دورية أكاديمية
Men with metastatic prostate cancer carrying a pathogenic germline variant in breast cancer genes: disclosure of genetic test results to relatives.
العنوان: | Men with metastatic prostate cancer carrying a pathogenic germline variant in breast cancer genes: disclosure of genetic test results to relatives. |
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المؤلفون: | Vlaming M; Department of Genetics, Division Laboratories, Pharmacy and Biomedical Genetics, University Medical Center Utrecht, Heidelberglaan 100, CX Utrecht, 3584, The Netherlands., Ausems MGEM; Department of Genetics, Division Laboratories, Pharmacy and Biomedical Genetics, University Medical Center Utrecht, Heidelberglaan 100, CX Utrecht, 3584, The Netherlands., Schijven G; Department of Genetics, Division Laboratories, Pharmacy and Biomedical Genetics, University Medical Center Utrecht, Heidelberglaan 100, CX Utrecht, 3584, The Netherlands., van Oort IM; Department of Urology, Radboud University Medical Center, Geert Grooteplein Zuid 10, GA Nijmegen, 6525, The Netherlands., Kets CM; Department of Human Genetics, Radboud University Medical Center, Geert Grooteplein Zuid 10, GA Nijmegen, 6525, The Netherlands., Komdeur FL; Department of Human Genetics, Amsterdam University Medical Centers, Meibergdreef 9, AZ Amsterdam, 1105, The Netherlands., van der Kolk LE; Department of Clinical Genetics, the Netherlands Cancer Institute, Plesmanlaan 121, CX Amsterdam, 1066, The Netherlands., Oldenburg RA; Department of Clinical Genetics, Erasmus Medical Center, Dr. Molewaterplein 40, GD Rotterdam, 3015, The Netherlands., Sijmons RH; Department of Genetics, University Medical Center Groningen, Hanzeplein 1, GZ Groningen, 9713, The Netherlands., Kiemeney LALM; Department of Urology, Radboud University Medical Center, Geert Grooteplein Zuid 10, GA Nijmegen, 6525, The Netherlands.; Department for Health Evidence, Radboud University Medical Center, Geert Grooteplein Zuid 10, GA Nijmegen, 6525, The Netherlands., Bleiker EMA; Department of Clinical Genetics, the Netherlands Cancer Institute, Plesmanlaan 121, CX Amsterdam, 1066, The Netherlands. e.m.a.bleiker@lumc.nl.; Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute, Plesmanlaan 121, CX Amsterdam, 1066, The Netherlands. e.m.a.bleiker@lumc.nl.; Department of Clinical Genetics, Leiden University Medical Center, Albinusdreef 2, ZA Leiden, 2333, The Netherlands. e.m.a.bleiker@lumc.nl. |
المصدر: | Familial cancer [Fam Cancer] 2024 Jun; Vol. 23 (2), pp. 165-175. Date of Electronic Publication: 2024 May 09. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Springer Country of Publication: Netherlands NLM ID: 100898211 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7292 (Electronic) Linking ISSN: 13899600 NLM ISO Abbreviation: Fam Cancer Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Dordrecht : Springer Original Publication: Dordrecht ; Boston : Kluwer Academic Publishers, c2001- |
مواضيع طبية MeSH: | Prostatic Neoplasms*/genetics , Prostatic Neoplasms*/psychology , Prostatic Neoplasms*/pathology , Genetic Testing* , Germ-Line Mutation* , Genetic Predisposition to Disease*/psychology, Humans ; Male ; Middle Aged ; Aged ; BRCA2 Protein/genetics ; Disclosure ; Fanconi Anemia Complementation Group N Protein/genetics ; BRCA1 Protein/genetics ; Checkpoint Kinase 2/genetics ; Breast Neoplasms/genetics ; Breast Neoplasms/psychology ; Breast Neoplasms/pathology ; Family/psychology ; Female ; Ataxia Telangiectasia Mutated Proteins/genetics ; Adult |
مستخلص: | Some patients with metastatic prostate cancer carry a pathogenic germline variant (PV) in a gene, that is mainly associated with an increased risk of breast cancer in women. If they test positive for such a PV, prostate cancer patients are encouraged to disclose the genetic test result to relatives who are at risk in case the carrier status changes the relatives' medical care. Our study aimed to investigate how men who learned they carry a PV in BRCA1, BRCA2, PALB2, CHEK2 or ATM disclosed their carrier status to at-risk relatives and to assess the possible psychological burden for the carrier and their perception of the burden for relatives. In total, 23 men with metastatic prostate cancer carrying a PV completed the IRI questionnaire about family communication; 14 also participated in a semi-structured interview. Patients felt highly confident in discussing the genetic test result with relatives. The diagnosis of prostate cancer was experienced as a burden, whereas being informed about genetic testing results did in most cases not add to this burden. Two patients encountered negative experiences with family communication, as they considered the genetic test result to be more urgent than their relatives. This mixed-methods study shows that metastatic prostate cancer patients with a PV in genes mainly associated with increased risk of breast cancer feel well-equipped to communicate about this predisposition in their families. Carriers felt motivated to disclose their genetic test result to relatives. Most of them indicated that the disclosure was not experienced as a psychological burden. (© 2024. The Author(s).) |
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معلومات مُعتمدة: | 12601 KWF Kankerbestrijding |
فهرسة مساهمة: | Keywords: Breast cancer; Family communication; Genetic testing; Metastatic prostate cancer; Psychosocial |
المشرفين على المادة: | 0 (BRCA2 Protein) 0 (PALB2 protein, human) 0 (BRCA2 protein, human) 0 (Fanconi Anemia Complementation Group N Protein) 0 (BRCA1 Protein) 0 (BRCA1 protein, human) EC 2.7.11.1 (CHEK2 protein, human) EC 2.7.1.11 (Checkpoint Kinase 2) EC 2.7.11.1 (ATM protein, human) EC 2.7.11.1 (Ataxia Telangiectasia Mutated Proteins) |
تواريخ الأحداث: | Date Created: 20240509 Date Completed: 20240605 Latest Revision: 20240709 |
رمز التحديث: | 20240710 |
مُعرف محوري في PubMed: | PMC11153271 |
DOI: | 10.1007/s10689-024-00377-0 |
PMID: | 38722431 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1573-7292 |
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DOI: | 10.1007/s10689-024-00377-0 |