دورية أكاديمية
Structural and functional insights into yeast Tbf1 as an atypical telomeric repeat-binding factor.
| العنوان: | Structural and functional insights into yeast Tbf1 as an atypical telomeric repeat-binding factor. |
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| المؤلفون: | Wu Z; Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China. Electronic address: zhenfwu@ucas.ac.cn., Gu X; State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China., Zha L; Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China., Yang Q; Department of Hematology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China., Zhou Y; Department of Hematology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China. Electronic address: zhou_yuanze@163.com., Zeng Z; Hunan Provincial Key Laboratory of the TCM Agricultural Biogenomics, Changsha Medical University, Changsha 410219, China. Electronic address: zengzx@126.com. |
| المصدر: | Structure (London, England : 1993) [Structure] 2024 Jul 11; Vol. 32 (7), pp. 889-898.e3. Date of Electronic Publication: 2024 Apr 26. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 101087697 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-4186 (Electronic) Linking ISSN: 09692126 NLM ISO Abbreviation: Structure Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2000- : Cambridge, Mass. : Cell Press Original Publication: London : Current Biology, c1993- |
| مواضيع طبية MeSH: | Schizosaccharomyces*/metabolism , Schizosaccharomyces*/chemistry , Schizosaccharomyces*/genetics , Schizosaccharomyces pombe Proteins*/chemistry , Schizosaccharomyces pombe Proteins*/metabolism , Schizosaccharomyces pombe Proteins*/genetics , Telomere-Binding Proteins*/metabolism , Telomere-Binding Proteins*/chemistry, Amino Acid Sequence ; Binding Sites ; Crystallography, X-Ray ; DNA-Binding Proteins ; Models, Molecular ; Protein Binding ; Protein Domains ; Protein Multimerization ; Saccharomyces cerevisiae Proteins/chemistry ; Saccharomyces cerevisiae Proteins/metabolism ; Saccharomyces cerevisiae Proteins/genetics ; Telomere/metabolism ; Telomere/chemistry ; Transcription Factors |
| مستخلص: | Telomeric repeat-binding factor 1 (Tbf1) has a similar architecture as the TRF family of telomeric proteins and plays important roles in both telomere homeostasis and ribosome regulation. However, the molecular basis of why Tbf1 has such different functions compared to other TRFs remains unclear. Here, we present the crystal structures of the TRF homology (TRFH) and Myb-L domains from Schizosaccharomyces pombe Tbf1 (spTbf1). TRFH-mediated homodimerization is essential for spTbf1 stability. Importantly, spTbf1 Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2024 Elsevier Inc. All rights reserved.) |
| المشرفين على المادة: | 0 (DNA-Binding Proteins) 0 (Saccharomyces cerevisiae Proteins) 0 (Schizosaccharomyces pombe Proteins) 0 (TBF1 protein, S pombe) 0 (Telomere-Binding Proteins) 0 (Transcription Factors) |
| تواريخ الأحداث: | Date Created: 20240427 Date Completed: 20240712 Latest Revision: 20240801 |
| رمز التحديث: | 20240802 |
| DOI: | 10.1016/j.str.2024.04.002 |
| PMID: | 38677290 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1878-4186 |
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| DOI: | 10.1016/j.str.2024.04.002 |