دورية أكاديمية
أعرض في EDS

Cold Atmospheric Pressure Plasma-Activated Medium Modulates Cellular Functions of Human Mesenchymal Stem/Stromal Cells In Vitro.

التفاصيل البيبلوغرافية
العنوان: Cold Atmospheric Pressure Plasma-Activated Medium Modulates Cellular Functions of Human Mesenchymal Stem/Stromal Cells In Vitro.
المؤلفون: Hahn O; Institute of Cell Biology, Rostock University Medical Center, 18057 Rostock, Germany., Waheed TO; Institute of Cell Biology, Rostock University Medical Center, 18057 Rostock, Germany., Sridharan K; Institute of Cell Biology, Rostock University Medical Center, 18057 Rostock, Germany., Huemerlehner T; Institute of Cell Biology, Rostock University Medical Center, 18057 Rostock, Germany., Staehlke S; Institute of Cell Biology, Rostock University Medical Center, 18057 Rostock, Germany., Thürling M; Microfluidics, Faculty of Mechanical Engineering and Marine Technology, University of Rostock, 18059 Rostock, Germany., Boeckmann L; Clinic and Polyclinic for Dermatology and Venerology Rostock, Rostock University Medical Center, 18057 Rostock, Germany., Meister M; Leibniz-Institute for Plasma Science and Technology e.V., 17489 Greifswald, Germany., Masur K; Leibniz-Institute for Plasma Science and Technology e.V., 17489 Greifswald, Germany., Peters K; Institute of Cell Biology, Rostock University Medical Center, 18057 Rostock, Germany.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 May 01; Vol. 25 (9). Date of Electronic Publication: 2024 May 01.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Mesenchymal Stem Cells*/metabolism , Mesenchymal Stem Cells*/drug effects , Mesenchymal Stem Cells*/cytology , Plasma Gases*/pharmacology , Cell Movement*/drug effects , Reactive Oxygen Species*/metabolism , Culture Media*/chemistry , Culture Media*/pharmacology , Oxidative Stress*/drug effects , Atmospheric Pressure*, Humans ; Cells, Cultured ; Cell Survival/drug effects ; Cell Proliferation/drug effects
مستخلص: Cold atmospheric pressure plasma (CAP) offers a variety of therapeutic possibilities and induces the formation of reactive chemical species associated with oxidative stress. Mesenchymal stem/stromal cells (MSCs) play a central role in tissue regeneration, partly because of their antioxidant properties and ability to migrate into regenerating areas. During the therapeutic application, MSCs are directly exposed to the reactive species of CAP. Therefore, the investigation of CAP-induced effects on MSCs is essential. In this study, we quantified the amount of ROS due to the CAP activation of the culture medium. In addition, cell number, metabolic activity, stress signals, and migration were analyzed after the treatment of MSCs with a CAP-activated medium. CAP-activated media induced a significant increase in ROS but did not cause cytotoxic effects on MSCs when the treatment was singular and short-term (one day). This single treatment led to increased cell migration, an essential process in wound healing. In parallel, there was an increase in various cell stress proteins, indicating an adaptation to oxidative stress. Repeated treatments with the CAP-activated medium impaired the viability of the MSCs. The results shown here provide information on the influence of treatment frequency and intensity, which could be necessary for the therapeutic application of CAP.
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معلومات مُعتمدة: TBI-V-1-336-VBW-116 European Union and the Federal State Mecklenburg-Vorpommern, EFRE
فهرسة مساهمة: Keywords: cell migration; cold atmospheric pressure plasma; mesenchymal stem/stromal cells; metabolic activity; oxidative stress; plasma-activated medium
المشرفين على المادة: 0 (Plasma Gases)
0 (Reactive Oxygen Species)
0 (Culture Media)
تواريخ الأحداث: Date Created: 20240511 Date Completed: 20240511 Latest Revision: 20240513
رمز التحديث: 20240513
مُعرف محوري في PubMed: PMC11084445
DOI: 10.3390/ijms25094944
PMID: 38732164
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms25094944