دورية أكاديمية
أعرض في EDS

Sex-Related Disparities in Cardiovascular Outcomes Among Older Adults With Late-Onset Hypertension.

التفاصيل البيبلوغرافية
العنوان: Sex-Related Disparities in Cardiovascular Outcomes Among Older Adults With Late-Onset Hypertension.
المؤلفون: Bugeja A; Division of Nephrology, Department of Medicine (A.B., M.M.S., M.R., G.L.H., G.K.), University of Ottawa and The Ottawa Hospital, ON, Canada.; School of Epidemiology and Public Health (A.B., C.G., M.M.S., C.E.K., P.M., G.L.H., D.I.M.), University of Ottawa, ON, Canada.; Kidney Research Centre, Ottawa Hospital Research Institute (A.B., M.M.S., M.R., G.L.H., G.K.), University of Ottawa, ON, Canada.; Clinical Epidemiology Program, Ottawa Hospital Research Institute, The Ottawa Hospital, ON, Canada (A.B., C.G., M.M.S., C.E.K., P.M., M.R., G.L.H., G.K., D.I.M.)., Girard C; School of Epidemiology and Public Health (A.B., C.G., M.M.S., C.E.K., P.M., G.L.H., D.I.M.), University of Ottawa, ON, Canada.; Clinical Epidemiology Program, Ottawa Hospital Research Institute, The Ottawa Hospital, ON, Canada (A.B., C.G., M.M.S., C.E.K., P.M., M.R., G.L.H., G.K., D.I.M.).; ICES uOttawa, ON, Canada (C.G., C.E.K., G.L.H., D.I.M.)., Sood MM; Division of Nephrology, Department of Medicine (A.B., M.M.S., M.R., G.L.H., G.K.), University of Ottawa and The Ottawa Hospital, ON, Canada.; School of Epidemiology and Public Health (A.B., C.G., M.M.S., C.E.K., P.M., G.L.H., D.I.M.), University of Ottawa, ON, Canada.; Kidney Research Centre, Ottawa Hospital Research Institute (A.B., M.M.S., M.R., G.L.H., G.K.), University of Ottawa, ON, Canada.; Clinical Epidemiology Program, Ottawa Hospital Research Institute, The Ottawa Hospital, ON, Canada (A.B., C.G., M.M.S., C.E.K., P.M., M.R., G.L.H., G.K., D.I.M.)., Kendall CE; School of Epidemiology and Public Health (A.B., C.G., M.M.S., C.E.K., P.M., G.L.H., D.I.M.), University of Ottawa, ON, Canada.; Department of Family Medicine (C.E.K.), University of Ottawa, ON, Canada.; Clinical Epidemiology Program, Ottawa Hospital Research Institute, The Ottawa Hospital, ON, Canada (A.B., C.G., M.M.S., C.E.K., P.M., M.R., G.L.H., G.K., D.I.M.).; ICES uOttawa, ON, Canada (C.G., C.E.K., G.L.H., D.I.M.)., Sweet A; Faculty of Medicine (A.S., R.S.), University of Ottawa, ON, Canada., Singla R; Faculty of Medicine (A.S., R.S.), University of Ottawa, ON, Canada., Motazedian P; School of Epidemiology and Public Health (A.B., C.G., M.M.S., C.E.K., P.M., G.L.H., D.I.M.), University of Ottawa, ON, Canada.; Clinical Epidemiology Program, Ottawa Hospital Research Institute, The Ottawa Hospital, ON, Canada (A.B., C.G., M.M.S., C.E.K., P.M., M.R., G.L.H., G.K., D.I.M.).; University of Ottawa Heart Institute, ON, Canada (P.M.)., Vinson AJ; Division of Nephrology, Department of Medicine, Dalhousie University (A.J.V.).; Kidney Research Institute Nova Scotia (A.J.V.)., Ruzicka M; Division of Nephrology, Department of Medicine (A.B., M.M.S., M.R., G.L.H., G.K.), University of Ottawa and The Ottawa Hospital, ON, Canada.; Kidney Research Centre, Ottawa Hospital Research Institute (A.B., M.M.S., M.R., G.L.H., G.K.), University of Ottawa, ON, Canada.; Clinical Epidemiology Program, Ottawa Hospital Research Institute, The Ottawa Hospital, ON, Canada (A.B., C.G., M.M.S., C.E.K., P.M., M.R., G.L.H., G.K., D.I.M.)., Hundemer GL; Division of Nephrology, Department of Medicine (A.B., M.M.S., M.R., G.L.H., G.K.), University of Ottawa and The Ottawa Hospital, ON, Canada.; School of Epidemiology and Public Health (A.B., C.G., M.M.S., C.E.K., P.M., G.L.H., D.I.M.), University of Ottawa, ON, Canada.; Kidney Research Centre, Ottawa Hospital Research Institute (A.B., M.M.S., M.R., G.L.H., G.K.), University of Ottawa, ON, Canada.; Clinical Epidemiology Program, Ottawa Hospital Research Institute, The Ottawa Hospital, ON, Canada (A.B., C.G., M.M.S., C.E.K., P.M., M.R., G.L.H., G.K., D.I.M.).; ICES uOttawa, ON, Canada (C.G., C.E.K., G.L.H., D.I.M.)., Knoll G; Division of Nephrology, Department of Medicine (A.B., M.M.S., M.R., G.L.H., G.K.), University of Ottawa and The Ottawa Hospital, ON, Canada.; Kidney Research Centre, Ottawa Hospital Research Institute (A.B., M.M.S., M.R., G.L.H., G.K.), University of Ottawa, ON, Canada.; Clinical Epidemiology Program, Ottawa Hospital Research Institute, The Ottawa Hospital, ON, Canada (A.B., C.G., M.M.S., C.E.K., P.M., M.R., G.L.H., G.K., D.I.M.)., McIsaac DI; Departments of Anesthesiology and Pain Medicine (D.I.M.), University of Ottawa and The Ottawa Hospital, ON, Canada.; School of Epidemiology and Public Health (A.B., C.G., M.M.S., C.E.K., P.M., G.L.H., D.I.M.), University of Ottawa, ON, Canada.; Clinical Epidemiology Program, Ottawa Hospital Research Institute, The Ottawa Hospital, ON, Canada (A.B., C.G., M.M.S., C.E.K., P.M., M.R., G.L.H., G.K., D.I.M.).; ICES uOttawa, ON, Canada (C.G., C.E.K., G.L.H., D.I.M.).
المصدر: Hypertension (Dallas, Tex. : 1979) [Hypertension] 2024 Jul; Vol. 81 (7), pp. 1583-1591. Date of Electronic Publication: 2024 Apr 25.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Lippincott, Williams & Wilkins Country of Publication: United States NLM ID: 7906255 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4563 (Electronic) Linking ISSN: 0194911X NLM ISO Abbreviation: Hypertension Subsets: MEDLINE
أسماء مطبوعة: Publication: : Hagerstown, MD : Lippincott, Williams & Wilkins
Original Publication: [Dallas, Tex.] : [American Heart Association], [©1979]-
مواضيع طبية MeSH: Hypertension*/epidemiology, Humans ; Male ; Female ; Aged ; Ontario/epidemiology ; Incidence ; Sex Factors ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/mortality ; Cardiovascular Diseases/diagnosis ; Aged, 80 and over ; Cause of Death/trends ; Cohort Studies ; Proportional Hazards Models ; Myocardial Infarction/epidemiology ; Myocardial Infarction/mortality ; Myocardial Infarction/diagnosis ; Stroke/epidemiology ; Stroke/mortality ; Risk Factors ; Follow-Up Studies ; Age of Onset ; Heart Failure/epidemiology ; Heart Failure/mortality
مستخلص: Background: It is unclear whether sex-based differences in cardiovascular outcomes exist in late-onset hypertension.
Methods: This is a population-based cohort study in Ontario, Canada of 266 273 adults, aged ≥66 years with newly diagnosed hypertension. We determined the incidence of the primary composite cardiovascular outcome (myocardial infarction, stroke, and congestive heart failure), all-cause mortality, and cardiovascular death by sex using Cox proportional hazard models adjusted for demographic factors and comorbidities.
Results: The mean age of the total cohort was 74 years, and 135 531 (51%) were female. Over a median follow-up of 6.6 (4.7-9.0) years, females experienced a lower crude incidence rate (per 1000 person-years) than males for the primary composite cardiovascular outcome (287.3 versus 311.7), death (238.4 versus 251.4), and cardiovascular death (395.7 versus 439.6), P <0.001. The risk of primary composite cardiovascular outcome was lower among females (adjusted hazard ratio, 0.75 [95% CI, 0.73-0.76]; P <0.001) than in males. This was consistent after adjusting for the competing risk of all-cause death with a subdistributional hazard ratio, 0.88 ([95% CI, 0.86-0.91]; P <0.001).
Conclusions: Females had a lower risk of cardiovascular outcomes compared with males within a population characterized by advanced age and new hypertension. Our results highlight that the severity of outcomes is influenced by sex in relation to the age at which hypertension is diagnosed. Further studies are required to identify sex-specific variations in the diagnosis and management of late-onset hypertension due to its high incidence in this group.
Competing Interests: Disclosures A.J. Vinson has accepted consultancy funding from Paladin Labs, Inc, and Takeda Pharmaceuticals. The other authors report no conflicts.
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فهرسة مساهمة: Keywords: aged; cardiovascular diseases, epidemiology; female; hypertension, epidemiology; incident; survival analysis
تواريخ الأحداث: Date Created: 20240425 Date Completed: 20240612 Latest Revision: 20240616
رمز التحديث: 20240616
مُعرف محوري في PubMed: PMC11177607
DOI: 10.1161/HYPERTENSIONAHA.124.22870
PMID: 38660798
قاعدة البيانات: MEDLINE
الوصف
تدمد:1524-4563
DOI:10.1161/HYPERTENSIONAHA.124.22870