دورية أكاديمية
Investigating the Neuroprotective and Cognitive-Enhancing Effects of Bacopa monnieri : A Systematic Review Focused on Inflammation, Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis.
العنوان: | Investigating the Neuroprotective and Cognitive-Enhancing Effects of Bacopa monnieri : A Systematic Review Focused on Inflammation, Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis. |
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المؤلفون: | Valotto Neto LJ; Department of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), Marília 17525-902, SP, Brazil.; Department of Education, Government of Uttarakhand, Nainital 263001, India., Reverete de Araujo M; Department of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), Marília 17525-902, SP, Brazil., Moretti Junior RC; Department of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), Marília 17525-902, SP, Brazil., Mendes Machado N; Department of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), Marília 17525-902, SP, Brazil., Joshi RK; Department of Education, Government of Uttarakhand, Nainital 263001, India., Dos Santos Buglio D; Department of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), Marília 17525-902, SP, Brazil., Barbalho Lamas C; Department of Gerontology, School of Gerontology, Federal University of São Carlos (UFSCar), São Carlos 13565-905, SP, Brazil., Direito R; Laboratory of Systems Integration Pharmacology, Clinical & Regulatory Science, Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy de Farmácia, University of Lisboa, 1649-003 Lisbon, Portugal.; Faculty of Pharmacy, University of Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisbon, Portugal., Fornari Laurindo L; Department of Biochemistry and Pharmacology, School of Medicine, Medical School of Marilia (FAMEMA), Marília 17519-030, SP, Brazil., Tanaka M; Danube Neuroscience Research Laboratory, HUN-REN-SZTE Neuroscience Research Group, Hungarian Research Network, University of Szeged (HUN-REN-SZTE), Tisza Lajos krt. 113, H-6725 Szeged, Hungary., Barbalho SM; Department of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), Marília 17525-902, SP, Brazil.; Postgraduate Program in Structural and Functional Interactions in Rehabilitation, School of Medicine, Universidade de Marília (UNIMAR), Marília 17525-902, SP, Brazil.; Department of Biochemistry and Nutrition, School of Food and Technology of Marília (FATEC), Marília 17500-000, SP, Brazil. |
المصدر: | Antioxidants (Basel, Switzerland) [Antioxidants (Basel)] 2024 Mar 25; Vol. 13 (4). Date of Electronic Publication: 2024 Mar 25. |
نوع المنشور: | Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101668981 Publication Model: Electronic Cited Medium: Print ISSN: 2076-3921 (Print) Linking ISSN: 20763921 NLM ISO Abbreviation: Antioxidants (Basel) Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI AG, [2012]- |
مستخلص: | The aging of the global population has increased the prevalence of neurodegenerative conditions. Bacopa monnieri (BM), an herb with active compounds, such as bacosides A and B, betulinic acid, loliolide, asiatic acid, and quercetin, demonstrates the potential for brain health. Limited research has been conducted on the therapeutic applications of BM in neurodegenerative conditions. This systematic review aims to project BM's beneficial role in brain disorders. BM has anti-apoptotic and antioxidant actions and can repair damaged neurons, stimulate kinase activity, restore synaptic function, improve nerve transmission, and increase neuroprotection. The included twenty-two clinical trials demonstrated that BM can reduce Nuclear Factor-κB phosphorylation, improve emotional function, cognitive functions, anhedonia, hyperactivity, sleep routine, depression, attention deficit, learning problems, memory retention, impulsivity, and psychiatric problems. Moreover, BM can reduce the levels of pro-inflammatory biomarkers and oxidative stress. Here, we highlight that BM provides notable therapeutic benefits and can serve as a complementary approach for the care of patients with neurodegenerative conditions associated with brain disorders. This review adds to the growing interest in natural products and their potential therapeutic applications by improving our understanding of the mechanisms underlying cognitive function and neurodegeneration and informing the development of new therapeutic strategies for neurodegenerative diseases. |
References: | J Ayurveda Integr Med. 2020 Oct-Dec;11(4):440-447. (PMID: 32978047) Sci Rep. 2024 Jan 3;14(1):308. (PMID: 38172290) Nutrients. 2020 Dec 27;13(1):. (PMID: 33375429) Clin Drug Investig. 2014 Dec;34(12):857-69. (PMID: 25316430) Transl Neurodegener. 2024 Jan 8;13(1):3. (PMID: 38191451) Exp Gerontol. 2022 May;161:111731. (PMID: 35143871) Sci Rep. 2021 Jan 12;11(1):596. (PMID: 33436817) Cells. 2018 Jul 21;7(7):. (PMID: 30037060) Acta Radiol. 2024 Apr;65(4):359-366. (PMID: 38196180) Nat Aging. 2024 Jan;4(1):33-47. (PMID: 38195725) Cells. 2022 Aug 21;11(16):. (PMID: 36010683) Neurobiol Aging. 2021 Nov;107:86-95. (PMID: 34416493) J Oleo Sci. 2021 Jul 1;70(7):875-884. (PMID: 34121028) Mol Ther. 2024 Mar 6;32(3):783-799. (PMID: 38196192) Planta Med. 2020 May;86(8):565-570. (PMID: 32325509) Food Chem Toxicol. 2020 Jul;141:111367. (PMID: 32335210) Neurochem Res. 2016 Nov;41(11):3083-3094. (PMID: 27506204) Neural Regen Res. 2024 Apr;19(4):846-854. (PMID: 37843220) CNS Neurol Disord Drug Targets. 2023;22(3):441-451. (PMID: 35021981) Arch Biochem Biophys. 2021 May 15;702:108698. (PMID: 33259796) Antioxidants (Basel). 2021 May 27;10(6):. (PMID: 34071797) Environ Toxicol Pharmacol. 2009 Jan;27(1):62-9. (PMID: 21783922) Immun Ageing. 2024 Jan 6;21(1):4. (PMID: 38184585) J Pharm Biomed Anal. 2022 Feb 5;209:114478. (PMID: 34894460) Sleep Sci. 2023 Sep 11;16(3):e362-e367. (PMID: 38196764) Ageing Res Rev. 2021 Sep;70:101416. (PMID: 34325072) PLoS One. 2023 Jul 19;18(7):e0288045. (PMID: 37467176) Molecules. 2021 Sep 14;26(18):. (PMID: 34577056) Can J Physiol Pharmacol. 2012 May;90(5):595-606. (PMID: 22472017) Phytother Res. 2008 Dec;22(12):1629-34. (PMID: 18683852) Clin Geriatr Med. 2020 Feb;36(1):1-12. (PMID: 31733690) J Am Coll Cardiol. 2022 Feb 8;79(5):482-503. (PMID: 35115105) Pharmaceutics. 2023 Jan 10;15(1):. (PMID: 36678859) Int J Biol Macromol. 2023 Apr 15;234:123171. (PMID: 36716837) Biology (Basel). 2023 Apr 19;12(4):. (PMID: 37106820) Curr Drug Deliv. 2024;21(3):326-338. (PMID: 36650626) Biology (Basel). 2023 Nov 20;12(11):. (PMID: 37998052) Crit Rev Biotechnol. 2023 Sep;43(6):956-970. (PMID: 35819370) Evid Based Complement Alternat Med. 2013;2013:294501. (PMID: 24078822) Biomolecules. 2021 Apr 08;11(4):. (PMID: 33917843) NPJ Parkinsons Dis. 2024 Jan 8;10(1):11. (PMID: 38191580) Fitoterapia. 2013 Jun;87:7-10. (PMID: 23506783) Phytother Res. 2014 Apr;28(4):551-9. (PMID: 23788517) Front Endocrinol (Lausanne). 2023 Jul 03;14:1217730. (PMID: 37465125) Syst Rev. 2023 Aug 17;12(1):143. (PMID: 37592293) Anal Cell Pathol (Amst). 2021 Nov 11;2021:8900122. (PMID: 34804779) Microbiome. 2021 Dec 20;9(1):244. (PMID: 34930485) J Ethnopharmacol. 2017 Feb 2;197:92-100. (PMID: 27473605) BMJ. 2021 Mar 29;372:n71. (PMID: 33782057) Rejuvenation Res. 2013 Aug;16(4):313-26. (PMID: 23772955) Curr Top Med Chem. 2022;22(23):1909-1929. (PMID: 35043757) Molecules. 2020 Nov 30;25(23):. (PMID: 33265939) Appl Microbiol Biotechnol. 2022 Mar;106(5-6):1837-1854. (PMID: 35218388) Future Healthc J. 2019 Mar;6(Suppl 1):69. (PMID: 31363591) Planta Med. 2011 May;77(8):804-8. (PMID: 21154199) Colloids Surf B Biointerfaces. 2023 Jan;221:112982. (PMID: 36347184) Molecules. 2022 Apr 13;27(8):. (PMID: 35458696) Endocrinology. 2021 Nov 1;162(11):. (PMID: 34467976) Org Biomol Chem. 2023 Aug 30;21(34):7018-7023. (PMID: 37594182) Antioxidants (Basel). 2022 Sep 27;11(10):. (PMID: 36290632) Cell. 2023 Feb 16;186(4):693-714. (PMID: 36803602) J Clin Transl Res. 2023 Jan 17;9(1):50-58. (PMID: 37032999) Adv Clin Exp Med. 2023 Jun;32(6):607-612. (PMID: 37278106) Chem Biodivers. 2023 Jan;20(1):e202200684. (PMID: 36480442) Curr Drug Targets. 2022;23(9):889-901. (PMID: 35297345) Open Med. 2009;3(3):e123-30. (PMID: 21603045) Neurochem Res. 2013 Jan;38(1):141-52. (PMID: 23076629) Biomolecules. 2022 Jan 07;12(1):. (PMID: 35053246) Neuropsychopharmacology. 2002 Aug;27(2):279-81. (PMID: 12093601) Degener Neurol Neuromuscul Dis. 2023 Dec 31;13:111-129. (PMID: 38196559) Nat Rev Neurol. 2024 Feb;20(2):67-83. (PMID: 38195712) J Prev Alzheimers Dis. 2017;4(1):12-15. (PMID: 29188854) Int J Mol Sci. 2022 May 25;23(11):. (PMID: 35682615) Phytomedicine. 2024 Feb;124:155272. (PMID: 38181530) Braz J Biol. 2021 Oct-Dec;81(4):1133-1143. (PMID: 33111928) Curr Pharm Biotechnol. 2022;23(1):123-139. (PMID: 33573549) Indian J Biochem Biophys. 2010 Apr;47(2):75-82. (PMID: 20521619) J Affect Disord. 2022 Jul 1;308:229-235. (PMID: 35413358) Int J Mol Sci. 2023 Feb 02;24(3):. (PMID: 36769222) Cells. 2022 Feb 05;11(3):. (PMID: 35159361) Int J Mol Sci. 2022 Oct 25;23(21):. (PMID: 36361643) J Altern Complement Med. 2008 Jul;14(6):707-13. (PMID: 18611150) Neurosci Biobehav Rev. 2024 Feb;157:105542. (PMID: 38215803) J Ethnopharmacol. 2024 Mar 25;322:117584. (PMID: 38104874) Lancet. 2021 Apr 24;397(10284):1577-1590. (PMID: 33667416) Drug Discov Today. 2023 Dec;28(12):103802. (PMID: 37858630) Nutrients. 2015 Dec 02;7(12):9931-45. (PMID: 26633481) J Am Coll Cardiol. 2020 Mar 3;75(8):942-951. (PMID: 32130930) Biotechnol Appl Biochem. 2022 Apr;69(2):726-734. (PMID: 33687113) Food Funct. 2022 Jun 20;13(12):6665-6673. (PMID: 35647710) Int J Biol Macromol. 2023 Aug 1;245:125364. (PMID: 37315665) J Neuropathol Exp Neurol. 2024 Jan 19;83(2):79-93. (PMID: 38193356) Int J Phytoremediation. 2021;23(1):72-79. (PMID: 32657139) Front Neurosci. 2023 Dec 19;17:1311157. (PMID: 38192507) Molecules. 2021 May 15;26(10):. (PMID: 34063409) RSC Adv. 2019 Dec 4;9(68):40109-40117. (PMID: 35541380) Interact J Med Res. 2022 Aug 1;11(2):e38542. (PMID: 35612544) Mol Aspects Med. 2022 Aug;86:101099. (PMID: 35689974) Int J Mol Sci. 2022 Jan 25;23(3):. (PMID: 35163253) Ann Indian Acad Neurol. 2020 Nov-Dec;23(6):767-773. (PMID: 33688125) Heliyon. 2023 Sep 21;9(10):e20385. (PMID: 37767490) Crit Rev Food Sci Nutr. 2024 Jan 8;:1-23. (PMID: 38189347) J Clin Hypertens (Greenwich). 2022 Sep;24(9):1204-1217. (PMID: 36196471) Indian J Psychiatry. 2006 Oct;48(4):238-42. (PMID: 20703343) Molecules. 2020 Jan 28;25(3):. (PMID: 32012948) Molecules. 2020 Dec 08;25(24):. (PMID: 33302541) Adv Exp Med Biol. 2021;1328:287-305. (PMID: 34981485) Int Immunopharmacol. 2013 Feb;15(2):260-74. (PMID: 23257614) Acta Psychiatr Scand. 2023 Nov;148(5):463-466. (PMID: 37548028) Psychopharmacology (Berl). 2001 Aug;156(4):481-4. (PMID: 11498727) Aging Cell. 2022 Oct;21(10):e13704. (PMID: 36056774) Biomed Pharmacother. 2022 Sep;153:113469. (PMID: 36076495) J Altern Complement Med. 2010 Jul;16(7):753-9. (PMID: 20590480) Mol Neurobiol. 2023 Nov 21;:. (PMID: 37987958) Phytother Res. 2013 Sep;27(9):1407-13. (PMID: 23281132) Nat Commun. 2024 Jan 9;15(1):383. (PMID: 38195627) FASEB J. 2024 Jan 31;38(2):e23387. (PMID: 38193649) Cochrane Database Syst Rev. 2019 Oct 3;10:ED000142. (PMID: 31643080) J Med Food. 2022 Aug;25(8):797-806. (PMID: 35353606) Am J Clin Exp Immunol. 2023 Dec 15;12(6):109-126. (PMID: 38187366) Transl Neurodegener. 2024 Jan 9;13(1):4. (PMID: 38195518) Phytother Res. 2021 Oct;35(10):5668-5679. (PMID: 34254371) Evid Based Complement Alternat Med. 2015;2015:535013. (PMID: 26413124) Int J Mol Sci. 2023 Sep 13;24(18):. (PMID: 37762339) Rocz Panstw Zakl Hig. 2021;72(1):29-39. (PMID: 33882663) PLoS One. 2022 Jun 8;17(6):e0268276. (PMID: 35675265) Evid Based Complement Alternat Med. 2012;2012:606424. (PMID: 23320031) ACS Omega. 2022 May 04;7(19):16260-16269. (PMID: 35601340) Food Funct. 2023 Jul 31;14(15):7222-7239. (PMID: 37464840) Brain Res Bull. 2017 Oct;135:120-128. (PMID: 29032054) Folia Neuropathol. 2024 Jan 04;:. (PMID: 38174688) BMC Complement Altern Med. 2016 Jul 27;16:249. (PMID: 27460904) Brain. 2024 Apr 4;147(4):1190-1196. (PMID: 38193320) Biomed Pharmacother. 2024 Jan;170:115679. (PMID: 38113632) Nat Prod Res. 2023 Jul 10;:1-6. (PMID: 37427984) Mitochondrion. 2021 Nov;61:138-146. (PMID: 34606995) Int J Mol Sci. 2023 Mar 14;24(6):. (PMID: 36982647) Curr Neuropharmacol. 2021;19(9):1442-1467. (PMID: 34315377) Food Funct. 2023 May 22;14(10):4456-4469. (PMID: 37066493) Exp Neurol. 2024 Apr;374:114680. (PMID: 38185314) Transl Neurodegener. 2020 Nov 26;9(1):42. (PMID: 33239064) Molecules. 2023 Oct 16;28(20):. (PMID: 37894595) J Clin Invest. 2022 May 16;132(10):. (PMID: 35575089) Metab Brain Dis. 2022 Feb;37(2):383-396. (PMID: 34817757) Biochem Biophys Res Commun. 2023 Jul 30;667:64-72. (PMID: 37209564) Heliyon. 2022 Dec 05;8(12):e11969. (PMID: 36544836) Curr Alzheimer Res. 2022;19(6):420-439. (PMID: 35692129) Heliyon. 2023 Oct 20;9(11):e21161. (PMID: 37954293) Front Behav Neurosci. 2023 Aug 15;17:1268156. (PMID: 37654442) Mol Neurobiol. 2023 Jan;60(1):303-316. (PMID: 36261695) Indian J Exp Biol. 1996 Jun;34(6):523-6. (PMID: 8792640) J Neurodegener Dis. 2013;2013:972391. (PMID: 26317003) Adv Mind Body Med. 2014 Spring;28(2):10-5. (PMID: 24682000) PLoS One. 2015 Jul 10;10(7):e0131862. (PMID: 26161865) Curr Pharm Des. 2021 Oct 5;27(30):3305-3336. (PMID: 34102964) Curr Opin Gastroenterol. 2024 Mar 1;40(2):99-105. (PMID: 38193299) Evid Based Complement Alternat Med. 2016;2016:4103423. (PMID: 27803728) Int J Mol Sci. 2024 Jan 10;25(2):. (PMID: 38255937) Mol Biol Rep. 2023 Oct;50(10):7967-7979. (PMID: 37535247) Nutr Neurosci. 2016 Dec;19(10):434-446. (PMID: 25153704) BioTechnologia (Pozn). 2021 Dec 22;102(4):399-409. (PMID: 36605598) Pharmacogn Mag. 2015 Apr-Jun;11(42):410-6. (PMID: 25829783) Metab Brain Dis. 2019 Apr;34(2):505-518. (PMID: 30604025) J Invest Surg. 2021 Sep;34(9):935-946. (PMID: 32003261) Acta Biomed. 2020 Nov 09;91(13-S):e2020007. (PMID: 33170159) J Med Food. 2023 Feb;26(2):114-119. (PMID: 36800346) Molecules. 2022 Oct 19;27(20):. (PMID: 36296643) ACS Omega. 2022 Oct 30;7(44):40344-40354. (PMID: 36385888) J Clin Invest. 2022 Jul 1;132(13):. (PMID: 35775483) J Ethnopharmacol. 2024 Mar 1;321:117569. (PMID: 38086513) J Neuroinflammation. 2024 Jan 9;21(1):14. (PMID: 38195485) Curr Comput Aided Drug Des. 2023;19(1):24-36. (PMID: 36221888) Pharmacol Res. 2023 Jan;187:106587. (PMID: 36460279) Int J Mol Sci. 2020 Mar 31;21(7):. (PMID: 32244523) Plant Physiol Biochem. 2021 Sep;166:10-19. (PMID: 34087741) BMJ Neurol Open. 2024 Jan 6;6(1):e000524. (PMID: 38196982) Phytother Res. 2022 Feb;36(2):996-1012. (PMID: 35041248) Phytomedicine. 2011 Feb 15;18(4):317-26. (PMID: 20850955) Heliyon. 2023 Apr 26;9(5):e15853. (PMID: 37180926) Molecules. 2022 May 02;27(9):. (PMID: 35566252) Cent Nerv Syst Agents Med Chem. 2019;19(1):57-66. (PMID: 30644349) J Microbiol Biotechnol. 2023 Sep 28;33(9):1250-1256. (PMID: 37317620) Mol Nutr Food Res. 2023 Dec 24;:e2300245. (PMID: 38143280) Biomolecules. 2020 Apr 02;10(4):. (PMID: 32252235) Front Aging Neurosci. 2023 Mar 01;15:1134775. (PMID: 36936504) Eur J Neurol. 2020 Jan;27(1):27-42. (PMID: 31631455) Virulence. 2024 Dec;15(1):2303853. (PMID: 38197252) Toxicol In Vitro. 2024 Mar;95:105756. (PMID: 38061603) Front Nutr. 2022 Aug 18;9:972379. (PMID: 36061899) Int J Mol Sci. 2022 Jun 23;23(13):. (PMID: 35805990) Front Psychiatry. 2023 Aug 02;14:1264669. (PMID: 37599881) Eur Heart J. 2021 Oct 1;42(37):3856-3865. (PMID: 34324648) Biogerontology. 2012 Apr;13(2):183-95. (PMID: 22143822) Phytother Res. 2020 Sep;34(9):2331-2340. (PMID: 32236999) J Tradit Complement Med. 2019 Oct 04;10(5):460-470. (PMID: 32953562) J Ethnopharmacol. 2022 Jul 15;293:115199. (PMID: 35346813) Appl Microbiol Biotechnol. 2022 Mar;106(5-6):1799-1811. (PMID: 35201388) Neurochem Int. 2018 Dec;121:98-107. (PMID: 30296463) Biomedicines. 2022 Nov 22;10(12):. (PMID: 36551755) Transl Psychiatry. 2024 Jan 15;14(1):24. (PMID: 38225222) Nat Prod Res. 2023 Sep 21;:1-6. (PMID: 37732634) J Neurophysiol. 2024 Feb 1;131(2):241-260. (PMID: 38197176) Metab Brain Dis. 2020 Mar;35(3):517-525. (PMID: 31834548) Neurochem Res. 2012 Oct;37(10):2167-77. (PMID: 22837048) Enferm Clin (Engl Ed). 2024 Jan-Feb;34(1):4-13. (PMID: 38185371) Cells. 2020 Jul 14;9(7):. (PMID: 32674367) |
فهرسة مساهمة: | Keywords: Alzheimer’s disease; Bacopa monnieri; cognition; inflammation; mitochondrial dysfunction; neurodegenerative diseases; oxidative stress |
تواريخ الأحداث: | Date Created: 20240427 Latest Revision: 20240429 |
رمز التحديث: | 20240429 |
مُعرف محوري في PubMed: | PMC11047749 |
DOI: | 10.3390/antiox13040393 |
PMID: | 38671841 |
قاعدة البيانات: | MEDLINE |
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