دورية أكاديمية

Hemodynamic gain index and risk of chronic kidney disease: A prospective cohort study of middle-aged and older men.

التفاصيل البيبلوغرافية
العنوان: Hemodynamic gain index and risk of chronic kidney disease: A prospective cohort study of middle-aged and older men.
المؤلفون: Kunutsor SK; Diabetes Research Centre, University of Leicester, Leicester General Hospital, Gwendolen Road, Leicester, LE5 4WP, UK. skk31@cantab.net., Laukkanen JA; Institute of Clinical Medicine, Department of Medicine, University of Eastern Finland, Kuopio, Finland.; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.; Department of Medicine, Wellbeing Services County of Central Finland, Jyväskylä, Finland.
المصدر: GeroScience [Geroscience] 2024 Oct; Vol. 46 (5), pp. 5211-5215. Date of Electronic Publication: 2024 May 06.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cham : Springer International Publishing, [2017]-
مواضيع طبية MeSH: Renal Insufficiency, Chronic*/physiopathology , Renal Insufficiency, Chronic*/epidemiology , Blood Pressure*/physiology , Hemodynamics*/physiology, Humans ; Male ; Middle Aged ; Prospective Studies ; Adult ; Risk Assessment ; Heart Rate/physiology ; Risk Factors ; Exercise Test/methods
مستخلص: The hemodynamic gain index (HGI), a novel non-invasive hemodynamic marker, represents a promising advancement in cardiovascular risk assessment. Cardiovascular disease and chronic kidney disease (CKD) are closely intertwined and share bidirectional relationships. We aimed to assess the association of HGI with CKD risk in a prospective study. Hemodynamic gain index was calculated using heart rate and systolic blood pressure (SBP) responses measured in 1765 men aged 42-61 years with normal kidney function during exercise testing using the formula: [(Heart rate max x SBP max )-(Heart rate rest x SBP rest )]/(Heart rate rest x SBP rest ). Multivariable adjusted hazard ratios (HRs) (95% confidence intervals, CIs) were estimated for CKD. Over a median follow-up duration of 25.9 years, 175 CKD cases occurred. In analysis adjusted for established risk factors, a unit (bpm/mmHg) higher HGI was associated with a decreased risk of CKD (HR 0.78, 95% CI 0.65-0.95). Comparing extreme tertiles of HGI, the corresponding adjusted HR (95% CI) for CKD was 0.53 (0.33-0.85). Addition of HGI to a CKD risk prediction model containing established risk factors improved risk discrimination and reclassification (p-value for difference in -2 log likelihood = .011; net-reclassification-improvement = 59.37%, p = .018; integrated-discrimination-improvement = 0.0064, p = .008). Higher HGI is associated with a lower CKD risk and improves the prediction and classification of CKD beyond common established risk factors.
(© 2024. The Author(s).)
References: Stat Med. 2008 Jan 30;27(2):157-72; discussion 207-12. (PMID: 17569110)
Stat Med. 1996 Feb 28;15(4):361-87. (PMID: 8668867)
J Cardiopulm Rehabil Prev. 2023 May 1;43(3):222-224. (PMID: 36727902)
Cardiology. 2023;148(3):246-256. (PMID: 37054689)
Circulation. 2016 Dec 13;134(24):e653-e699. (PMID: 27881567)
J Cardiopulm Rehabil Prev. 2023 Sep 1;43(5):368-376. (PMID: 36867712)
Stat Med. 2011 Jan 15;30(1):11-21. (PMID: 21204120)
Am J Cardiol. 2019 Aug 15;124(4):644-649. (PMID: 31196561)
Contrib Nephrol. 2021;199:43-55. (PMID: 34343989)
Geroscience. 2023 Jun;45(3):1761-1774. (PMID: 36646903)
Int J Cardiol. 2020 Jun 1;308:15-19. (PMID: 32248965)
Am J Kidney Dis. 2002 Feb;39(2 Suppl 1):S1-266. (PMID: 11904577)
Kidney Int. 2011 Dec;80(12):1258-70. (PMID: 21993585)
Circulation. 2016 Jun 14;133(24):e694-711. (PMID: 27143685)
فهرسة مساهمة: Keywords: Chronic kidney disease; Cohort study; Exercise testing; Hemodynamic gain index
تواريخ الأحداث: Date Created: 20240505 Date Completed: 20240820 Latest Revision: 20240823
رمز التحديث: 20240823
مُعرف محوري في PubMed: PMC11335700
DOI: 10.1007/s11357-024-01184-2
PMID: 38705965
قاعدة البيانات: MEDLINE
الوصف
تدمد:2509-2723
DOI:10.1007/s11357-024-01184-2