تقرير
أعرض في EDS

A Case Report of Refractory Graft-Versus-Host Disease Colitis Managed With Robotic Total Abdominal Colectomy.

التفاصيل البيبلوغرافية
العنوان: A Case Report of Refractory Graft-Versus-Host Disease Colitis Managed With Robotic Total Abdominal Colectomy.
المؤلفون: Ziegler O; General Surgery, Penn State Health Milton S. Hershey Medical Center, Hershey, USA., Jikaria NR; General Surgery, Penn State Health Milton S. Hershey Medical Center, Hershey, USA., Cioccio J; Hematology and Oncology, Penn State Cancer Institute, Hershey, USA., Scow JS; Colorectal Surgery, Penn State Health Milton S. Hershey Medical Center, Hershey, USA.
المصدر: Cureus [Cureus] 2024 Apr 08; Vol. 16 (4), pp. e57829. Date of Electronic Publication: 2024 Apr 08 (Print Publication: 2024).
نوع المنشور: Case Reports
اللغة: English
بيانات الدورية: Publisher: Cureus, Inc Country of Publication: United States NLM ID: 101596737 Publication Model: eCollection Cited Medium: Print ISSN: 2168-8184 (Print) Linking ISSN: 21688184 NLM ISO Abbreviation: Cureus Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Palo Alto, CA : Cureus, Inc.
مستخلص: Graft-versus-host disease (GvHD) is a common complication following hematopoietic stem cell transplant (HSCT) and has protean manifestations. It results from the activation of transplanted T lymphocytes against the HLA antigens of recipient cells, resulting in tissue destruction. The most commonly involved sites of acute GvHD are the skin and gut, with high mortality reported in the latter. Historically, surgery for gut GvHD has been reserved for those with frank perforations or uncontrolled hemorrhage. Here, we present a case of steroid and ruxolitinib refractory colonic GvHD in a 41-year-old female, which was ultimately managed with robotic-assisted total abdominal colectomy with resolution of enteric symptoms. This case highlights the role of surgical management in gut GvHD in patients who are refractory to the growing arsenal of immunomodulating agents. Given the rarity of surgical intervention in this population, more data are needed to minimize morbidity in this setting.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright © 2024, Ziegler et al.)
References: Biol Blood Marrow Transplant. 2016 Jan;22(1):11-6. (PMID: 26453971)
Biol Blood Marrow Transplant. 2016 Jan;22(1):4-10. (PMID: 26386318)
Bone Marrow Transplant. 2020 Mar;55(3):641-648. (PMID: 31700138)
Blood. 2014 Aug 14;124(7):1174-82. (PMID: 24939656)
Blood. 2014 Jul 17;124(3):374-84. (PMID: 24914139)
Ann Surg. 2021 Nov 1;274(5):773-779. (PMID: 34342300)
Gastroenterology. 1994 Nov;107(5):1398-407. (PMID: 7926504)
Biol Blood Marrow Transplant. 2002;8(7):387-94. (PMID: 12171485)
Ann Hematol. 2019 Oct;98(10):2407-2419. (PMID: 31338570)
Blood. 1992 Oct 1;80(7):1838-45. (PMID: 1391947)
Br J Haematol. 2012 Jul;158(1):30-45. (PMID: 22533831)
Dis Colon Rectum. 1998 Dec;41(12):1573-6. (PMID: 9860340)
Int J Colorectal Dis. 2021 Jun;36(6):1133-1145. (PMID: 33528750)
Dis Colon Rectum. 1993 Aug;36(8):757-62. (PMID: 8348866)
N Engl J Med. 2020 May 7;382(19):1800-1810. (PMID: 32320566)
Arch Surg. 2008 Nov;143(11):1041-5; discussion 1046. (PMID: 19015460)
Nat Rev Gastroenterol Hepatol. 2017 Dec;14(12):711-726. (PMID: 28951581)
Br J Haematol. 2021 Nov;195(3):429-432. (PMID: 34254289)
Biol Blood Marrow Transplant. 2015 Apr;21(4):761-7. (PMID: 25585275)
Int Surg. 2012 Jan-Mar;97(1):14-6. (PMID: 23101995)
فهرسة مساهمة: Keywords: acute graft-versus-host disease; allogeneic stem cell transplant recipients; colon and rectal surgery; gastrointestinal graft-versus-host disease; total abdominal colectomy
تواريخ الأحداث: Date Created: 20240509 Latest Revision: 20240510
رمز التحديث: 20240510
مُعرف محوري في PubMed: PMC11077475
DOI: 10.7759/cureus.57829
PMID: 38721168
قاعدة البيانات: MEDLINE
الوصف
تدمد:2168-8184
DOI:10.7759/cureus.57829