دورية أكاديمية
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Ficus platyphylla alleviates seizure severity and neurobehavioral comorbidities in pentylenetetrazole-kindled rats via modulation of oxidative stress.

التفاصيل البيبلوغرافية
العنوان: Ficus platyphylla alleviates seizure severity and neurobehavioral comorbidities in pentylenetetrazole-kindled rats via modulation of oxidative stress.
المؤلفون: Chindo BA; Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Kaduna State University, Kaduna, Nigeria. Electronic address: bachindo@kasu.edu.ng., Yakubu MI; Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Kaduna State University, Kaduna, Nigeria., Jimoh AA; Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Kaduna State University, Kaduna, Nigeria., Waziri PM; Department of Biochemistry, Faculty of Life Sciences, Kaduna State University, Kaduna, Nigeria., Abdullahi I; Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Kaduna State University, Kaduna, Nigeria., Ayuba GI; Department of Anatomic Pathology and Forensic Medicine, College of Medicine, Kaduna State University, Kaduna, Nigeria., Becker A; Institute of Pharmacology and Toxicology, Faculty of Medicine, Otto-von-Guericke University, Leipziger Str. 44, 39120 Magdeburg, Germany.
المصدر: Brain research [Brain Res] 2024 Sep 01; Vol. 1838, pp. 148994. Date of Electronic Publication: 2024 May 09.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 0045503 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-6240 (Electronic) Linking ISSN: 00068993 NLM ISO Abbreviation: Brain Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam Elsevier/North-Holland Biomedical Press.
مواضيع طبية MeSH: Ficus* , Oxidative Stress*/drug effects , Pentylenetetrazole* , Plant Extracts*/pharmacology , Plant Extracts*/therapeutic use , Kindling, Neurologic*/drug effects , Seizures*/drug therapy , Seizures*/metabolism , Seizures*/chemically induced , Anticonvulsants*/pharmacology, Animals ; Male ; Rats ; Rats, Wistar ; Disease Models, Animal ; Behavior, Animal/drug effects ; Epilepsy/drug therapy ; Epilepsy/chemically induced
مستخلص: PTZ kindling induces oxidative stress, neuronal cell degeneration, and neurobehavioral alterations in rodents that mimic neuropsychiatric comorbidities of epilepsy, which could be initiated or aggravated by some antiepileptic drugs. Here, we investigated the effects of the methanol extract of Ficus platyphylla (FP) on severity scores for seizures, neuronal cell degeneration, and neurobehavioral alterations in rats kindled with pentylenetetrazole (PTZ) and probed the involvement of oxidative stress in these ameliorative effects of FP. FP (50 and 100 mg/kg, p.o.) ameliorated seizure severity, neuronal cell degeneration, depressive behaviors, cognitive dysfunctions, and oxidative stress in rats kindled with PTZ (42.5 mg/kg, i.p.). The findings from this study give additional insights into the potential values of FP in the treatment of persistent epilepsy and major neuropsychiatric comorbidities via modulation of oxidative stress.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Cognitive dysfunction; Depression; Ficus platyphylla; Neuronal cell degeneration; Oxidative stress; PTZ–kindling
المشرفين على المادة: WM5Z385K7T (Pentylenetetrazole)
0 (Plant Extracts)
0 (Anticonvulsants)
تواريخ الأحداث: Date Created: 20240510 Date Completed: 20240614 Latest Revision: 20240614
رمز التحديث: 20240615
DOI: 10.1016/j.brainres.2024.148994
PMID: 38729331
قاعدة البيانات: MEDLINE
الوصف
تدمد:1872-6240
DOI:10.1016/j.brainres.2024.148994