دورية أكاديمية
Design and Synthesis of Polyheterocyclic Compounds Containing Pyrazolopyridopyrimidine Nucleus with Antimicrobial Activities.
| العنوان: | Design and Synthesis of Polyheterocyclic Compounds Containing Pyrazolopyridopyrimidine Nucleus with Antimicrobial Activities. |
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| المؤلفون: | El-Essawy FA; Preparatory Year Deanship. Basic Science Department, Prince Sattam Bin Abdulaziz University, 151, Alkharj, 11942, KSA, Saudi Arabia., Odah MAA; Preparatory Year Deanship. Basic Science Department, Prince Sattam Bin Abdulaziz University, 151, Alkharj, 11942, KSA, Saudi Arabia. |
| المصدر: | ChemistryOpen [ChemistryOpen] 2024 Jun; Vol. 13 (6), pp. e202400070. Date of Electronic Publication: 2024 Apr 29. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-VCH Verlag Country of Publication: Germany NLM ID: 101594811 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2191-1363 (Electronic) Linking ISSN: 21911363 NLM ISO Abbreviation: ChemistryOpen Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Weinheim : Wiley-VCH Verlag |
| مواضيع طبية MeSH: | Microbial Sensitivity Tests* , Pyrimidines*/chemistry , Pyrimidines*/pharmacology , Pyrimidines*/chemical synthesis , Drug Design* , Gram-Negative Bacteria*/drug effects , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemical synthesis , Anti-Bacterial Agents*/chemistry , Gram-Positive Bacteria*/drug effects , Pyrazoles*/chemistry , Pyrazoles*/pharmacology , Pyrazoles*/chemical synthesis, Heterocyclic Compounds/chemistry ; Heterocyclic Compounds/pharmacology ; Structure-Activity Relationship |
| مستخلص: | This study reports the design, synthesis, and antibacterial evaluation of a library of novel polyheterocyclic derivatives featuring a unique fused pyrimidopyridopyrazole moiety. A cyclocondensation reaction between an amino-pyrazolopyridopyrimidine precursor and malonates afforded a series of pyrimidopyridopyrazolopyrimidine derivatives. Further diversification was achieved through nucleophilic cyclocondensation, yielding a collection of complex polyheterocyclic systems encompassing various ring structures. All synthesized compounds were rigorously characterized using spectroscopic techniques and elemental analysis. The antibacterial activity of the newly synthesized compounds was assessed against a panel of Gram-positive and Gram-negative bacteria. Notably, several compounds exhibited promising antibacterial activity, highlighting their potential as leads for the development of novel antibiotics. (© 2024 The Authors. ChemistryOpen published by Wiley-VCH GmbH.) |
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| معلومات مُعتمدة: | IF-PSAU-2023/01/26168 Deputyship for Research & Innovation, Ministry of Education in Saudi Arabia |
| فهرسة مساهمة: | Keywords: Antimicrobial; Cyclocondesation; Polyheterocyclic; Pyrazolopyridopyrimidine; Thiourea |
| المشرفين على المادة: | 0 (Pyrimidines) 0 (Anti-Bacterial Agents) 0 (Pyrazoles) 0 (Heterocyclic Compounds) |
| تواريخ الأحداث: | Date Created: 20240429 Date Completed: 20240610 Latest Revision: 20240612 |
| رمز التحديث: | 20240612 |
| مُعرف محوري في PubMed: | PMC11164023 |
| DOI: | 10.1002/open.202400070 |
| PMID: | 38683824 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2191-1363 |
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| DOI: | 10.1002/open.202400070 |