دورية أكاديمية
أعرض في EDS

Meta-analysis of SATB2 immunohistochemical expression in colorectal cancer versus primary ovarian mucinous neoplasms.

التفاصيل البيبلوغرافية
العنوان: Meta-analysis of SATB2 immunohistochemical expression in colorectal cancer versus primary ovarian mucinous neoplasms.
المؤلفون: Maguire B; Department of Colorectal Surgery, Beaumont Hospital, Dublin 9, Ireland; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland; Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin 2, Ireland., Duggan WP; Department of Colorectal Surgery, Beaumont Hospital, Dublin 9, Ireland; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland., Prehn JHM; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland; Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin 2, Ireland., Burke JP; Department of Colorectal Surgery, Beaumont Hospital, Dublin 9, Ireland. Electronic address: johnburke@rcsi.com.
المصدر: Annals of diagnostic pathology [Ann Diagn Pathol] 2024 Aug; Vol. 71, pp. 152302. Date of Electronic Publication: 2024 Apr 16.
نوع المنشور: Journal Article; Meta-Analysis; Review
اللغة: English
بيانات الدورية: Publisher: W.B. Saunders Co Country of Publication: United States NLM ID: 9800503 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-8198 (Electronic) Linking ISSN: 10929134 NLM ISO Abbreviation: Ann Diagn Pathol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Philadelphia, PA : W.B. Saunders Co., c1997-
مواضيع طبية MeSH: Matrix Attachment Region Binding Proteins*/metabolism , Colorectal Neoplasms*/pathology , Colorectal Neoplasms*/metabolism , Colorectal Neoplasms*/diagnosis , Ovarian Neoplasms*/metabolism , Ovarian Neoplasms*/pathology , Ovarian Neoplasms*/diagnosis , Immunohistochemistry*/methods , Biomarkers, Tumor*/metabolism , Biomarkers, Tumor*/analysis , Transcription Factors*/metabolism , Adenocarcinoma, Mucinous*/metabolism , Adenocarcinoma, Mucinous*/pathology , Adenocarcinoma, Mucinous*/diagnosis, Humans ; Female ; Diagnosis, Differential
مستخلص: Background: Reliably distinguishing primary ovarian mucinous neoplasms (POMNs) from metastatic colorectal cancers (CRCs) is both challenging to the histopathologist and of great clinical importance. Special AT-rich sequence binding protein-2 (SATB2) has emerged as a useful diagnostic immunohistochemical marker of colorectal cancer. This meta-analysis compares SATB2 expression in POMNs and CRC.
Methods: A systematic literature search for relevant studies was conducted. Meta-analysis of SATB2 positivity was undertaken using a random effects model.
Results: Seven studies including 711 CRCs and 528 POMNs were included. SATB2 positivity was seen in 81 % (95 % CI: 72-88 %) of CRCs and 4 % (95 % CI: 1-11 %) of POMNs. Variation was seen in immunohistochemical methods used for SATB2 detection and threshold for positivity.
Conclusion: SATB2 staining remains high in CRC and low in POMNs, supporting its use in differentiating these two pathologies with vastly differing prognosis and treatment.
Competing Interests: Declaration of competing interest There are no conflicts of interest.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: Colorectal cancer; Immunohistochemistry; Primary ovarian mucinous neoplasms; SATB2
المشرفين على المادة: 0 (Matrix Attachment Region Binding Proteins)
0 (SATB2 protein, human)
0 (Biomarkers, Tumor)
0 (Transcription Factors)
تواريخ الأحداث: Date Created: 20240420 Date Completed: 20240607 Latest Revision: 20240607
رمز التحديث: 20240610
DOI: 10.1016/j.anndiagpath.2024.152302
PMID: 38642469
قاعدة البيانات: MEDLINE
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