دورية أكاديمية
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Modifying the Backbone Chemistry of PEG-Based Bottlebrush Block Copolymers for the Formation of Long-Circulating Nanoparticles.

التفاصيل البيبلوغرافية
العنوان: Modifying the Backbone Chemistry of PEG-Based Bottlebrush Block Copolymers for the Formation of Long-Circulating Nanoparticles.
المؤلفون: Grundler J; Department of Chemistry and Department of Biomedical Engineering, Yale University, New Haven, CT, 06511, USA., Whang CH; Department of Biomedical Engineering, Yale University, New Haven, CT, 06511, USA., Shin K; Department of Polymer Science & Engineering and Environmental Engineering, Inha University, Incheon, 22212, South Korea., Savan NA; Department of Biomedical Engineering, Yale University, New Haven, CT, 06511, USA.; Medical Scientist Training Program, Yale School of Medicine, New Haven, CT, 06510, USA., Zhong M; Department of Chemical Engineering and Department of Chemistry, Yale University, New Haven, CT, 06511, USA., Saltzman WM; Department of Biomedical Engineering, Yale University, New Haven, CT, 06511, USA.; Department of Cellular & Molecular Physiology and Department of Dermatology, Yale School of Medicine, New Haven, CT, 06510, USA.
المصدر: Advanced healthcare materials [Adv Healthc Mater] 2024 Sep; Vol. 13 (22), pp. e2304040. Date of Electronic Publication: 2024 May 22.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101581613 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2192-2659 (Electronic) Linking ISSN: 21922640 NLM ISO Abbreviation: Adv Healthc Mater Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Weinheim : Wiley-VCH, 2012-
مواضيع طبية MeSH: Polyethylene Glycols*/chemistry , Nanoparticles*/chemistry, Animals ; Mice ; Humans ; Polyesters/chemistry ; Cell Line, Tumor ; Micelles
مستخلص: Nanoparticle physicochemical properties have received great attention in optimizing the performance of nanoparticles for biomedical applications. For example, surface functionalization with small molecules or linear hydrophilic polymers is commonly used to tune the interaction of nanoparticles with proteins and cells. However, it is challenging to control the location of functional groups within the shell for conventional nanoparticles. Nanoparticle surfaces composed of shape-persistent bottlebrush polymers allow hierarchical control over the nanoparticle shell but the effect of the bottlebrush backbone on biological interactions is still unknown. The synthesis is reported of novel heterobifunctional poly(ethylene glycol) (PEG)-norbornene macromonomers modified with various small molecules to form bottlebrush polymers with different backbone chemistries. It is demonstrated that micellar nanoparticles composed of poly(lactic acid) (PLA)-PEG bottlebrush block copolymer (BBCP) with neutral and cationic backbone modifications exhibit significantly reduced cellular uptake compared to conventional unmodified BBCPs. Furthermore, the nanoparticles display long blood circulation half-lives of ≈22 hours and enhanced tumor accumulation in mice. Overall, this work sheds light on the importance of the bottlebrush polymer backbone and provides a strategy to improve the performance of nanoparticles in biomedical applications.
(© 2024 Wiley‐VCH GmbH.)
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معلومات مُعتمدة: R01 HL139756 United States HL NHLBI NIH HHS; U01 AI145965 United States AI NIAID NIH HHS; R01 HL139756 United States NH NIH HHS; U01 AI145965 United States NH NIH HHS; U01 AI145965 United States NH NIH HHS; R01 HL139756 United States NH NIH HHS
فهرسة مساهمة: Keywords: nanoparticle; pharmacokinetics; poly(ethylene glycol); polymer; ring‐opening metathesis polymerization
المشرفين على المادة: 3WJQ0SDW1A (Polyethylene Glycols)
0 (Polyesters)
0 (Micelles)
تواريخ الأحداث: Date Created: 20240511 Date Completed: 20240902 Latest Revision: 20240905
رمز التحديث: 20240905
مُعرف محوري في PubMed: PMC11368614
DOI: 10.1002/adhm.202304040
PMID: 38734871
قاعدة البيانات: MEDLINE
الوصف
تدمد:2192-2659
DOI:10.1002/adhm.202304040