دورية أكاديمية
أعرض في EDS

Systemic correlates of cutaneous manifestations of lupus erythematosus.

التفاصيل البيبلوغرافية
العنوان: Systemic correlates of cutaneous manifestations of lupus erythematosus.
المؤلفون: Heil PM; Department of Dermatology, Medical University of Vienna, Vienna, Austria.; Visiting Research Fellow, Mayo Clinic, Rochester, MN, USA., Pittelkow MR; Department of Dermatology, Mayo Clinic, Scottsdale, AZ, USA., Weaver AL; Division of Clinical Trials and Biostatistics, Mayo Clinic, Rochester, MN, USA., Killian JM; Division of Clinical Trials and Biostatistics, Mayo Clinic, Rochester, MN, USA., Sokumbi O; Department of Dermatology, Mayo Clinic, Jacksonville, FL, USA., Wetter DA; Department of Dermatology, Mayo Clinic, Rochester, MN, USA.
المصدر: International journal of dermatology [Int J Dermatol] 2024 Aug; Vol. 63 (8), pp. e148-e156. Date of Electronic Publication: 2024 May 10.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Blackwell Science Country of Publication: England NLM ID: 0243704 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-4632 (Electronic) Linking ISSN: 00119059 NLM ISO Abbreviation: Int J Dermatol Subsets: MEDLINE
أسماء مطبوعة: Publication: Oxford : Blackwell Science
Original Publication: Philadelphia, Lippincott.
مواضيع طبية MeSH: Lupus Erythematosus, Systemic*/complications , Lupus Erythematosus, Systemic*/immunology , Lupus Erythematosus, Systemic*/blood , Lupus Erythematosus, Systemic*/epidemiology , Lupus Erythematosus, Cutaneous*/immunology , Lupus Erythematosus, Cutaneous*/blood , Lupus Erythematosus, Cutaneous*/epidemiology , Lupus Erythematosus, Cutaneous*/complications , Photosensitivity Disorders*/etiology , Photosensitivity Disorders*/epidemiology , Photosensitivity Disorders*/blood , Photosensitivity Disorders*/immunology , Antibodies, Antinuclear*/blood , Antibodies, Antinuclear*/immunology, Humans ; Female ; Male ; Adult ; Middle Aged ; Retrospective Studies ; C-Reactive Protein/analysis ; Prevalence ; Young Adult ; Severity of Illness Index ; Aged ; Ribonucleoprotein, U1 Small Nuclear/immunology
مستخلص: Background: We aimed to investigate the prevalence of skin disease among patients with systemic lupus erythematosus (SLE) and determine whether LE skin disease had clinical or serologic correlates with SLE.
Methods: We reviewed records of 335 patients with SLE (seen at Mayo Clinic, Rochester, Minnesota, USA) and abstracted skin manifestations, fulfilled mucocutaneous SLE criteria, and clinical and serologic parameters.
Results: Of the 231 patients with skin manifestations, 57 (24.7%) had LE-specific conditions, 102 (44.2%) had LE-nonspecific conditions, and 72 (31.2%) had both. LE skin disease was associated with photosensitivity, anti-Smith antibodies, and anti-U1RNP antibodies (all P < 0.001). Patients without LE skin disease more commonly had elevated C-reactive protein levels (P = 0.01). Patients meeting 2-4 mucocutaneous American College of Rheumatology criteria less commonly had cytopenia (P = 0.004) or anti-double-stranded DNA antibodies (P = 0.004). No significant associations were observed for systemic involvement (renal, hematologic, neurologic, and arthritis) when comparing patients with or without LE skin involvement. LE skin involvement was not significantly associated with internal SLE disease flare, number of medications, or overall survival.
Conclusions: LE skin disease commonly occurs in patients with SLE. The presence of LE skin disease had no mitigating impact on the severity of SLE sequelae, disease flares, number of medications, or overall survival.
(© 2024 Mayo Foundation for Medical Education and Research. International Journal of Dermatology published by Wiley Periodicals LLC on behalf of the International Society of Dermatology.)
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فهرسة مساهمة: Keywords: antinuclear antibody; autoimmune diseases; collagen vascular diseases; cutaneous lupus erythematosus; discoid lupus erythematosus; lupus; survival rates; systemic lupus erythematosus
المشرفين على المادة: 0 (Antibodies, Antinuclear)
9007-41-4 (C-Reactive Protein)
0 (Ribonucleoprotein, U1 Small Nuclear)
تواريخ الأحداث: Date Created: 20240510 Date Completed: 20240723 Latest Revision: 20240723
رمز التحديث: 20240723
DOI: 10.1111/ijd.17178
PMID: 38727096
قاعدة البيانات: MEDLINE
الوصف
تدمد:1365-4632
DOI:10.1111/ijd.17178