دورية أكاديمية
Fetal Sex as Moderating Factor for the Relationship Between Maternal Childhood Trauma and Salivary Kynurenic Acid and Tryptophan in Pregnancy: A Pilot Study.
| العنوان: | Fetal Sex as Moderating Factor for the Relationship Between Maternal Childhood Trauma and Salivary Kynurenic Acid and Tryptophan in Pregnancy: A Pilot Study. |
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| المؤلفون: | Pedraz-Petrozzi B; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany., Lamadé EK; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany., Marszalek-Grabska M; Department of Experimental and Clinical Pharmacology, Medical University of Lublin, Poland., Trzpil A; Department of Bioanalytics, Medical University of Lublin, Poland., Lindner O; Center for Child and Adolescent Health, Pediatrics, University Hospital of Freiburg, Germany., Meininger P; Department of Gynecology and Obstetrics, Westpfalz-Klinikum, Kaiserslautern, Germany., Fornal E; Department of Bioanalytics, Medical University of Lublin, Poland., Turski WA; Department of Experimental and Clinical Pharmacology, Medical University of Lublin, Poland., Witt SH; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany., Gilles M; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany., Deuschle M; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany. |
| المصدر: | International journal of tryptophan research : IJTR [Int J Tryptophan Res] 2024 Apr 23; Vol. 17, pp. 11786469241244603. Date of Electronic Publication: 2024 Apr 23 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: SAGE Publications Country of Publication: United States NLM ID: 101513378 Publication Model: eCollection Cited Medium: Print ISSN: 1178-6469 (Print) Linking ISSN: 11786469 NLM ISO Abbreviation: Int J Tryptophan Res Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: <2016- > : Thousand Oaks, CA : SAGE Publications Original Publication: Auckland, NZ : Libertas Academica |
| مستخلص: | Traumatic experiences and fetal development influence tryptophan (TRP) and its neuroactive byproduct, kynurenic acid (KYNA). Maternal TRP metabolite levels during pregnancy vary by fetal sex, with higher concentrations in mothers carrying male fetuses. This pilot study aimed to explore the relationship between offspring sex, maternal childhood trauma, and maternal salivary KYNA and TRP levels during pregnancy. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) was used to determine KYNA and TRP levels in maternal saliva samples collected from 35 late-pregnancy participants. Maternal childhood trauma was assessed using the Childhood Trauma Questionnaire, including subscales for emotional abuse, physical abuse, sexual abuse, emotional neglect, and physical neglect. Among mothers pregnant with boys, salivary KYNA significantly correlated with physical and emotional neglect, and salivary TRP with emotional neglect. No significant correlations were found in mothers who delivered female offspring. Significant associations of childhood trauma and offspring sex were found for salivary KYNA but not TRP concentrations. Mothers with higher trauma levels who delivered boys exhibited higher levels of salivary KYNA compared to those with lower trauma levels. Moreover, mothers with higher trauma levels who delivered boys had higher salivary KYNA levels than those with higher trauma levels who delivered girls. This pilot study provides evidence of an association between maternal childhood trauma and TRP metabolism, measured in saliva, especially in mothers pregnant with boys. However, longitudinal studies with larger sample sizes are required to confirm these results. Competing Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. (© The Author(s) 2024.) |
| References: | Brain Behav Immun. 2019 Mar;77:77-91. (PMID: 30578932) J Affect Disord. 2019 Aug 1;255:168-176. (PMID: 31158779) Psychiatry Res. 2013 Feb 28;211(2):93-103. (PMID: 23154098) Front Immunol. 2022 Sep 23;13:1004545. (PMID: 36211365) Cells. 2023 Sep 06;12(18):. (PMID: 37759447) Sci Rep. 2023 Aug 2;13(1):12554. (PMID: 37532780) Int Rev Psychiatry. 2015;27(3):180-96. (PMID: 26100613) BMC Neurosci. 2022 Nov 10;23(1):62. (PMID: 36357867) Gend Med. 2007 Mar;4(1):19-30. (PMID: 17584623) Int J Environ Res Public Health. 2023 Feb 08;20(4):. (PMID: 36833633) Anal Chem. 2020 Apr 7;92(7):5116-5124. (PMID: 32150679) Psychother Psychosom Med Psychol. 2012 Feb;62(2):47-51. (PMID: 22203470) Am J Reprod Immunol. 2015 Mar;73(3):251-62. (PMID: 25091957) Front Hum Neurosci. 2021 Apr 29;15:636144. (PMID: 33994977) Trauma Violence Abuse. 2021 Dec;22(5):1181-1191. (PMID: 32207395) Sci Rep. 2022 Nov 15;12(1):19619. (PMID: 36380091) Early Hum Dev. 2009 May;85(5):319-24. (PMID: 19162414) Cytokine. 2020 Dec;136:155290. (PMID: 32956948) Br J Psychiatry. 2017 Sep;211(3):144-150. (PMID: 28729357) Dev Neurosci. 2022;44(6):603-614. (PMID: 36162387) Neuropsychopharmacology. 2018 Jul;43(8):1706-1711. (PMID: 29728648) Psychoneuroendocrinology. 2011 May;36(4):588-91. (PMID: 20940089) Brain Behav Immun. 2020 Oct;89:175-183. (PMID: 32531426) J Chromatogr. 1979 Feb 21;162(2):153-61. (PMID: 762217) Brain Res Bull. 2000 Jun;52(3):197-205. (PMID: 10822161) Schizophr Res. 2017 Jul;185:200-201. (PMID: 28082139) Dev Neurosci. 2016;38(6):458-468. (PMID: 28214871) JAMA Psychiatry. 2014 Jul 1;71(7):761-8. (PMID: 24806441) J Neuroinflammation. 2020 Feb 15;17(1):56. (PMID: 32061259) BMC Pregnancy Childbirth. 2022 Jan 4;22(1):10. (PMID: 34983417) Brain Behav Immun. 2016 May;54:59-72. (PMID: 26724575) Biol Res Nurs. 2018 May;20(3):284-291. (PMID: 29141444) J Affect Disord. 2005 Jun;86(2-3):135-42. (PMID: 15935232) Dev Psychobiol. 2020 Mar;62(2):154-169. (PMID: 31372993) Prog Neuropsychopharmacol Biol Psychiatry. 2016 Feb 4;65:104-17. (PMID: 26382758) Transl Psychiatry. 2022 Aug 4;12(1):313. (PMID: 35927237) J Eval Clin Pract. 2004 May;10(2):307-12. (PMID: 15189396) Mol Autism. 2020 Jan 16;11(1):7. (PMID: 32131900) Int J Mol Sci. 2021 Feb 14;22(4):. (PMID: 33672958) Behav Res Methods. 2007 May;39(2):175-91. (PMID: 17695343) Sci Rep. 2022 Apr 19;12(1):6464. (PMID: 35440600) Toxins (Basel). 2023 Feb 13;15(2):. (PMID: 36828466) Transl Psychiatry. 2019 Jan 29;9(1):37. (PMID: 30696814) J Psychiatry Neurosci. 2012 Jan;37(1):37-45. (PMID: 22008179) J Allergy Clin Immunol. 2016 Sep;138(3):740-747.e3. (PMID: 26953156) Psychopharmacology (Berl). 2020 Jul;237(7):1931-1941. (PMID: 32215686) Diabetes Care. 2015 May;38(5):844-51. (PMID: 25693837) |
| فهرسة مساهمة: | Keywords: Adverse childhood experience; fetal sex; kynurenic acid; pregnancy; tryptophan |
| تواريخ الأحداث: | Date Created: 20240425 Latest Revision: 20240426 |
| رمز التحديث: | 20240426 |
| مُعرف محوري في PubMed: | PMC11041113 |
| DOI: | 10.1177/11786469241244603 |
| PMID: | 38660592 |
| قاعدة البيانات: | MEDLINE |
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