دورية أكاديمية
أعرض في EDS

Null T-cell phenotype mycosis fungoides with aberrant CD20 and CD56 expression: A diagnostic dilemma.

التفاصيل البيبلوغرافية
العنوان: Null T-cell phenotype mycosis fungoides with aberrant CD20 and CD56 expression: A diagnostic dilemma.
المؤلفون: Aran BM; University of Virginia School of Medicine, Charlottesville, Virginia, USA., Burton R; Department of Pathology, University of Virginia, Charlottesville, Virginia, USA., High WA; Department of Pathology, University of Colorado, Denver, Colorado, USA., Gru AA; Department of Dermatology, Columbia University, New York, New York, USA.
المصدر: Journal of cutaneous pathology [J Cutan Pathol] 2024 Aug; Vol. 51 (8), pp. 614-617. Date of Electronic Publication: 2024 May 09.
نوع المنشور: Case Reports; Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 0425124 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0560 (Electronic) Linking ISSN: 03036987 NLM ISO Abbreviation: J Cutan Pathol Subsets: MEDLINE
أسماء مطبوعة: Publication: Malden, MA : Wiley
Original Publication: Copenhagen, Blackwell Munksgaard.
مواضيع طبية MeSH: Mycosis Fungoides*/pathology , Mycosis Fungoides*/diagnosis , Mycosis Fungoides*/metabolism , CD56 Antigen*/metabolism , Skin Neoplasms*/pathology , Skin Neoplasms*/diagnosis , Skin Neoplasms*/metabolism , Antigens, CD20*/metabolism, Humans ; Male ; Middle Aged ; Immunophenotyping/methods ; Phenotype ; T-Lymphocytes/pathology ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; Diagnosis, Differential ; Biomarkers, Tumor/metabolism
مستخلص: Mycosis fungoides (MF) represents the most common type of primary cutaneous T-cell lymphoma. Recognition of MF variants with divergent immunophenotypes is important for accurate diagnosis and appropriate management, as they can be confused with other lymphoma subtypes. We present a case of a 49-year-old male previously diagnosed with a cutaneous lymphoproliferative disorder with an unusual NK/T-cell phenotype. He presented with a 10-year history of pelvic girdle rash involving the right hip and upper thigh. The lesions were characterized as atrophic patches concentrated in sun-protected areas and involving 10% of the body surface area. Shave biopsies revealed an atypical epidermotropic infiltrate composed of hyperchromatic small to medium-sized lymphocytes with perinuclear halos and "tagging" along the dermal-epidermal junction. The immunophenotype was unusual in that the neoplastic lymphocytes showed complete loss of pan T-cell antigens along with expression of CD56, cytotoxic markers, and weak CD20. All other B-cell markers were negative. The combination of clinical findings, in addition to the histopathologic and immunophenotypic profile, were diagnostic of null T-cell phenotype MF with aberrant expression of CD56 and CD20. Null T-cell phenotype MF is very uncommon, can be diagnostically challenging, and can mislead the diagnosis of aggressive lymphoma subtypes.
(© 2024 The Authors. Journal of Cutaneous Pathology published by John Wiley & Sons Ltd.)
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فهرسة مساهمة: Keywords: CD20; CD56; mycosis fungoides; null T‐cell
المشرفين على المادة: 0 (CD56 Antigen)
0 (Antigens, CD20)
0 (NCAM1 protein, human)
0 (Biomarkers, Tumor)
تواريخ الأحداث: Date Created: 20240510 Date Completed: 20240708 Latest Revision: 20240708
رمز التحديث: 20240708
DOI: 10.1111/cup.14643
PMID: 38725374
قاعدة البيانات: MEDLINE
الوصف
تدمد:1600-0560
DOI:10.1111/cup.14643