دورية أكاديمية
Estrogen receptor beta expression and role in cancers.
| العنوان: | Estrogen receptor beta expression and role in cancers. |
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| المؤلفون: | Monteiro FL; SciLifeLab, Department of Protein Science, KTH Royal Institute of Technology, Solna 171 21, Sweden; Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge 141 83, Sweden., Stepanauskaite L; SciLifeLab, Department of Protein Science, KTH Royal Institute of Technology, Solna 171 21, Sweden; Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge 141 83, Sweden., Archer A; SciLifeLab, Department of Protein Science, KTH Royal Institute of Technology, Solna 171 21, Sweden; Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge 141 83, Sweden., Williams C; SciLifeLab, Department of Protein Science, KTH Royal Institute of Technology, Solna 171 21, Sweden; Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge 141 83, Sweden. Electronic address: cecilia.williams@scilifelab.se. |
| المصدر: | The Journal of steroid biochemistry and molecular biology [J Steroid Biochem Mol Biol] 2024 Sep; Vol. 242, pp. 106526. Date of Electronic Publication: 2024 Apr 22. |
| نوع المنشور: | Journal Article; Review; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: Pergamon Country of Publication: England NLM ID: 9015483 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1220 (Electronic) Linking ISSN: 09600760 NLM ISO Abbreviation: J Steroid Biochem Mol Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford ; New York : Pergamon, c1990- |
| مواضيع طبية MeSH: | Estrogen Receptor beta*/metabolism , Estrogen Receptor beta*/genetics , Neoplasms*/metabolism , Neoplasms*/genetics, Humans ; Female ; Animals ; Male ; Gene Expression Regulation, Neoplastic ; Testicular Neoplasms/metabolism ; Testicular Neoplasms/genetics ; Testicular Neoplasms/pathology ; Granulosa Cell Tumor/metabolism ; Granulosa Cell Tumor/genetics ; Granulosa Cell Tumor/pathology ; Breast Neoplasms/metabolism ; Breast Neoplasms/genetics ; Adrenal Gland Neoplasms/genetics ; Adrenal Gland Neoplasms/metabolism ; Adrenal Gland Neoplasms/pathology ; Lymphoma/metabolism ; Lymphoma/genetics ; Lymphoma/pathology |
| مستخلص: | Estrogen drives the growth of some cancers, such as breast cancer, via estrogen receptor alpha (ERα). Estrogen also activates ERβ, but whether ERβ is expressed and has a role in different cancers is debated. The use of nonspecific antibodies has contributed to the confusion, and this review delves into ERβ's controversial role in cancer and focuses on tumor expression that can be supported by non-antibody-dependent assays. We discuss its expression at the transcript level and focus on its potential role in lymphoma, granulosa cell tumors, testicular, and adrenal cancers, emphasizing recent findings and the complexities that necessitate further research. (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
| فهرسة مساهمة: | Keywords: ESR2, isoforms; Estrogen receptor beta; cancer; expression; microenvironment |
| المشرفين على المادة: | 0 (Estrogen Receptor beta) |
| تواريخ الأحداث: | Date Created: 20240424 Date Completed: 20240614 Latest Revision: 20240819 |
| رمز التحديث: | 20240819 |
| DOI: | 10.1016/j.jsbmb.2024.106526 |
| PMID: | 38657699 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-1220 |
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| DOI: | 10.1016/j.jsbmb.2024.106526 |