID: | 38642018 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1860-7187 |
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| DOI: | 10.1002/cmdc.202400006 |