دورية أكاديمية
Strategies to reprogram anti-inflammatory macrophages towards pro-inflammatory macrophages to support cancer immunotherapies.
| العنوان: | Strategies to reprogram anti-inflammatory macrophages towards pro-inflammatory macrophages to support cancer immunotherapies. |
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| المؤلفون: | Vizcaino Castro A; Laboratory of Tumor Virology and Cancer Immunotherapy, Department of Medical Microbiology and Infection Prevention, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Daemen T; Laboratory of Tumor Virology and Cancer Immunotherapy, Department of Medical Microbiology and Infection Prevention, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address: c.a.h.h.daemen@umcg.nl., Oyarce C; Laboratory of Tumor Virology and Cancer Immunotherapy, Department of Medical Microbiology and Infection Prevention, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. |
| المصدر: | Immunology letters [Immunol Lett] 2024 Jun; Vol. 267, pp. 106864. Date of Electronic Publication: 2024 May 03. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7910006 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0542 (Electronic) Linking ISSN: 01652478 NLM ISO Abbreviation: Immunol Lett Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press. |
| مواضيع طبية MeSH: | Neoplasms*/therapy , Neoplasms*/immunology , Immunotherapy*/methods , Tumor-Associated Macrophages*/immunology , Tumor-Associated Macrophages*/metabolism , Tumor Microenvironment*/immunology, Humans ; Animals ; Macrophages/immunology ; Macrophages/metabolism ; Cellular Reprogramming/immunology ; Macrophage Activation/immunology |
| مستخلص: | Tumor-associated myeloid cells, including macrophages and myeloid-derived suppressor cells, can be highly prevalent in solid tumors and play a significant role in the development of the tumor. Therefore, myeloid cells are being considered potential targets for cancer immunotherapies. In this review, we focused on strategies aimed at targeting tumor-associated macrophages (TAMs). Most strategies were studied preclinically but we also included a limited number of clinical studies based on these strategies. We describe possible underlying mechanisms and discuss future challenges and prospects. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Cancer immunotherapies; Polarization; Reprogramming; Tumor microenvironment; Tumor-associated macrophages |
| تواريخ الأحداث: | Date Created: 20240505 Date Completed: 20240529 Latest Revision: 20240702 |
| رمز التحديث: | 20240703 |
| DOI: | 10.1016/j.imlet.2024.106864 |
| PMID: | 38705481 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1879-0542 |
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| DOI: | 10.1016/j.imlet.2024.106864 |