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The functional connectivity of the right superior temporal gyrus is associated with psychological risk and resilience factors for suicidality.

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العنوان: The functional connectivity of the right superior temporal gyrus is associated with psychological risk and resilience factors for suicidality.
المؤلفون: Cattarinussi G; Department of Neuroscience, University of Padova, Padua, Italy; Padova Neuroscience Center, University of Padova, Padua, Italy., Meda N; Department of Neuroscience, University of Padova, Padua, Italy; Padova University Hospital, Padua, Italy., Miola A; Department of Neuroscience, University of Padova, Padua, Italy; Padova Neuroscience Center, University of Padova, Padua, Italy; Casa di Cura Parco dei Tigli, Padova, Italy., Sambataro F; Department of Neuroscience, University of Padova, Padua, Italy; Padova Neuroscience Center, University of Padova, Padua, Italy; Padova University Hospital, Padua, Italy. Electronic address: fabio.sambataro@unipd.it.
المصدر: Journal of affective disorders [J Affect Disord] 2024 Jul 15; Vol. 357, pp. 51-59. Date of Electronic Publication: 2024 Apr 21.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7906073 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2517 (Electronic) Linking ISSN: 01650327 NLM ISO Abbreviation: J Affect Disord Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press.
مواضيع طبية MeSH: Magnetic Resonance Imaging* , Temporal Lobe*/diagnostic imaging , Temporal Lobe*/physiopathology , Resilience, Psychological* , Connectome* , Loneliness*/psychology, Humans ; Male ; Female ; Young Adult ; Adult ; Cross-Sectional Studies ; Risk Factors ; Suicide, Attempted/psychology ; Suicide, Attempted/statistics & numerical data ; Suicidal Ideation
مستخلص: Introduction: Suicide attempters show increased activation in the right superior temporal gyrus (rSTG). Here, we investigated the rSTG functional connectivity (FC) to identify a functional network involved in suicidality and its associations with psychological suicidality risk and resilience factors.
Methods: The resting state functional magnetic resonance imaging data of 151 healthy individuals from the Human Connectome Project Young Adult database were used to explore the FC of the rSTG with itself and with the rest of the brain. The correlation between the rSTG FC and loneliness and purpose in life scores was assessed with the NIH Toolbox. The effect of sex was also investigated.
Results: The rSTG had a positive FC with bilateral cortical and subcortical regions, including frontal, temporal, parietal, occipital, limbic, and cerebellar regions, and a negative FC with the medulla oblongata. The FC of the rSTG with itself and with the left central operculum were associated with loneliness scores. The within rSTG FC was also negatively correlated with purpose in life scores, although at a trend level. We did not find any effect of sex on FC and its associations with psychological factors.
Limitations: The cross-sectional design, the limited age range, and the lack of measures of suicidality limit the generalizability of our findings.
Conclusions: The rSTG functional network is associated with loneliness and purpose in life. Together with the existing literature on suicide, this supports the idea that the neural activity of rSTG may contribute to suicidality by modulating risk and resilience factors associated with suicidality.
Competing Interests: Declaration of competing interest None.
(Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Loneliness; Meaning in life; Seed-based functional connectivity; Suicide risk; fMRI
تواريخ الأحداث: Date Created: 20240423 Date Completed: 20240513 Latest Revision: 20240513
رمز التحديث: 20240514
DOI: 10.1016/j.jad.2024.04.048
PMID: 38653349
قاعدة البيانات: MEDLINE
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