دورية أكاديمية
Early differential diagnosis of pancytopenia related diseases based on serum surface-enhanced Raman spectroscopy.
| العنوان: | Early differential diagnosis of pancytopenia related diseases based on serum surface-enhanced Raman spectroscopy. |
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| المؤلفون: | Chen Z; College of Medicine and Biological Information Engineering, Northeastern University, Shenyang 110169, Liaoning, China., Li Y; Department of Hematology, Shengjing Hospital of China Medical University, Shenyang 110022, China., Zhu R; College of Medicine and Biological Information Engineering, Northeastern University, Shenyang 110169, Liaoning, China., Zhou Z; School of Innovation and Entrepreneurship, Liaoning Institute of Science and Technology, Benxi 117004, China., Yan Z; Department of Urology, The First Affiliated Hospital of Ningbo University, Ningbo 315010, China., Chen S; College of Medicine and Biological Information Engineering, Northeastern University, Shenyang 110169, Liaoning, China; Foshan Graduate School of Innovation, Northeastern University, Foshan 528311, China; Key Laboratory of Intelligent Computing in Medical Image, Ministry of Education, Shenyang 110169, China. Electronic address: chenshuo@bmie.neu.edu.cn., Zhang G; Department of Hematology, Shengjing Hospital of China Medical University, Shenyang 110022, China. Electronic address: zhangguojun2020@sina.com. |
| المصدر: | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy [Spectrochim Acta A Mol Biomol Spectrosc] 2024 Aug 05; Vol. 316, pp. 124335. Date of Electronic Publication: 2024 Apr 23. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 9602533 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3557 (Electronic) Linking ISSN: 13861425 NLM ISO Abbreviation: Spectrochim Acta A Mol Biomol Spectrosc Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Original Publication: [Kidlington, Oxford, U.K. ; Tarrytown, NY] : Pergamon, c1994- |
| مواضيع طبية MeSH: | Spectrum Analysis, Raman*/methods , Pancytopenia*/diagnosis , Pancytopenia*/blood, Humans ; Diagnosis, Differential ; Discriminant Analysis ; Myelodysplastic Syndromes/diagnosis ; Myelodysplastic Syndromes/blood ; Female ; Least-Squares Analysis ; Middle Aged ; Male ; Early Diagnosis ; Adult ; Anemia, Aplastic/diagnosis ; Anemia, Aplastic/blood ; Aged |
| مستخلص: | Pancytopenia is a common blood disorder defined as the decrease of red blood cells, white blood cells and platelets in the peripheral blood. Its genesis mechanism is typically complex and a variety of diseases have been found to be capable of causing pancytopenia, some of which are featured by their high mortality rates. Early judgement on the cause of pancytopenia can benefit timely and appropriate treatment to improve patient survival significantly. In this study, a serum surface-enhanced Raman spectroscopy (SERS) method was explored for the early differential diagnosis of three pancytopenia related diseases, i.e., aplastic anemia (AA), myelodysplastic syndrome (MDS) and spontaneous remission of pancytopenia (SRP), in which the patients with those pancytopenia related diseases at initial stage exhibited same pancytopenia symptom but cannot be conclusively diagnosed through conventional clinical examinations. The SERS spectral analysis results suggested that certain amino acids, protein substances and nucleic acids are expected to be potential biomarkers for their early differential diagnosis. In addition, a diagnostic model was established based on the joint use of partial least squares analysis and linear discriminant analysis (PLS-LDA), and an overall accuracy of 86.67 % was achieved to differentiate those pancytopenia related diseases, even at the time that confirmed diagnosis cannot be made by routine clinical examinations. Therefore, the proposed method has demonstrated great potential for the early differential diagnosis of pancytopenia related diseases, thus it has significant clinical importance for the timely and rational guidance on subsequent treatment to improve patient survival. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Biochemical analysis; Blood serum; PLS-LDA; Pancytopenia related diseases; Surface-enhanced Raman spectroscopy |
| تواريخ الأحداث: | Date Created: 20240425 Date Completed: 20240513 Latest Revision: 20240513 |
| رمز التحديث: | 20240514 |
| DOI: | 10.1016/j.saa.2024.124335 |
| PMID: | 38663130 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-3557 |
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| DOI: | 10.1016/j.saa.2024.124335 |