دورية أكاديمية
Efficacy Assessment of Cerebral Perfusion Augmentation through Functional Connectivity in an Acute Canine Stroke Model.
| العنوان: | Efficacy Assessment of Cerebral Perfusion Augmentation through Functional Connectivity in an Acute Canine Stroke Model. |
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| المؤلفون: | Warioba CS; From the Department of Radiology (C.S.W., M.L., S.P., T.J.C., S.F.), University of Chicago, Chicago, Illinois cswarioba@uchicago.edu., Liu M; From the Department of Radiology (C.S.W., M.L., S.P., T.J.C., S.F.), University of Chicago, Chicago, Illinois., Peñano S; From the Department of Radiology (C.S.W., M.L., S.P., T.J.C., S.F.), University of Chicago, Chicago, Illinois., Carroll TJ; From the Department of Radiology (C.S.W., M.L., S.P., T.J.C., S.F.), University of Chicago, Chicago, Illinois., Foxley S; From the Department of Radiology (C.S.W., M.L., S.P., T.J.C., S.F.), University of Chicago, Chicago, Illinois., Christoforidis G; Mount Carmel Health (G.C.), Columbus, Ohio. |
| المصدر: | AJNR. American journal of neuroradiology [AJNR Am J Neuroradiol] 2024 Sep 09; Vol. 45 (9), pp. 1214-1219. Date of Electronic Publication: 2024 Sep 09. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society of Neuroradiology Country of Publication: United States NLM ID: 8003708 Publication Model: Electronic Cited Medium: Internet ISSN: 1936-959X (Electronic) Linking ISSN: 01956108 NLM ISO Abbreviation: AJNR Am J Neuroradiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oak Brook, IL : American Society of Neuroradiology Original Publication: Baltimore, Williams & Wilkins. |
| مواضيع طبية MeSH: | Disease Models, Animal* , Magnetic Resonance Imaging*/methods , Cerebrovascular Circulation*/drug effects , Cerebrovascular Circulation*/physiology, Animals ; Dogs ; Norepinephrine ; Infarction, Middle Cerebral Artery/diagnostic imaging ; Infarction, Middle Cerebral Artery/physiopathology ; Infarction, Middle Cerebral Artery/drug therapy ; Male ; Stroke/diagnostic imaging ; Stroke/physiopathology ; Stroke/drug therapy ; Vasodilator Agents/administration & dosage ; Vasodilator Agents/pharmacology |
| مستخلص: | Background and Purpose: Ischemic stroke disrupts functional connectivity within the brain's resting-state networks (RSNs), impacting recovery. This study evaluates the effects of norepinephrine and hydralazine (NEH), a cerebral perfusion augmentation therapy, on RSN integrity in a hyperacute canine stroke model. Materials and Methods: Fifteen adult purpose-bred mongrel canines, divided into treatment and control (natural history) groups, underwent endovascular induction of acute middle cerebral artery occlusion (MCAO). Postocclusion, the treatment group received intra-arterial norepinephrine (0.1-1.52 µg/kg/min, adjusted for 25-45 mm Hg above baseline mean arterial pressure) and hydralazine (20 mg). Resting-state fMRI (rs-fMRI) data were acquired with a 3T scanner by using a blood oxygen level dependent-EPI sequence (TR/TE = 1400 ms/20 ms, 2.5 mm slices, 300 temporal positions). Preprocessing included motion correction, spatial smoothing (2.5 mm full width at half maximum), and high-pass filtering (0.01 Hz cutoff). Functional connectivity within RSNs were analyzed through group-level independent component analysis and weighted whole-brain ROI-to-ROI connectome, pre- and post-MCAO. Results: NEH therapy significantly maintained connectivity post-MCAO in the higher-order visual and parietal RSNs, as evidenced by thresholded statistical mapping (threshold-free cluster enhancement P Conclusions: NEH demonstrates potential as a proof-of-concept therapy for maintaining RSN functional connectivity after ischemic stroke, emphasizing the therapeutic promise of perfusion augmentation. These insights reinforce the role of functional connectivity as a measurable end point for stroke intervention efficacy, suggesting clinical translatability for patients with insufficient collateral circulation. (© 2024 by American Journal of Neuroradiology.) |
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| المشرفين على المادة: | X4W3ENH1CV (Norepinephrine) 0 (Vasodilator Agents) |
| تواريخ الأحداث: | Date Created: 20240429 Date Completed: 20240909 Latest Revision: 20240914 |
| رمز التحديث: | 20240914 |
| مُعرف محوري في PubMed: | PMC11392365 |
| DOI: | 10.3174/ajnr.A8320 |
| PMID: | 38684318 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1936-959X |
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| DOI: | 10.3174/ajnr.A8320 |