دورية أكاديمية
أعرض في EDS

Study protocol to assess aflatoxin M1 health risks versus benefits of dairy consumption in Ethiopian children: an epidemiological trial and risk-benefit analysis.

التفاصيل البيبلوغرافية
العنوان: Study protocol to assess aflatoxin M1 health risks versus benefits of dairy consumption in Ethiopian children: an epidemiological trial and risk-benefit analysis.
المؤلفون: Wu F; Department of Food Science and Human Nutrition, Michigan State University, East Lansing, Michigan, USA fwu@msu.edu.; Department of Agricultural, Food, and Resource Economics, Michigan State University, East Lansing, Michigan, USA., Headey D; International Food Policy Research Institute, Washington, District of Columbia, USA., Hirvonen K; International Food Policy Research Institute, Washington, District of Columbia, USA., Pokharel A; Department of Agricultural, Food, and Resource Economics, Michigan State University, East Lansing, Michigan, USA., Tessema M; Ethiopian Public Health Institute, Addis Ababa, Ethiopia.
المصدر: BMJ open [BMJ Open] 2024 Apr 28; Vol. 14 (4), pp. e084257. Date of Electronic Publication: 2024 Apr 28.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : BMJ Publishing Group Ltd, 2011-
مواضيع طبية MeSH: Aflatoxin M1*/analysis , Food Contamination*/analysis , Milk*, Humans ; Ethiopia/epidemiology ; Infant ; Animals ; Risk Assessment/methods ; Female ; Male ; Research Design ; Dairy Products ; Aflatoxin B1/analysis
مستخلص: Introduction: In Sidama, Ethiopia, animal-source foods can be difficult to access. Milk has important nutrients for child growth, but carries the risk of aflatoxin M 1 (AFM 1 ) contamination. AFM 1 is a metabolite of the mycotoxin aflatoxin B 1 (AFB 1 ) in dairy feed; cows secrete AFM 1 in milk when their feed contains AFB 1 produced by Aspergillus fungi in maize, nuts and oilseeds. It is unknown whether AFM 1 compromises child growth and health.
Methods and Analysis: This protocol paper describes our study in Sidama to determine the impact of milk consumption and AFM 1 on child growth in the first 18 months of life. We will collect baseline and end-line data on dairy production, socioeconomic and nutritional factors of 1000 dairy-owning households with children ages 6-18 months at baseline; and gather samples of milk and dairy feed and child anthropometrics. We will conduct phone interviews every 6 months to ascertain changes in practices or child health. Dairy feed will be tested for AFB 1 ; milk for AFM 1 , pathogens and nutrients. Controlling for herd size, socioeconomic, nutritional and behavioural factors, we will determine the association between child anthropometrics and milk consumption, as well as AFM 1 exposure. We will examine whether AFM 1 exposure affects child growth in the first 18 months of life, and weigh the benefits and risks of milk consumption.
Ethics and Dissemination: The protocol is approved by the Institutional Review Boards of the Ethiopian Public Health Institute (EPHI-IRB-481-2022), Michigan State University (STUDY00007996) and International Food Policy Research Institute (DSGD-23-0102). Written informed consent will be obtained from all participants, who may withdraw from the study at any time. Confidentiality of collected data will be given high priority during each stage of data handling. The study's findings will be disseminated through stakeholder workshops, local and international conferences, journal articles and technical reports.
Competing Interests: Competing interests: None declared.
(© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY. Published by BMJ.)
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فهرسة مساهمة: Keywords: Community child health; Epidemiologic studies; Nutrition & dietetics; Public health
المشرفين على المادة: 6795-23-9 (Aflatoxin M1)
9N2N2Y55MH (Aflatoxin B1)
تواريخ الأحداث: Date Created: 20240429 Date Completed: 20240429 Latest Revision: 20240502
رمز التحديث: 20240502
مُعرف محوري في PubMed: PMC11057243
DOI: 10.1136/bmjopen-2024-084257
PMID: 38684249
قاعدة البيانات: MEDLINE
الوصف
تدمد:2044-6055
DOI:10.1136/bmjopen-2024-084257