دورية أكاديمية
أعرض في EDS

Magnesium whitlockite nanoparticles: Hydrothermal synthesis, anti-inflammatory and anti-cancer potential.

التفاصيل البيبلوغرافية
العنوان: Magnesium whitlockite nanoparticles: Hydrothermal synthesis, anti-inflammatory and anti-cancer potential.
المؤلفون: Maximiano LV; Federal Institute of Education, Science, and Technology of Ceará, Campus Camocim, Camocim, CE 62400-000, Brazil., Correa LB; Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmaceuticals and Synthesis of Novel Radiopharmaceuticals, Rio de Janeiro 21941906, Brazil., Gomes-da-Silva NC; Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmaceuticals and Synthesis of Novel Radiopharmaceuticals, Rio de Janeiro 21941906, Brazil., da Costa LS; Institute of Chemistry, States University of Campinas (UNICAMP), Campinas, CP 13083-970, Brazil., Da Silva MGP; Federal Institute of Education, Science, and Technology of Ceará, Campus Camocim, Camocim, CE 62400-000, Brazil., Chaves AV; Group of Chemistry of Advanced Materials (GQMat), Department of Analytical Chemistry and Physic-chemistry, Federal University of Ceará, Campus do Pici, Fortaleza, CE 60451-970, Brazil., Franco ML; Group of Chemistry of Advanced Materials (GQMat), Department of Analytical Chemistry and Physic-chemistry, Federal University of Ceará, Campus do Pici, Fortaleza, CE 60451-970, Brazil., Fechine PBA; Group of Chemistry of Advanced Materials (GQMat), Department of Analytical Chemistry and Physic-chemistry, Federal University of Ceará, Campus do Pici, Fortaleza, CE 60451-970, Brazil., de Menezes AS; Department of Physics, Federal University of Maranhão, São Luís, MA CEP 65080-805, Brazil., Santos-Oliveira R; Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmaceuticals and Synthesis of Novel Radiopharmaceuticals, Rio de Janeiro 21941906, Brazil., Andrade Neto DM; Federal Institute of Education, Science, and Technology of Ceará, Campus Camocim, Camocim, CE 62400-000, Brazil; Group of Chemistry of Advanced Materials (GQMat), Department of Analytical Chemistry and Physic-chemistry, Federal University of Ceará, Campus do Pici, Fortaleza, CE 60451-970, Brazil. Electronic address: davino.machado@ifce.edu.br.
المصدر: Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2024 Jul; Vol. 239, pp. 113931. Date of Electronic Publication: 2024 Apr 25.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9315133 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4367 (Electronic) Linking ISSN: 09277765 NLM ISO Abbreviation: Colloids Surf B Biointerfaces Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam ; New York : Elsevier, c1993-
مواضيع طبية MeSH: Magnesium*/chemistry , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Anti-Inflammatory Agents*/pharmacology , Anti-Inflammatory Agents*/chemistry , Anti-Inflammatory Agents*/chemical synthesis , Cell Proliferation*/drug effects , Nanoparticles*/chemistry, Humans ; Cell Line, Tumor ; Animals ; Particle Size ; Interleukin-6/metabolism ; Mice ; Drug Screening Assays, Antitumor ; Tumor Necrosis Factor-alpha/metabolism ; Cell Survival/drug effects ; Surface Properties ; Nitric Oxide/metabolism ; Nitric Oxide/biosynthesis ; Calcium Phosphates
مستخلص: This study revealed the potential of magnesium whitlockite [WH: Ca 18 Mg 2 (HPO 4 ) 2 (PO 4 ) 12 ] nanoparticles (WH NPs) for anti-inflammatory and anti-cancer therapies. Although magnesium whitlockite possesses promising biological properties, its effects on inflammation and cancer remain unexplored. In this study, we address this gap by synthesizing WH NPs and demonstrating their multifaceted functionalities. Through detailed characterization, we revealed the synthesis pathway involving brushite as a precursor, with magnesium ions incorporated during hydrothermal treatment. WH NPs exhibited anti-inflammatory properties by significantly reducing the production of key inflammatory markers (NO, TNF-α, and IL-6). Furthermore, they display promising anti-cancer activity by inhibiting the proliferation of MDA-MB-231 breast cancer cells. Our findings not only establish a deeper understanding of WH NP synthesis but also highlight their potential for the development of innovative cancer and inflammatory treatments.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Anti-cancer properties; Anti-inflammatory properties; Hydrothermal approach; MDA-MB-231 breast cancer; Magnesium Whitlockite
المشرفين على المادة: I38ZP9992A (Magnesium)
0 (Antineoplastic Agents)
0 (Anti-Inflammatory Agents)
0 (Interleukin-6)
O7TSZ97GEP (calcium phosphate, dibasic, dihydrate)
0 (Tumor Necrosis Factor-alpha)
31C4KY9ESH (Nitric Oxide)
0 (Calcium Phosphates)
تواريخ الأحداث: Date Created: 20240508 Date Completed: 20240606 Latest Revision: 20240606
رمز التحديث: 20240607
DOI: 10.1016/j.colsurfb.2024.113931
PMID: 38718475
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-4367
DOI:10.1016/j.colsurfb.2024.113931