دورية أكاديمية
Homogenized and Lyophilized Amniotic Membrane Dressings for the Treatment of Diabetic Foot Ulcers in Ambulatory Patients.
| العنوان: | Homogenized and Lyophilized Amniotic Membrane Dressings for the Treatment of Diabetic Foot Ulcers in Ambulatory Patients. |
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| المؤلفون: | Carro GV; Diabetic Foot Unit, Hospital Nacional Profesor Alejandro Posadas, El Paloma, Buenos Aires, Argentina., Guerbi X; Universidad Nacional de La Plata, La Plata, Buenos Aires, Argentina.; Unidad 4 Centro de Medicina Traslacional (CEMET), Hospital de Alta Complejidad en Red El Cruce, Florencio Varela, Buenos Aires, Argentina., Berra M; AmniosBMA Tissue Bank, Buenos Aires, Argentina., Rodriguez MG; Diabetic Foot Unit, Hospital Nacional Profesor Alejandro Posadas, El Paloma, Buenos Aires, Argentina., Noli ML; Diabetic Foot Unit, Hospital Nacional Profesor Alejandro Posadas, El Paloma, Buenos Aires, Argentina., Fuentes M; Diabetic Foot Unit, Hospital Nacional Profesor Alejandro Posadas, El Paloma, Buenos Aires, Argentina., Ticona MA; Diabetic Foot Unit, Hospital Nacional Profesor Alejandro Posadas, El Paloma, Buenos Aires, Argentina., Michelini F; CONICET, Buenos Aires, Argentina.; Unidad 4 Centro de Medicina Traslacional (CEMET), Hospital de Alta Complejidad en Red El Cruce, Florencio Varela, Buenos Aires, Argentina., Berra A; CONICET, Buenos Aires, Argentina.; Unidad 4 Centro de Medicina Traslacional (CEMET), Hospital de Alta Complejidad en Red El Cruce, Florencio Varela, Buenos Aires, Argentina. |
| المصدر: | Foot & ankle international [Foot Ankle Int] 2024 Aug; Vol. 45 (8), pp. 905-915. Date of Electronic Publication: 2024 Apr 27. |
| نوع المنشور: | Journal Article; Observational Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Sage Publications Country of Publication: United States NLM ID: 9433869 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1944-7876 (Electronic) Linking ISSN: 10711007 NLM ISO Abbreviation: Foot Ankle Int Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2013- : Thousand Oaks, CA : Sage Publications Original Publication: Baltimore, MD : Williams & Wilkins, c1994- |
| مواضيع طبية MeSH: | Diabetic Foot*/therapy , Wound Healing* , Amnion*/transplantation, Humans ; Middle Aged ; Female ; Male ; Longitudinal Studies ; Biological Dressings ; Adult ; Freeze Drying ; Bandages ; Aged |
| مستخلص: | Background: Diabetic foot ulcers (DFUs) constitute a complication that occurs in 19% to 34% of patients with diabetes mellitus (DM). The aim of this study is to describe median days to healing, average velocity of wound closure, and percentage of wound surface closed at 3, 6, and 12 weeks through the use of homogenized and lyophilized amniotic membrane (hAMpe) dressings for the treatment of DFUs in ambulatory patients. Methods: An observational, descriptive, longitudinal study was performed. Patients presenting with granulation-based DFU, after proper debridement, were included from August 19, 2021, until July 14, 2023. hAMpe dressings placed every 3 days were used for the treatment of these ulcers. Results: Sixteen patients were included with a mean age of 52.38 (8.07) years. The analyzed lesions were postsurgical ulcers in 15 of the 16 included patients. Median ulcer size was 19.5 cm 2 (6.12-36). The median ABI was 1.10 (1-1.14). The median days to healing was 96 (71-170). The median percentage closure of the wound at 3 weeks was 41% (28.9%-55.3%), at 6 weeks it was 68.2% (48.6%-74.2%), and at 12 weeks it was 100% (81%-100%). The average velocity closure was 1.04% per day (95% CI 0.71%-1.31%). It was higher during the closure of the first 50% of the ulcer, 2.12% per day (95% CI 0.16%-4.09%), and decreased from 50% to 25% of the ulcer size to 0.67% per day (95% CI 0.23%-1.10%) and from 25% to closure to 0.47% per day (95% CI 0.14%-0.80%), P < .001. Conclusion: These results are difficult to compare to other studies given the higher surface area of the ulcers included in our sample. The development of hAMpe dressings enables patients to apply them without requiring assistance from health care teams and was not associated with any recognized complications. Competing Interests: Declaration of Conflicting InterestsThe author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Mariano Berra, BPharm, reports non-financial interests from AmniosBMA Tissue Bank (non profit organization), as Technical Director. Alejandro Berra, PhD, reports participation on a data safety monitoring board or advisory board from AmniosBMA Tissue Bank (non profit organization), as R&D Director. Disclosure forms for all authors are available online. |
| فهرسة مساهمة: | Keywords: advanced wound healing; amniotic membrane; diabetic foot; hAMpe; velocity wound closure; wound healing |
| تواريخ الأحداث: | Date Created: 20240427 Date Completed: 20240823 Latest Revision: 20240827 |
| رمز التحديث: | 20240828 |
| DOI: | 10.1177/10711007241243373 |
| PMID: | 38676564 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1944-7876 |
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| DOI: | 10.1177/10711007241243373 |