دورية أكاديمية
Synthetic MRI and diffusion-weighted imaging for differentiating nasopharyngeal lymphoma from nasopharyngeal carcinoma: combination with morphological features.
| العنوان: | Synthetic MRI and diffusion-weighted imaging for differentiating nasopharyngeal lymphoma from nasopharyngeal carcinoma: combination with morphological features. |
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| المؤلفون: | Zhang H; Department of Radiology, Affiliated Hospital of Jiangnan University, Wuxi 214062, China., Hu L; Department of Otolaryngology-Head and Neck Surgery, Affiliated Hospital of Jiangnan University, Wuxi 214062, China., Qin F; Department of Radiology, Affiliated Hospital of Jiangnan University, Wuxi 214062, China., Chang J; Department of Radiology, Affiliated Hospital of Jiangnan University, Wuxi 214062, China., Zhong Y; Department of Radiology, Affiliated Hospital of Jiangnan University, Wuxi 214062, China., Dou W; GE Healthcare, MR Research China, Beijing, China., Hu S; Department of Radiology, Affiliated Hospital of Jiangnan University, Wuxi 214062, China., Wang P; Department of Radiology, Affiliated Hospital of Jiangnan University, Wuxi 214062, China. |
| المصدر: | The British journal of radiology [Br J Radiol] 2024 Jun 18; Vol. 97 (1159), pp. 1278-1285. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: British Institute of Radiology Country of Publication: England NLM ID: 0373125 Publication Model: Print Cited Medium: Internet ISSN: 1748-880X (Electronic) Linking ISSN: 00071285 NLM ISO Abbreviation: Br J Radiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London, British Institute of Radiology. |
| مواضيع طبية MeSH: | Diffusion Magnetic Resonance Imaging*/methods , Nasopharyngeal Carcinoma*/diagnostic imaging , Nasopharyngeal Carcinoma*/pathology , Nasopharyngeal Neoplasms*/diagnostic imaging , Nasopharyngeal Neoplasms*/pathology , Lymphoma*/diagnostic imaging , Sensitivity and Specificity*, Humans ; Male ; Female ; Middle Aged ; Diagnosis, Differential ; Retrospective Studies ; Adult ; Aged ; Feasibility Studies ; Magnetic Resonance Imaging/methods ; Young Adult |
| مستخلص: | Objectives: To investigate the feasibility of synthetic MRI (syMRI), diffusion-weighted imaging (DWI), and their combination with morphological features for differentiating nasopharyngeal lymphoma (NPL) from nasopharyngeal carcinoma (NPC). Methods: Sixty-nine patients with nasopharyngeal tumours (NPL, n = 22; NPC, n = 47) who underwent syMRI and DWI were retrospectively enrolled between October 2020 and May 2022. syMRI and DWI quantitative parameters (T1, T2, PD, ADC) and morphological features were obtained. Diagnostic performance was assessed by independent sample t-test, chi-square test, logistic regression analysis, receiver operating characteristic curve (ROC), and DeLong test. Results: NPL has significantly lower T2, PD, and ADC values compared to NPC (all P < .05), whereas no significant difference was found in T1 value between these two entities (P > .05). The morphological features of tumour type, skull-base involvement, Waldeyer ring involvement, and lymph nodes involvement region were significantly different between NPL and NPC (all P < .05). The syMRI (T2 + PD) model has better diagnostic efficacy, with AUC, sensitivity, specificity, and accuracy of 0.875, 77.27%, 89.36%, and 85.51%. Compared with syMRI model, syMRI + Morph (PD + Waldeyer ring involvement + lymph nodes involvement region), syMRI + DWI (T2 + PD + ADC), and syMRI + DWI + Morph (PD + ADC + skull-base involvement + Waldeyer ring involvement) models can further improve the diagnostic efficiency (all P < .05). Furthermore, syMRI + DWI + Morph model has excellent diagnostic performance, with AUC, sensitivity, specificity, and accuracy of 0.986, 95.47%, 97.87%, and 97.10%, respectively. Conclusion: syMRI and DWI quantitative parameters were helpful in discriminating NPL from NPC. syMRI + DWI + Morph model has the excellent diagnostic efficiency in differentiating these two entities. Advances in Knowledge: syMRI + DWI + morphological feature method can differentiate NPL from NPC with excellent diagnostic performance. (© The Author(s) 2024. Published by Oxford University Press on behalf of the British Institute of Radiology. All rights reserved. For permissions, please email: journals.permissions@oup.com.) |
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| معلومات مُعتمدة: | Q202240 Wuxi Health Committee; Y20212020 Department of Science and Technology of Wuxi Government; BK20221203 Natural Science Foundation of Jiangsu Province; 2023M731345 China Postdoctoral Science Foundation; BJ2023043 Top Talent Support Program for Young and Middle-Aged People of Wuxi Health Committee |
| فهرسة مساهمة: | Keywords: diffusion-weighted imaging; lymphoma; nasopharyngeal carcinoma; synthetic magnetic resonance imaging |
| تواريخ الأحداث: | Date Created: 20240511 Date Completed: 20240619 Latest Revision: 20240621 |
| رمز التحديث: | 20240621 |
| مُعرف محوري في PubMed: | PMC11186575 |
| DOI: | 10.1093/bjr/tqae095 |
| PMID: | 38733577 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1748-880X |
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| DOI: | 10.1093/bjr/tqae095 |