دورية أكاديمية
Multi-biomarker response of cyanobacteria Synechocystis salina and Microcystis aeruginosa to diclofenac.
| العنوان: | Multi-biomarker response of cyanobacteria Synechocystis salina and Microcystis aeruginosa to diclofenac. |
|---|---|
| المؤلفون: | Kwidzińska K; University of Gdansk, Faculty of Chemistry, Department of Environmental Analysis, ul. Wita Stwosza 63, 80-308 Gdańsk, Poland. Electronic address: klaudia.kwidzinska@phdstud.ug.edu.pl., Zalewska M; University of Gdansk, Faculty of Biology, Department of Plant Experimental Biology and Biotechnology, ul. Wita Stwosza 59, 80-308 Gdańsk, Poland., Aksmann A; University of Gdansk, Faculty of Biology, Department of Plant Experimental Biology and Biotechnology, ul. Wita Stwosza 59, 80-308 Gdańsk, Poland., Kobos J; University of Gdansk, Faculty of Oceanography and Geography, Department of Marine Biology and Biotechnology, al. Marszałka Piłsudskiego 46, 81-378 Gdynia, Poland., Mazur-Marzec H; University of Gdansk, Faculty of Oceanography and Geography, Department of Marine Biology and Biotechnology, al. Marszałka Piłsudskiego 46, 81-378 Gdynia, Poland., Caban M; University of Gdansk, Faculty of Chemistry, Department of Environmental Analysis, ul. Wita Stwosza 63, 80-308 Gdańsk, Poland. |
| المصدر: | Journal of hazardous materials [J Hazard Mater] 2024 Jun 05; Vol. 471, pp. 134373. Date of Electronic Publication: 2024 Apr 21. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9422688 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3336 (Electronic) Linking ISSN: 03043894 NLM ISO Abbreviation: J Hazard Mater Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier, |
| مواضيع طبية MeSH: | Microcystis*/drug effects , Microcystis*/metabolism , Microcystis*/growth & development , Diclofenac*/toxicity , Diclofenac*/metabolism , Biomarkers*/metabolism , Synechocystis*/metabolism , Synechocystis*/drug effects , Synechocystis*/growth & development , Chlorophyll A*/metabolism, Microcystins/metabolism ; Chlorophyll/metabolism ; Water Pollutants, Chemical/toxicity ; Water Pollutants, Chemical/metabolism ; Photosynthesis/drug effects ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology |
| مستخلص: | The cyanobacterial response to pharmaceuticals is less frequently investigated compared to green algae. Pharmaceuticals can influence not only the growth rate of cyanobacteria culture, but can also cause changes at the cellular level. The effect of diclofenac (DCF) as one of the for cyanobacteria has been rarely tested, and DCF has never been applied with cellular biomarkers. The aim of this work was to test the response of two unicellular cyanobacteria (Synechocystis salina and Microcystis aeruginosa) toward DCF (100 mg L -1 ) under photoautotrophic growth conditions. Such endpoints were analyzed as cells number, DCF uptake, the change in concentrations of photosynthetic pigments, the production of toxins, and chlorophyll a in vivo fluorescence. It was noted that during a 96 h exposure, cell proliferation was not impacted. Nevertheless, a biochemical response was observed. The increased production of microcystin was noted for M. aeruginosa. Due to the negligible absorption of DCF into cells, it is possible that the biochemical changes are induced by an external signal. The application of non-standard biomarkers demonstrates the effect of DCF on microorganism metabolism without a corresponding effect on biomass. The high resistance of cyanobacteria to DCF and the stimulating effect of DCF on the secretion of toxins raise concerns for environment biodiversity. Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Magda Caban reports financial support was provided by National Science Centre Poland. Magda Caban reports a relationship with National Science Centre Poland that includes: funding grants. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Biomarkers of cyanobacteria stress; Cyanobacteria; Cyanotoxins; Diclofenac; Pharmaceutical ecotoxicology |
| المشرفين على المادة: | 144O8QL0L1 (Diclofenac) 0 (Biomarkers) YF5Q9EJC8Y (Chlorophyll A) 0 (Microcystins) 1406-65-1 (Chlorophyll) 0 (Water Pollutants, Chemical) 0 (Anti-Inflammatory Agents, Non-Steroidal) |
| تواريخ الأحداث: | Date Created: 20240428 Date Completed: 20240511 Latest Revision: 20240511 |
| رمز التحديث: | 20240511 |
| DOI: | 10.1016/j.jhazmat.2024.134373 |
| PMID: | 38678710 |
| قاعدة البيانات: | MEDLINE |
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