دورية أكاديمية
Skeletal consequences of preterm birth in pigs as a model for preterm infants.
| العنوان: | Skeletal consequences of preterm birth in pigs as a model for preterm infants. |
|---|---|
| المؤلفون: | Wilson BM; Department of Anatomy & Cell Biology, Rush University Medical Center, Chicago, IL, 60612, United States., Ko FC; Department of Anatomy & Cell Biology, Rush University Medical Center, Chicago, IL, 60612, United States.; Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL, 60612, United States., Moran MM; Department of Anatomy & Cell Biology, Rush University Medical Center, Chicago, IL, 60612, United States.; Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL, 60612, United States., Adra A; Department of Anatomy & Cell Biology, Rush University Medical Center, Chicago, IL, 60612, United States., Rasmussen MB; Comparative Pediatrics and Nutrition, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, DK-1958, Denmark., Thymann T; Comparative Pediatrics and Nutrition, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, DK-1958, Denmark., Sangild PT; Comparative Pediatrics and Nutrition, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, DK-1958, Denmark.; Department of Neonatology, Rigshospitalet, Copenhagen, DK-2100, Denmark.; Department of Pediatrics, Odense University Hospital, Odense, DK-5000, Denmark.; Faculty of Theology, University of Copenhagen, Copenhagen, DK-2300, Denmark., Sumner DR; Department of Anatomy & Cell Biology, Rush University Medical Center, Chicago, IL, 60612, United States.; Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL, 60612, United States. |
| المصدر: | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research [J Bone Miner Res] 2024 Jul 23; Vol. 39 (6), pp. 791-803. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society for Bone and Mineral Research Country of Publication: England NLM ID: 8610640 Publication Model: Print Cited Medium: Internet ISSN: 1523-4681 (Electronic) Linking ISSN: 08840431 NLM ISO Abbreviation: J Bone Miner Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2000- : Washington, DC : American Society for Bone and Mineral Research Original Publication: New York : Mary Ann Liebert, Inc., c1986- |
| مواضيع طبية MeSH: | Premature Birth* , Insulin-Like Growth Factor I*/metabolism , Disease Models, Animal*, Animals ; Swine ; Female ; Humans ; Bone and Bones/drug effects ; Bone and Bones/pathology ; Bone and Bones/metabolism ; Infant, Newborn ; Infant, Premature ; Animals, Newborn ; Alkaline Phosphatase/metabolism |
| مستخلص: | Preterm birth affects about 10% of all live births with many resultant health challenges, including metabolic bone disease of prematurity (MBDP), which is characterized by elevated alkaline phosphatase, suppressed phosphate, and deficient skeletal development. Because of the lack of an animal model, very little is known about bone structure, strength, and quality after preterm birth. This study investigated the utility of a pig model to replicate clinical features of preterm birth, including MBDP, and sought to determine if early postnatal administration of IGF-1 was an effective treatment. Preterm pigs, born by caesarean section at 90% gestation, were reared in intensive care facilities (respiratory, thermoregulatory, and nutritional support) and compared with sow-reared term pigs born vaginally. Preterm pigs were systemically treated with vehicle or IGF-1 (recombinant human IGF-1/BP-3, 2.25 mg/kg/d). Tissues were collected at postnatal days 1, 5, and 19 (the normal weaning period in pigs). Most bone-related outcomes were affected by preterm birth throughout the study period, whereas IGF-1 supplementation had almost no effect. By day 19, alkaline phosphatase was elevated, phosphate and calcium were reduced, and the bone resorption marker C-terminal crosslinks of type I collagen was elevated in preterm pigs compared to term pigs. Preterm pigs also had decrements in femoral cortical cross-sectional properties, consistent with reduced whole-bone strength. Thus, the preterm pig model replicates many features of preterm bone development in infants, including features of MBDP, and allows for direct interrogation of skeletal tissues, enhancing the field's ability to examine underlying mechanisms. (© The Author(s) 2024. Published by Oxford University Press on behalf of the American Society for Bone and Mineral Research. All rights reserved. For permissions, please email: journals.permissions@oup.com.) |
| معلومات مُعتمدة: | T32AR073157 United States NH NIH HHS; Takeda Pharmaceuticals; Oak Hill Bio; University of Copenhagen; Little Giraffe Foundation |
| فهرسة مساهمة: | Keywords: IGF-1; bone; metabolic bone disease of prematurity; pig model; preterm birth Local Abstract: [plain-language-summary] Premature birth interrupts a critical period of skeletal development as the majority of fetal bone mineral accumulation occurs during the last gestational trimester, leaving preterm infants at increased risk for low bone mineral density and fractures. Although there are some data on growth in bone mass in preterm infants, very little is known about bone structural properties, quality, and strength during development after preterm birth. In this study, we sought to evaluate the pig as a model for postnatal skeletal development after premature birth. Preterm pigs born after approximately 90% of the full gestation period were compared to full-term control pigs through day 19 of life. Levels of 2 blood markers used to diagnose osteoporosis of prematurity were replicated in the pig model. Bone properties related to strength were reduced even when accounting for their smaller body size, possibly suggesting elevated fracture risk in preterm infants. Based on the similarities between the preterm pig model and preterm human infants, the pig model may prove to be useful to study factors and interventions affecting postnatal bone development after preterm birth. |
| المشرفين على المادة: | 67763-96-6 (Insulin-Like Growth Factor I) EC 3.1.3.1 (Alkaline Phosphatase) |
| تواريخ الأحداث: | Date Created: 20240424 Date Completed: 20240724 Latest Revision: 20240724 |
| رمز التحديث: | 20240725 |
| DOI: | 10.1093/jbmr/zjae064 |
| PMID: | 38655758 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1523-4681 |
|---|---|
| DOI: | 10.1093/jbmr/zjae064 |