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Comparative transcriptome and metabolite profiling reveal diverse pattern of CYP-TS gene expression during corosolic acid biosynthesis in Lagerstroemia speciosa (L.) Pers.

التفاصيل البيبلوغرافية
العنوان: Comparative transcriptome and metabolite profiling reveal diverse pattern of CYP-TS gene expression during corosolic acid biosynthesis in Lagerstroemia speciosa (L.) Pers.
المؤلفون: Surendran K; Department of Genomic Science, Central University of Kerala, Kasaragod, 671320, India., Pradeep S; Department of Genomic Science, Central University of Kerala, Kasaragod, 671320, India., Pillai PP; Department of Genomic Science, Central University of Kerala, Kasaragod, 671320, India. padmeshpillai@gmail.com.
المصدر: Plant cell reports [Plant Cell Rep] 2024 Apr 20; Vol. 43 (5), pp. 122. Date of Electronic Publication: 2024 Apr 20.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: Germany NLM ID: 9880970 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-203X (Electronic) Linking ISSN: 07217714 NLM ISO Abbreviation: Plant Cell Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Berlin ; New York : Springer, 1981-
مواضيع طبية MeSH: Transcriptome*/genetics , Lagerstroemia*/genetics , Lagerstroemia*/metabolism , Triterpenes*, Cytochrome P-450 Enzyme System/genetics ; Cytochrome P-450 Enzyme System/metabolism ; Gene Expression Profiling
مستخلص: Key Message: Extensive leaf transcriptome profiling and differential gene expression analysis of field grown and elicited shoot cultures of L. speciosa suggest that differential synthesis of CRA is mediated primarily by CYP and TS genes, showing functional diversity. Lagerstroemia speciosa L. is a tree species with medicinal and horticultural attributes. The pentacyclic triterpene, Corosolic acid (CRA) obtained from this species is widely used for the management of diabetes mellitus in traditional medicine. The high mercantile value of the compound and limited availability of innate resources entail exploration of alternative sources for CRA production. Metabolic pathway engineering for enhanced bioproduction of plant secondary metabolites is an attractive proposition for which, candidate genes in the pathway need to be identified and characterized. Therefore, in the present investigation, we focused on the identification of cytochrome P450 (CYP450) and oxidosqualene cyclases (OSC) genes and their differential expression during biosynthesis of CRA. The pattern of differential expression of these genes in the shoot cultures of L. speciosa, elicited with different epigenetic modifiers (azacytidine (AzaC), sodium butyrate (NaBu) and anacardic acid (AA)), was studied in comparison with field grown plant. Further, in vitro cultures with varying (low to high) concentrations of CRA were systematically assessed for the expression of CYP-TS and associated genes involved in CRA biosynthesis by transcriptome sequencing. The sequenced samples were de novo assembled into 180,290 transcripts of which, 92,983 transcripts were further annotated by UniProt. The results are collectively given in co-occurrence heat maps to identify the differentially expressed genes. The combined transcript and metabolite profiles along with RT-qPCR analysis resulted in the identification of CYP-TS genes with high sequence variation. Further, instances of concordant/discordant relation between CRA biosynthesis and CYP-TS gene expression were observed, indicating functional diversity in genes.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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فهرسة مساهمة: Keywords: Lagerstroemia speciosa L.; Anacardic acid; Azacytidine; Corosolic acid; Sodium butyrate
المشرفين على المادة: AMX2I57A98 (corosolic acid)
9035-51-2 (Cytochrome P-450 Enzyme System)
0 (Triterpenes)
تواريخ الأحداث: Date Created: 20240420 Date Completed: 20240422 Latest Revision: 20240509
رمز التحديث: 20240510
DOI: 10.1007/s00299-024-03203-0
PMID: 38642121
قاعدة البيانات: MEDLINE
الوصف
تدمد:1432-203X
DOI:10.1007/s00299-024-03203-0