دورية أكاديمية
أعرض في EDS

Prevalence of multi-drug resistant bacteria in intensive care units at Tripoli University Hospital, Tripoli, Libya.

التفاصيل البيبلوغرافية
العنوان: Prevalence of multi-drug resistant bacteria in intensive care units at Tripoli University Hospital, Tripoli, Libya.
المؤلفون: Ibrahim K; Department of Microbiology, Libyan Biotechnology Research Center, Tripoli, Libya., Thwood D; Department of Microbiology, Libyan Biotechnology Research Center, Tripoli, Libya., ELgheriani H; Department of Microbiology, Libyan Biotechnology Research Center, Tripoli, Libya., Salem M; Department of Microbiology, Libyan Biotechnology Research Center, Tripoli, Libya., Elgadiym Z; Department of Microbiology, Libyan Biotechnology Research Center, Tripoli, Libya., Zaghdani A; Department of Microbiology, Libyan Biotechnology Research Center, Tripoli, Libya., Alhudiri I; Department of Microbiology, Libyan Biotechnology Research Center, Tripoli, Libya., Habibi A; Department of Microbiology, Libyan Biotechnology Research Center, Tripoli, Libya., Elfahem A; Department of Microbiology, Libyan Biotechnology Research Center, Tripoli, Libya., Belaid S; Department of Microbiology, Libyan Biotechnology Research Center, Tripoli, Libya., Ermithi O; Department of Microbiology, Libyan Biotechnology Research Center, Tripoli, Libya., Almaghrabi M; Pediatric Intensive Care Unit, Tripoli University Hospital, Tripoli, Libya., ELmaryul A; Medical Intensive Care Unit, Tripoli University Hospital, Tripoli, Libya., Almadah S; Neonatal Intensive Care Unit, Tripoli University Hospital, Tripoli, Libya., Rayes A; Infection Control Office, Tripoli University Hospital, Tripoli, Libya., El Meshri SE; Department of Microbiology, Libyan Biotechnology Research Center, Tripoli, Libya., El Salabi A; Department of Environmental Health, Faculty of Public Health, University of Benghazi, Benghazi, Libya., Elzagheid A; Department of Microbiology, Libyan Biotechnology Research Center, Tripoli, Libya.
المصدر: The Libyan journal of medicine [Libyan J Med] 2024 Dec 31; Vol. 19 (1), pp. 2348235. Date of Electronic Publication: 2024 May 08.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101299403 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1819-6357 (Electronic) Linking ISSN: 18196357 NLM ISO Abbreviation: Libyan J Med Subsets: MEDLINE
أسماء مطبوعة: Publication: <2016- > : Philadelphia, PA : Taylor & Francis
Original Publication: [Libya] : Ibnosina Medical Association
مواضيع طبية MeSH: Intensive Care Units* , Drug Resistance, Multiple, Bacterial* , Hospitals, University*, Humans ; Libya/epidemiology ; Cross-Sectional Studies ; Prevalence ; Prospective Studies ; Male ; Female ; Anti-Bacterial Agents/pharmacology ; Microbial Sensitivity Tests ; Adult ; Gram-Negative Bacteria/isolation & purification ; Gram-Negative Bacteria/drug effects ; Cross Infection/epidemiology ; Cross Infection/microbiology ; Gram-Positive Bacteria/isolation & purification ; Gram-Positive Bacteria/drug effects ; Middle Aged
مستخلص: Among hospitalized patients worldwide, infections caused by multidrug-resistant (MDR) bacteria are a major cause of morbidity and mortality. This study aimed to isolate MDR bacteria from five intensive care units (ICUs) at Tripoli University Hospital (TUH). A prospective cross-sectional study was conducted over a seven-month period (September 2022 to March 2023) across five ICUs at TUH. A total of 197 swabs were collected from Patients', healthcare workers' and ICUs equipment. Samples collected from patients were nasal swabs, oral cavity swabs, hand swabs, sputum specimens, skin swabs, umbilical venous catheter swabs, and around cannula. Swabs collected from health care workers were nasal swabs, whereas ICUs equipment's samples were from endotracheal tubes, oxygen masks, and neonatal incubators. Identification and antimicrobial susceptibility test was confirmed by using MicroScan auto SCAN 4 (Beckman Coulter). The most frequent strains were Gram negative bacilli 113 (57.4%) with the predominance of Acinetobacter baumannii 50/113 (44%) followed by Klebsiella pneumoniae 44/113 (40%) and Pseudomonas aeruginosa 6/113 (5.3%). The total Gram positive bacterial strains isolated were 84 (42.6%), coagulase negative Staphylococci 55 (66%) with MDRs (89%) were the most common isolates followed by Staphylococcus aureus 15 (17.8%). Different antibiotics were used against these isolates; Gram- negative isolates showed high resistance rates to ceftazidime, gentamicin, amikacin and ertapenem. A. baumannii were the most frequent MDROs (94%), and the highest resistance rates in Gram-positive strains were observed toward ampicillin, oxacillin, ampicillin/sulbactam and Cefoxitin, representing 90% of total MDR Gram-positive isolates. ESBL and MRS were identified in most of strains. The prevalence of antibiotic resistance was high for both Gram negative and Gram positive isolates. This prevalence requires strict infection prevention and control intervention, continuous monitoring, implementation of effective antibiotic stewardship, immediate, concerted and collaborative action to monitor its prevalence and spread in the hospital.
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فهرسة مساهمة: Keywords: ICU; Libya; Multi-drug resistance; Tripoli University Hospital; antimicrobial susceptibility
المشرفين على المادة: 0 (Anti-Bacterial Agents)
تواريخ الأحداث: Date Created: 20240508 Date Completed: 20240508 Latest Revision: 20240511
رمز التحديث: 20240511
مُعرف محوري في PubMed: PMC11080667
DOI: 10.1080/19932820.2024.2348235
PMID: 38718270
قاعدة البيانات: MEDLINE
الوصف
تدمد:1819-6357
DOI:10.1080/19932820.2024.2348235