دورية أكاديمية
أعرض في EDS

Metabolic syndrome and the urinary microbiome of patients undergoing percutaneous nephrolithotomy.

التفاصيل البيبلوغرافية
العنوان: Metabolic syndrome and the urinary microbiome of patients undergoing percutaneous nephrolithotomy.
المؤلفون: Dornbier RA; Loyola University Medical Center, Department of Urology, Maywood, IL, USA., Doshi CP; Loyola University Medical Center, Department of Urology, Maywood, IL, USA., Desai SC; Loyola University Medical Center, Department of Urology, Maywood, IL, USA., Bajic P; Loyola University Medical Center, Department of Urology, Maywood, IL, USA., Van Kuiken M; Loyola University Medical Center, Department of Urology, Maywood, IL, USA., Khemmani M; Loyola University Chicago, Department of Microbiology and Immunology, Maywood, IL, USA., Farooq AV; Loyola University Medical Center, Department of Urology, Maywood, IL, USA., Bresler L; Loyola University Medical Center, Department of Urology, Maywood, IL, USA., Turk TMT; Loyola University Medical Center, Department of Urology, Maywood, IL, USA., Wolfe AJ; Loyola University Chicago, Department of Microbiology and Immunology, Maywood, IL, USA., Baldea KG; Loyola University Medical Center, Department of Urology, Maywood, IL, USA.
المصدر: Asian journal of urology [Asian J Urol] 2024 Apr; Vol. 11 (2), pp. 316-323. Date of Electronic Publication: 2023 Mar 21.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier (Singapore) Pte Ltd Country of Publication: Singapore NLM ID: 101699720 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2214-3882 (Print) Linking ISSN: 22143882 NLM ISO Abbreviation: Asian J Urol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: Singapore : Elsevier (Singapore) Pte Ltd.
Original Publication: [Beijing, China?] : Chinese Urology Association, [2014]-
مستخلص: Objective: To identify possible stone-promoting microbes, we compared the profiles of microbes grown from stones of patients with and without metabolic syndrome (MetS). The association between MetS and urinary stone disease is well established, but the exact pathophysiologic relationship remains unknown. Recent evidence suggests urinary tract dysbiosis may lead to increased nephrolithiasis risk.
Methods: At the time of percutaneous nephrolithotomy, bladder urine and stone fragments were collected from patients with and without MetS. Both sample types were subjected to expanded quantitative urine culture (EQUC) and 16 S ribosomal RNA gene sequencing.
Results: Fifty-seven patients included 12 controls (21.1%) and 45 MetS patients (78.9%). Both cohorts were similar with respect to demographics and non-MetS comorbidities. No controls had uric acid stone composition. By EQUC, bacteria were detected more frequently in MetS stones (42.2%) compared to controls (8.3%) ( p =0.041). Bacteria also were more abundant in stones of MetS patients compared to controls. To validate our EQUC results, we performed 16 S ribosomal RNA gene sequencing. In 12/16 (75.0%) sequence-positive stones, EQUC reliably isolated at least one species of the sequenced genera. Bacteria were detected in both "infectious" and "non-infectious" stone compositions.
Conclusion: Bacteria are more common and more abundant in MetS stones than control stones. Our findings support a role for bacteria in urinary stone disease for patients with MetS regardless of stone composition.
Competing Interests: Wolfe AJ is a member of the Urobiome Therapeutics (Boston, MA, USA) advisory board and the Pathnostics Scientific (Irvine, CA, USA) advisory board. Wolfe AJ has research funding from the Craig H. Neilsen Foundation, Pathnostics (Irvine, CA, USA), and an anonymous donor. The other authors declared no conflict of interest.
(© 2024 Editorial Office of Asian Journal of Urology. Production and hosting by Elsevier B.V.)
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فهرسة مساهمة: Keywords: Metabolic syndrome; Nephrolithiasis; Percutaneous nephrolithotomy; Urinary microbiome; Urolithiasis
تواريخ الأحداث: Date Created: 20240429 Latest Revision: 20240430
رمز التحديث: 20240430
مُعرف محوري في PubMed: PMC11053299
DOI: 10.1016/j.ajur.2022.08.007
PMID: 38680585
قاعدة البيانات: MEDLINE
الوصف
تدمد:2214-3882
DOI:10.1016/j.ajur.2022.08.007