دورية أكاديمية
miRNAs dysregulation in ankylosing spondylitis: A review of implications for disease mechanisms, and diagnostic markers.
| العنوان: | miRNAs dysregulation in ankylosing spondylitis: A review of implications for disease mechanisms, and diagnostic markers. |
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| المؤلفون: | Mohammed OA; Department of Pharmacology, College of Medicine, University of Bisha, Bisha 61922, Saudi Arabia., Alghamdi M; Department of Internal Medicine, Division of Rheumatology, College of Medicine, University of Bisha, Bisha 61922, Saudi Arabia., Adam MIE; Department of Medical Education and Internal Medicine, College of Medicine, University of Bisha, Bisha 61922, Saudi Arabia., BinAfif WF; Department of Internal Medicine, College of Medicine, University of Bisha, Bisha 61922, Saudi Arabia., Alfaifi J; Department of Child Health, College of Medicine, University of Bisha, Bisha 61922, Saudi Arabia., Alamri MMS; Department of Family and Community Medicine, College of Medicine, University of Bisha, Bisha 61922, Saudi Arabia., Alqarni AA; Department of Internal Medicine, College of Medicine, University of Bisha, Bisha 61922, Saudi Arabia., Alhalafi AH; Department of Family and Community Medicine, College of Medicine, University of Bisha, Bisha 61922, Saudi Arabia., Bahashwan E; Department of Internal Medicine, Division of Dermatology, College of Medicine, University of Bisha, Bisha 61922, Saudi Arabia., AlQahtani AAJ; Department of Internal Medicine, Division of Dermatology, College of Medicine, University of Bisha, Bisha 61922, Saudi Arabia., Ayed A; Department of Surgery, College of Medicine, University of Bisha, Bisha 61922, Saudi Arabia., Hassan RH; Dermatology Clinic, Abbasseya Psychiatric Hospital, Abbasseya, Cairo 11517, Egypt., Abdel-Reheim MA; Department of Pharmaceutical Sciences, College of Pharmacy, Shaqra University, Shaqra 11961, Saudi Arabia; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni Suef 62521, Egypt. Electronic address: m.ahmed@su.edu.sa., Abdel Mageed SS; Pharmacology and Toxicology Department, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt., Rezigalla AA; Department of Anatomy, College of Medicine, University of Bisha, Bisha 61922, Saudi Arabia., Doghish AS; Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt; Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City 11231, Cairo, Egypt. Electronic address: ahmed_doghish@azhar.edu.eg. |
| المصدر: | International journal of biological macromolecules [Int J Biol Macromol] 2024 May; Vol. 268 (Pt 2), pp. 131814. Date of Electronic Publication: 2024 Apr 26. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: Guildford, Eng., IPC Science and Technology Press. |
| مواضيع طبية MeSH: | Spondylitis, Ankylosing*/genetics , Spondylitis, Ankylosing*/diagnosis , Spondylitis, Ankylosing*/immunology , MicroRNAs*/genetics , Biomarkers* , Epigenesis, Genetic*, Humans ; Gene Expression Regulation ; Animals ; Signal Transduction |
| مستخلص: | Epigenetic processes, including non-coding RNA, histone modifications, and DNA methylation, play a vital role in connecting the environment to the development of a disorder, especially when there is a favorable genetic background. Ankylosing Spondylitis (AS) is a chronic type of spinal arthritis that highlights the significance of epigenetics in diseases related to autoimmunity and inflammation. MicroRNAs (miRNAs) are small non-coding RNAs that are involved in both normal and aberrant pathological and physiological gene expression. This study focuses on the pathophysiological pathways to clarify the role of miRNAs in AS. We have conducted a thorough investigation of the involvement of miRNAs in several processes, including inflammation, the production of new bone, T-cell activity, and the regulation of pathways such as BMP, Wnt, and TGFβ signaling. Undoubtedly, miRNAs play a crucial role in enhancing our comprehension of the pathophysiology of AS, and their promise as a therapeutic strategy is quickly expanding. Competing Interests: Declaration of competing interest The authors declare they have no conflict of interest. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Ankylosing spondylitis; Pathogenesis; miRNAs |
| المشرفين على المادة: | 0 (MicroRNAs) 0 (Biomarkers) |
| تواريخ الأحداث: | Date Created: 20240427 Date Completed: 20240524 Latest Revision: 20240531 |
| رمز التحديث: | 20240531 |
| DOI: | 10.1016/j.ijbiomac.2024.131814 |
| PMID: | 38677679 |
| قاعدة البيانات: | MEDLINE |
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