دورية أكاديمية
To be or not to B27 positive: implications for the phenotypes of axial spondyloarthritis outcomes. Data from a large multiracial cohort from the Brazilian Registry of Spondyloarthritis.
| العنوان: | To be or not to B27 positive: implications for the phenotypes of axial spondyloarthritis outcomes. Data from a large multiracial cohort from the Brazilian Registry of Spondyloarthritis. |
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| المؤلفون: | Resende GG; Hospital das Clínicas da UFMG, Belo Horizonte, Brazil. gustavogomesresende@yahoo.com.br.; Serviço de Reumatologia do Hospital das Clínicas da Universidade Federal de Minas Gerais, Alameda Álvaro Celso, 175/2nd floor, Santa Efigênia, Belo Horizonte, MG, Brazil. gustavogomesresende@yahoo.com.br., Saad CGS; Faculdade de Medicina da USP, São Paulo, Brazil., Marques CDL; Hospital das Clínicas da UFPE, Recife, Brazil., Ribeiro SLE; Faculdade de Medicina da UFAM, Manaus, Brazil., de Oliveira Gavi MBR; Universidade Federal do Espírito Santo, Vitória, Brazil., Yazbek MA; Universidade Estadual de Campinas, Campinas, Brazil., de Oliveira Marinho A; Fundação Hospital do Acre, Rio Branco, Brazil., de Cássia Menin R; Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, Brazil., Ochtrop MLG; Universidade Estadual do Rio de Janeiro, Rio de Janeiro, Brazil., Soares AM; Hospital Universitário da UFSC, Florianópolis, Brazil., Cavalcanti NG; Hospital das Clínicas da UFPE, Recife, Brazil., Carneiro JN; Hospital de Base do Distrito Federal, Brasília, Brazil., Werner de Castro GR; Hospital Governador Celso Ramos, Florianópolis, Brazil., Fernandes JMC; Universidade Federal do Maranhão, São Luís, Brazil., da Cruz Ribeiro E Souza E; Hospital de Clínicas da UFU, Uberlândia, Brazil., de Menezes Alvarenga CQ; Santa Casa de Belo Horizonte, Belo Horizonte, Brazil., de Abreu Vieira RMR; Universidade Estadual do Ceará, Fortaleza, Brazil., Machado NP; Universidade Federal do Paraná, Curitiba, Brazil., Ximenes AC; Hospital Geral de Goiânia, Goiânia, Brazil., Gazzeta MO; Santa Casa do Rio de Janeiro, Rio de Janeiro, Brazil., de Albuquerque CP; Hospital Universitário de Brasília, Brasília, Brazil., Skare TL; Hospital Universitário Evangélico Mackenzie, Curitiba, Brazil., Waldemar Keiserman M; Faculdade de Medicina da PUCRS, Porto Alegre, Brazil., Kohem CL; Faculdade de Medicina da UFRGS, Porto Alegre, Brazil., Benacon GS; Faculdade de Medicina da UFAM, Manaus, Brazil., Rocha VFS; Faculdade de Medicina da UFAM, Manaus, Brazil., da Cruz Lage R; Hospital das Clínicas da UFMG, Belo Horizonte, Brazil., Malheiro OB; Hospital das Clínicas da UFMG, Belo Horizonte, Brazil., Golebiovski RTM; Escola Paulista de Medicina - UNIFESP, São Paulo, Brazil., Oliveira TL; Escola Paulista de Medicina - UNIFESP, São Paulo, Brazil., Duque RH; Universidade Federal do Espírito Santo, Vitória, Brazil., Londe AC; Universidade Estadual de Campinas, Campinas, Brazil., de Medeiros Pinheiro M; Escola Paulista de Medicina - UNIFESP, São Paulo, Brazil., Sampaio-Barros PD; Faculdade de Medicina da USP, São Paulo, Brazil. |
| المصدر: | Advances in rheumatology (London, England) [Adv Rheumatol] 2024 Apr 26; Vol. 64 (1), pp. 33. Date of Electronic Publication: 2024 Apr 26. |
| نوع المنشور: | Journal Article; Observational Study; Multicenter Study; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 101734172 Publication Model: Electronic Cited Medium: Internet ISSN: 2523-3106 (Electronic) Linking ISSN: 25233106 NLM ISO Abbreviation: Adv Rheumatol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [London] : BioMed Central, [2018]- |
| مواضيع طبية MeSH: | HLA-B27 Antigen*/blood , HLA-B27 Antigen*/genetics , Registries* , Phenotype* , Axial Spondyloarthritis*, Humans ; Male ; Brazil/epidemiology ; Female ; Adult ; Middle Aged ; Prospective Studies ; Sex Factors ; Cohort Studies ; Quality of Life ; Spondylarthritis/ethnology ; Age of Onset ; Severity of Illness Index |
| مستخلص: | Background: There is a remarkable variability in the frequency of HLA-B27 positivity in patients with spondyloarthritis (SpA), which may be associated with different clinical presentations worldwide. However, there is a lack of data considering ethnicity and sex on the evaluation of the main clinical and prognostic outcomes in mixed-race populations. The aim of this study was to evaluate the frequency of HLA-B27 and its correlation with disease parameters in a large population of patients from the Brazilian Registry of Spondyloarthritis (RBE). Methods: The RBE is a multicenter, observational, prospective cohort that enrolled patients with SpA from 46 centers representing all five geographic regions of Brazil. The inclusion criteria were as follow: (1) diagnosis of axSpA by an expert rheumatologist; (2) age ≥18 years; (3) classification according to ASAS axial. The following data were collected via a standardized protocol: demographic data, disease parameters and treatment historical. Results: A total of 1096 patients were included, with 73.4% HLA-B27 positivity and a mean age of 44.4 (±13.2) years. Positive HLA-B27 was significantly associated with male sex, earlier age at disease onset and diagnosis, uveitis, and family history of SpA. Conversely, negative HLA-B27 was associated with psoriasis, higher peripheral involvement and disease activity, worse quality of life and mobility. Conclusions: Our data showed that HLA-B27 positivity was associated with a classic axSpA pattern quite similar to that of Caucasian axSpA patients around the world. Furthermore, its absence was associated with peripheral manifestations and worse outcomes, suggesting a relevant phenotypic difference in a highly miscegenated population. (© 2024. The Author(s).) |
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| فهرسة مساهمة: | Keywords: ASDAS-CRP; Ankylosing spondylitis; Axial spondyloarthritis; Genetics; HLA-B27; Register-study |
| المشرفين على المادة: | 0 (HLA-B27 Antigen) |
| تواريخ الأحداث: | Date Created: 20240426 Date Completed: 20240427 Latest Revision: 20240628 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1186/s42358-024-00372-0 |
| PMID: | 38671475 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 2523-3106 |
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| DOI: | 10.1186/s42358-024-00372-0 |