دورية أكاديمية
Cutaneous Superficial Basal Cell Carcinoma is a Basal Cell Carcinoma In Situ: Electron Microscopy of a Case Series of Basal Cell Carcinomas.
| العنوان: | Cutaneous Superficial Basal Cell Carcinoma is a Basal Cell Carcinoma In Situ: Electron Microscopy of a Case Series of Basal Cell Carcinomas. |
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| المؤلفون: | Kaur H; Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY, USA. Harsimran_Kaur@urmc.Rochester.edu., de Mesy Bentley KL; Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY, USA., Rahman SM; School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY, USA., Cohen PR; Department of Dermatology, Davis Medical Center, University of California, Sacramento, CA, USA.; Touro University California College of Osteopathic Medicine, Vallejo, CA, USA., Smoller BR; Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY, USA. Bruce_Smoller@urmc.Rochester.edu.; Department of Dermatology, University of Rochester Medical Center, Rochester, NY, USA. Bruce_Smoller@urmc.Rochester.edu. |
| المصدر: | Dermatology and therapy [Dermatol Ther (Heidelb)] 2024 May; Vol. 14 (5), pp. 1359-1366. Date of Electronic Publication: 2024 May 09. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Healthcare Communications Country of Publication: Switzerland NLM ID: 101590450 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2193-8210 (Print) NLM ISO Abbreviation: Dermatol Ther (Heidelb) Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: Switzerland : Springer Healthcare Communications Original Publication: Heidelberg : Springer 2011- |
| مستخلص: | Basal cell carcinoma (BCC) is the most common skin cancer. Skin cancers may present either as a non-invasive tumor or an invasive malignancy. The terminology of carcinoma in situ is used when the tumor is either just limited to epidermis or not present as single cells or nests in the dermis. However, currently the terminology superficial BCC is inappropriately used instead of BCC in situ when the skin cancer is limited to epidermis. In this study we compare the pathologic changes of superficial, nodular, and infiltrative BCCs using electron microscopy to identify the ultrastructural characteristics and validate the previously proposed terminology. Three cases of BCC (superficial BCC, nodular BCC, and infiltrative BCC) diagnosed by dermatopathologists at our institute were selected for review. Paraffin block tissues from these cases were sent for electron microscopy studies which demonstrated disruption of basal lamina in both nodular and infiltrative type of BCC, while it remains intact in BCC superficial type after extensive examination. Therefore, similar to other in situ skin cancers, there is no invasion of the neoplasm in superficial BCC into the dermis. Hence, the older term superficial BCC should be appropriately replaced with the newer terminology BCC in situ. (© 2024. The Author(s).) |
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| فهرسة مساهمة: | Keywords: Basal cell carcinoma; Basal lamina; Carcinoma; Electron microscopy; In situ; Skin cancer; Superficial; Ultrastructure |
| تواريخ الأحداث: | Date Created: 20240509 Latest Revision: 20240526 |
| رمز التحديث: | 20240526 |
| مُعرف محوري في PubMed: | PMC11116291 |
| DOI: | 10.1007/s13555-024-01151-x |
| PMID: | 38722558 |
| قاعدة البيانات: | MEDLINE |
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