دورية أكاديمية
Microglia and macrophages in glioblastoma: landscapes and treatment directions.
العنوان: | Microglia and macrophages in glioblastoma: landscapes and treatment directions. |
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المؤلفون: | Solomou G; Wellcome MRC Cambridge Stem Cell Institute, University of Cambridge, UK.; Department of Neurosurgery, Addenbrooke's Hospital, Cambridge, UK., Young AMH; Wellcome MRC Cambridge Stem Cell Institute, University of Cambridge, UK.; Department of Neurosurgery, Addenbrooke's Hospital, Cambridge, UK., Bulstrode HJCJ; Wellcome MRC Cambridge Stem Cell Institute, University of Cambridge, UK.; Department of Neurosurgery, Addenbrooke's Hospital, Cambridge, UK. |
المصدر: | Molecular oncology [Mol Oncol] 2024 May 07. Date of Electronic Publication: 2024 May 07. |
Publication Model: | Ahead of Print |
نوع المنشور: | Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: John Wiley & Sons, Inc Country of Publication: United States NLM ID: 101308230 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-0261 (Electronic) Linking ISSN: 15747891 NLM ISO Abbreviation: Mol Oncol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2017- : Hoboken, New Jersey : John Wiley & Sons, Inc. Original Publication: Amsterdam : Elsevier |
مستخلص: | Glioblastoma is the most common primary malignant tumour of the central nervous system and remains uniformly and rapidly fatal. The tumour-associated macrophage (TAM) compartment comprises brain-resident microglia and bone marrow-derived macrophages (BMDMs) recruited from the periphery. Immune-suppressive and tumour-supportive TAM cell states predominate in glioblastoma, and immunotherapies, which have achieved striking success in other solid tumours have consistently failed to improve survival in this 'immune-cold' niche context. Hypoxic and necrotic regions in the tumour core are found to enrich, especially in anti-inflammatory and immune-suppressive TAM cell states. Microglia predominate at the invasive tumour margin and express pro-inflammatory and interferon TAM cell signatures. Depletion of TAMs, or repolarisation towards a pro-inflammatory state, are appealing therapeutic strategies and will depend on effective understanding and classification of TAM cell ontogeny and state based on new single-cell and spatial multi-omic in situ profiling. Here, we explore the application of these datasets to expand and refine TAM characterisation, to inform improved modelling approaches, and ultimately underpin the effective manipulation of function. (© 2024 The Authors. Molecular Oncology published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.) |
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فهرسة مساهمة: | Keywords: glioblastoma; glioma; immune; macrophages; microenvironment; microglia |
تواريخ الأحداث: | Date Created: 20240507 Latest Revision: 20240507 |
رمز التحديث: | 20240507 |
DOI: | 10.1002/1878-0261.13657 |
PMID: | 38712663 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1878-0261 |
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DOI: | 10.1002/1878-0261.13657 |