دورية أكاديمية
أعرض في EDS

Modeling PAH Mixture Interactions in a Human In Vitro Organotypic Respiratory Model.

التفاصيل البيبلوغرافية
العنوان: Modeling PAH Mixture Interactions in a Human In Vitro Organotypic Respiratory Model.
المؤلفون: Colvin VC; Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA.; OSU/PNNL Superfund Research Program, Oregon State University, Corvallis, OR 97331, USA., Bramer LM; OSU/PNNL Superfund Research Program, Oregon State University, Corvallis, OR 97331, USA.; Pacific Northwest National Laboratory, Richland, WA 99352, USA., Rivera BN; Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA.; OSU/PNNL Superfund Research Program, Oregon State University, Corvallis, OR 97331, USA., Pennington JM; Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA., Waters KM; OSU/PNNL Superfund Research Program, Oregon State University, Corvallis, OR 97331, USA.; Pacific Northwest National Laboratory, Richland, WA 99352, USA., Tilton SC; Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA.; OSU/PNNL Superfund Research Program, Oregon State University, Corvallis, OR 97331, USA.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Apr 13; Vol. 25 (8). Date of Electronic Publication: 2024 Apr 13.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Polycyclic Aromatic Hydrocarbons*/toxicity , Polycyclic Aromatic Hydrocarbons*/metabolism , Epithelial Cells*/metabolism , Epithelial Cells*/drug effects, Humans ; Oxidative Stress/drug effects ; DNA Damage/drug effects ; Models, Biological ; Air Pollutants/toxicity ; Cells, Cultured ; Bronchi/metabolism ; Bronchi/cytology ; Bronchi/drug effects ; Biomarkers
مستخلص: One of the most significant challenges in human health risk assessment is to evaluate hazards from exposure to environmental chemical mixtures. Polycyclic aromatic hydrocarbons (PAHs) are a class of ubiquitous contaminants typically found as mixtures in gaseous and particulate phases in ambient air pollution associated with petrochemicals from Superfund sites and the burning of fossil fuels. However, little is understood about how PAHs in mixtures contribute to toxicity in lung cells. To investigate mixture interactions and component additivity from environmentally relevant PAHs, two synthetic mixtures were created from PAHs identified in passive air samplers at a legacy creosote site impacted by wildfires. The primary human bronchial epithelial cells differentiated at the air-liquid interface were treated with PAH mixtures at environmentally relevant proportions and evaluated for the differential expression of transcriptional biomarkers related to xenobiotic metabolism, oxidative stress response, barrier integrity, and DNA damage response. Component additivity was evaluated across all endpoints using two independent action (IA) models with and without the scaling of components by toxic equivalence factors. Both IA models exhibited trends that were unlike the observed mixture response and generally underestimated the toxicity across dose suggesting the potential for non-additive interactions of components. Overall, this study provides an example of the usefulness of mixture toxicity assessment with the currently available methods while demonstrating the need for more complex yet interpretable mixture response evaluation methods for environmental samples.
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معلومات مُعتمدة: P42 ES016465 United States ES NIEHS NIH HHS; P30 ES030287 United States ES NIEHS NIH HHS; T32 ES07060 United States ES NIEHS NIH HHS
فهرسة مساهمة: Keywords: 3D in vitro models; chemical interactions; lung cells; mixtures; polycyclic aromatic hydrocarbons
المشرفين على المادة: 0 (Polycyclic Aromatic Hydrocarbons)
0 (Air Pollutants)
0 (Biomarkers)
تواريخ الأحداث: Date Created: 20240427 Date Completed: 20240427 Latest Revision: 20240429
رمز التحديث: 20240429
مُعرف محوري في PubMed: PMC11050152
DOI: 10.3390/ijms25084326
PMID: 38673911
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms25084326