دورية أكاديمية
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Agar-tragacanth/silk fibroin hydrogel containing Zn-based MOF as a novel nanobiocomposite with biological activity.

التفاصيل البيبلوغرافية
العنوان: Agar-tragacanth/silk fibroin hydrogel containing Zn-based MOF as a novel nanobiocomposite with biological activity.
المؤلفون: Lalebeigi F; Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran., Kashtiaray A; Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran., Aghamirza Moghim Aliabadi H; Medical Biotechnology Department, Biotechnology Research Center (BRC), Pasteur Institute of Iran (IPI), Tehran, Iran., Moghadaskhou F; Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran., Pajoum Z; Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran., Nokandeh SM; Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran., Mahdavi M; Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran., Eivazzadeh-Keihan R; Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran. reza.tab_chemist@yahoo.com., Maleki A; Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran. maleki@iust.ac.ir.
المصدر: Scientific reports [Sci Rep] 2024 May 07; Vol. 14 (1), pp. 10508. Date of Electronic Publication: 2024 May 07.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Fibroins*/chemistry , Hydrogels*/chemistry , Agar*/chemistry , Nanocomposites*/chemistry , Tragacanth*/chemistry, Humans ; Escherichia coli/drug effects ; Escherichia coli/growth & development ; Staphylococcus aureus/drug effects ; HEK293 Cells ; Zinc/chemistry ; Cell Proliferation/drug effects ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Metal-Organic Frameworks/chemistry ; Metal-Organic Frameworks/pharmacology ; Microbial Sensitivity Tests ; MCF-7 Cells ; Cell Line, Tumor
مستخلص: In this study, a novel nanobiocomposite consisting of agar (Ag), tragacanth gum (TG), silk fibroin (SF), and MOF-5 was synthesized and extensively investigated by various analytical techniques and basic biological assays for potential biomedical applications. The performed Trypan blue dye exclusion assay indicated that the proliferation percentage of HEK293T cells was 71.19%, while the proliferation of cancer cells (K-562 and MCF-7) was significantly lower, at 10.74% and 3.33%. Furthermore, the Ag-TG hydrogel/SF/MOF-5 nanobiocomposite exhibited significant antimicrobial activity against both E. coli and S. aureus strains, with growth inhibition rates of 76.08% and 69.19% respectively. Additionally, the hemolytic index of fabricated nanobiocomposite was found approximately 19%. These findings suggest that the nanobiocomposite exhibits significant potential for application in cancer therapy and wound healing.
(© 2024. The Author(s).)
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فهرسة مساهمة: Keywords: Agar; Biological activity; MOF-5; Silk fibroin; Tragacanth gum
المشرفين على المادة: 9007-76-5 (Fibroins)
0 (Hydrogels)
9002-18-0 (Agar)
9000-65-1 (Tragacanth)
J41CSQ7QDS (Zinc)
0 (Anti-Bacterial Agents)
0 (Metal-Organic Frameworks)
تواريخ الأحداث: Date Created: 20240507 Date Completed: 20240507 Latest Revision: 20240510
رمز التحديث: 20240510
مُعرف محوري في PubMed: PMC11076289
DOI: 10.1038/s41598-024-61329-3
PMID: 38714808
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-024-61329-3