دورية أكاديمية
Adult Attention Deficit-Hyperactivity Disorder is associated with Lewy Body Disease and Cognitive Impairment: A prospective cohort Study With 15-year Follow-Up.
| العنوان: | Adult Attention Deficit-Hyperactivity Disorder is associated with Lewy Body Disease and Cognitive Impairment: A prospective cohort Study With 15-year Follow-Up. |
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| المؤلفون: | Golimstok Á; Cognitive and Behavior Unit, Department of Neurology (AG, MJGB, MM, WB, MR, MCF), Hospital Italiano de Buenos Aires, Buenos Aires, Argentina; Master of Neuropsychology (AG, MJGB, MM, WB, MCF), University Institute of the Italian Hospital, Buenos Aires, Argentina. Electronic address: angel.golimstok@hospitalitaliano.org.ar., Basalo MJG; Cognitive and Behavior Unit, Department of Neurology (AG, MJGB, MM, WB, MR, MCF), Hospital Italiano de Buenos Aires, Buenos Aires, Argentina; Master of Neuropsychology (AG, MJGB, MM, WB, MCF), University Institute of the Italian Hospital, Buenos Aires, Argentina., Majul M; Cognitive and Behavior Unit, Department of Neurology (AG, MJGB, MM, WB, MR, MCF), Hospital Italiano de Buenos Aires, Buenos Aires, Argentina; Master of Neuropsychology (AG, MJGB, MM, WB, MCF), University Institute of the Italian Hospital, Buenos Aires, Argentina., Berrios W; Cognitive and Behavior Unit, Department of Neurology (AG, MJGB, MM, WB, MR, MCF), Hospital Italiano de Buenos Aires, Buenos Aires, Argentina; Master of Neuropsychology (AG, MJGB, MM, WB, MCF), University Institute of the Italian Hospital, Buenos Aires, Argentina., Rugiero M; Cognitive and Behavior Unit, Department of Neurology (AG, MJGB, MM, WB, MR, MCF), Hospital Italiano de Buenos Aires, Buenos Aires, Argentina., Fernández MC; Cognitive and Behavior Unit, Department of Neurology (AG, MJGB, MM, WB, MR, MCF), Hospital Italiano de Buenos Aires, Buenos Aires, Argentina; Master of Neuropsychology (AG, MJGB, MM, WB, MCF), University Institute of the Italian Hospital, Buenos Aires, Argentina., Eichel R; Department of Neurology (RE), Shaare Zedek Medical Center, Jerusalem, Israel; The School of Medicine (RE), The Hebrew University, Jerusalem, Israel. |
| المصدر: | The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry [Am J Geriatr Psychiatry] 2024 Sep; Vol. 32 (9), pp. 1063-1077. Date of Electronic Publication: 2024 Apr 10. |
| نوع المنشور: | Journal Article; Observational Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 9309609 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-7214 (Electronic) Linking ISSN: 10647481 NLM ISO Abbreviation: Am J Geriatr Psychiatry Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 2013- : London : Elsevier Original Publication: Washington, DC : American Psychiatry Press |
| مواضيع طبية MeSH: | Lewy Body Disease*/epidemiology , Lewy Body Disease*/complications , Attention Deficit Disorder with Hyperactivity*/epidemiology , Cognitive Dysfunction*/epidemiology , Cognitive Dysfunction*/etiology, Humans ; Female ; Male ; Prospective Studies ; Follow-Up Studies ; Aged ; Middle Aged ; Risk Factors ; Adult ; Incidence |
| مستخلص: | Objectives: Past reports have suggested that attention-deficit/hyperactivity disorder (ADHD) may be a risk factor for Lewy body disease (LBD). To confirm this relationship, we conducted the present study. Design: A prospective observational cohort study with a follow-up to 15 years. Setting: The subjects were recruited from cognitive neurology clinics, where they attended for a cognitive complaint or health check-up. Participants: Two groups of subjects: ADHD adults and healthy subjects. Measurements: The risk of dementia and LBD was estimated with Kaplan-Meier analysis comparing for the presence or absence of ADHD with the log-rank test. Predictors of conversion were assessed through separate univariate and multivariate Cox regression analyses, adjusting for several variables. Results: The baseline sample consisted of 161 subjects with ADHD and 109 without ADHD. At the end of the follow-up, 31 subjects developed dementia, 27 cases in the ADHD group and 4 in comparison group. Dementia with Lewy bodies (DLB) was the most frequent type (N:20) of which 19 corresponded to the ADHD group. The incidence of non-amnestic-MCI in the ADHD group was higher representing 67.1 % of these subjects (N:108), and 17.4% (N:19) of healthy cases. The hazard ratios for dementia and LBD in the multivariate adjusted model were 3.33 (95% CI 1.0915 to 10.1699) and 54.54 (95% CI 7.4849 to 397.5028), respectively in the ADHD group. Conclusions: This study showed that adult ADHD is independently associated with an increased risk of LBD, dementia, and na-MCI. Future studies should clarify this relationship to develop preventive measures for these patients. Competing Interests: DISCLOSURE The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: ADHD; Lewy body disease; cognitive decline and ADHD; dementia; mild cognitive impairment |
| تواريخ الأحداث: | Date Created: 20240502 Date Completed: 20240809 Latest Revision: 20240809 |
| رمز التحديث: | 20240812 |
| DOI: | 10.1016/j.jagp.2024.04.005 |
| PMID: | 38697886 |
| قاعدة البيانات: | MEDLINE |
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